{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:21:38Z","timestamp":1787235698349,"version":"build-2736575974"},"reference-count":32,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiol Bras"],"abstract":"<jats:p>Abstract The middle cerebellar peduncle (MCP) is the largest afferent system of the cerebellum and consists of fibres from the cortico-ponto-cerebellar tract. Specifically, several relevant diseases can present with hyperintensity in the MCP on T2-weighted\/fluid-attenuated inversion recovery (T2\/FLAIR) magnetic resonance imaging sequences, including multiple sclerosis; acute disseminated encephalomyelitis; neuromyelitis optica spectrum disorder; progressive multifocal leucoencephalopathy; hepatic encephalopathy; osmotic demyelination syndrome; multiple system atrophy; fragile X-associated tremor\/ataxia syndrome; megalencephalic leucoencephalopathy with subcortical cysts; spinocerebellar ataxias; hemi-pontine infarct with trans-axonal degeneration; and diffuse midline glioma with the histone H3K27M mutation. The aim of this pictorial review is to discuss the imaging findings that are relevant for the differential diagnosis of diseases presenting with MCP hyperintensity on T2\/FLAIR sequences. Such knowledge is of utmost importance for the practicing radiologist.<\/jats:p>","DOI":"10.1590\/0100-3984.2024.0001","type":"journal-article","created":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T05:42:18Z","timestamp":1738302138000},"source":"Crossref","is-referenced-by-count":6,"title":["Hyperintense lesions of the middle cerebellar peduncle and beyond: a pictorial essay"],"prefix":"10.1590","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6347-9413","authenticated-orcid":false,"given":"Jo\u00e3o Vitor Gerdulli","family":"Tamanini","sequence":"first","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo,  Brazil; Universidade Estadual de Campinas,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9598-3665","authenticated-orcid":false,"given":"Guilherme Antonio Silva","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo,  Brazil; Universidade Estadual de Campinas,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0799-9035","authenticated-orcid":false,"given":"Adriana Tami","family":"Kimura","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2661-4791","authenticated-orcid":false,"given":"Luiz Fernando","family":"Borella","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0324-8568","authenticated-orcid":false,"given":"Tom\u00e1s de Andrade","family":"Freddi","sequence":"additional","affiliation":[{"name":"Hospital do Cora\u00e7\u00e3o,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2256-4379","authenticated-orcid":false,"given":"Fabiano","family":"Reis","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2024]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/ene.13819","article-title":"Multiple sclerosis - a review","volume":"26","author":"Dobson R","year":"2019","journal-title":"Eur J Neurol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S1474-4422(17)30470-2","article-title":"Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria","volume":"17","author":"Thompson AJ","year":"2018","journal-title":"Lancet Neurol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1053\/j.sult.2023.03.017","article-title":"The role of MRI in differentiating demyelinating and inflammatory (not infectious) myelopathies","volume":"44","author":"Tamanini JVG","year":"2023","journal-title":"Semin Ultrasound CT MR"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1056\/NEJMra1904655","article-title":"Neuromyelitis optica spectrum disorder","volume":"387","author":"Wingerchuk DM","year":"2022","journal-title":"N Engl J Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1590\/0100-3984.2021.0111","article-title":"Common and uncommon neuroimaging manifestations of ataxia: an illustrated guide for the trainee radiologist. 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