{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T21:13:36Z","timestamp":1778966016778,"version":"3.51.4"},"reference-count":29,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiol Bras"],"abstract":"<jats:p>Abstract  Objective: To investigate clinical, pathology, and imaging findings associated with inguinal lymph node (LN) metastases in patients with prostate cancer (PCa).  Materials and Methods: This was a retrospective single-center study of patients with PCa who underwent imaging and inguinal LN biopsy between 2000 and 2023. We assessed the following aspects on multimodality imaging: inguinal LN morphology; extrainguinal lymphadenopathy; the extent of primary and recurrent tumors; and non-nodal metastases. Imaging, clinical, and pathology features were compared between patients with and without metastatic inguinal LNs.  Results: We evaluated 79 patients, of whom 38 (48.1%) had pathology-proven inguinal LN metastasis. Certain imaging aspects\u2014 short-axis diameter, prostate-specific membrane antigen uptake on positron-emission tomography, membranous urethra involvement by the tumor, extra-inguinal lymphadenopathy, and distant metastases\u2014were associated with pathology-proven inguinal LN metastases (p &lt; 0.01 for all). Associations with long-axis diameter, fatty hilum, laterality, and uptake of other tracers on positronemission tomography were not significant (p = 0.09\u20131.00). The patients with metastatic inguinal LNs had higher prostate-specific antigen levels and more commonly had castration-resistant PCa (p &lt; 0.01), whereas age, histological grade, and treatment type were not significant factors (p = 0.07\u20130.37). None of the patients had inguinal LN metastasis in the absence of locally advanced disease with membranous urethra involvement or distant metastasis.  Conclusion: Several imaging, clinical, and pathology features are associated with inguinal LN metastases in patients with PCa. Isolated metastasis to inguinal LNs is extremely rare and unlikely to occur in the absence of high-risk imaging, clinical, or pathology features.<\/jats:p>","DOI":"10.1590\/0100-3984.2024.0013","type":"journal-article","created":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T03:59:12Z","timestamp":1720497552000},"source":"Crossref","is-referenced-by-count":4,"title":["Inguinal lymph node metastases from prostate cancer: clinical, pathology, and multimodality imaging considerations"],"prefix":"10.1590","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8459-8369","authenticated-orcid":false,"given":"Sungmin","family":"Woo","sequence":"first","affiliation":[{"name":"NYU Langone Health,  USA; Memorial Sloan Kettering Cancer Center,  USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8372-6496","authenticated-orcid":false,"given":"Anton S.","family":"Becker","sequence":"additional","affiliation":[{"name":"NYU Langone Health,  USA; Memorial Sloan Kettering Cancer Center,  USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8459-7363","authenticated-orcid":false,"given":"Soleen","family":"Ghafoor","sequence":"additional","affiliation":[{"name":"University Hospital Zurich,  Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3986-1778","authenticated-orcid":false,"given":"Felipe de Galiza","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Hospital S\u00edrio-Liban\u00eas,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5285-0352","authenticated-orcid":false,"given":"Yuki","family":"Arita","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center,  USA; Keio University School of Medicine,  Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1169-133X","authenticated-orcid":false,"given":"Hebert A.","family":"Vargas","sequence":"additional","affiliation":[{"name":"NYU Langone Health,  USA; Memorial Sloan Kettering Cancer Center,  USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2024]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1002\/pros.22742","article-title":"Distribution of metastatic sites in patients with prostate cancer: a population-based analysis","volume":"74","author":"Gandaglia G","year":"2014","journal-title":"Prostate"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.clgc.2013.04.031","article-title":"A better understanding of lymphatic drainage of the prostate with modern imaging and surgical techniques","volume":"11","author":"Swanson GP","year":"2013","journal-title":"Clin Genitourin Cancer"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.clon.2005.09.006","article-title":"Distribution of lymph nodes in men with prostatic adenocarcinoma and lymphadenopathy at presentation: a retrospective radiological review and implications for prostate and pelvis radiotherapy","volume":"18","author":"Jackson ASN","year":"2006","journal-title":"Clin Oncol (R Coll Radiol)"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.euo.2020.04.004","article-title":"PSMA-PET\/CT-based lymph node atlas for prostate cancer patients recurring after primary treatment: clinical implications for salvage radiation therapy","volume":"4","author":"Schiller K","year":"2021","journal-title":"Eur Urol Oncol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"96","DOI":"10.5173\/ceju.2012.02.art11","article-title":"A case of metastatic prostate adenocarcinoma to an inguinal lymph node","volume":"65","author":"Komeya M","year":"2012","journal-title":"Cent European J Urol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"56","DOI":"10.4103\/0970-1591.109986","article-title":"Penile nodule with inguinal lymphadenopathy: prostatic adenocarcinoma masquerading as penile cancer","volume":"29","author":"Ghosh B","year":"2013","journal-title":"Indian J Urol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"bcr2015210825","DOI":"10.1136\/bcr-2015-210825","article-title":"Prostatic adenocarcinoma presenting as isolated inguinal lymphadenopathy","volume":"2015","author":"Doreswamy K","year":"2015","journal-title":"BMJ Case Rep"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"e1185","DOI":"10.1016\/j.clgc.2019.08.003","article-title":"Metastatic prostate cancer presenting with bilateral inguinal lymphadenopathy","volume":"17","author":"Elsaqa M","year":"2019","journal-title":"Clin Genitourin 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pathology","first-page":"534","volume-title":"Urethra","author":"Reuter VE","year":"2020","edition":"4th"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"6116","DOI":"10.1007\/s00330-020-07572-4","article-title":"Introducing the Node Reporting and Data System 1.0 (Node-RADS): a concept for standardized assessment of lymph nodes in cancer","volume":"31","author":"Elsholtz FHJ","year":"2021","journal-title":"Eur Radiol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.cpet.2016.11.005","article-title":"Imaging of prostate cancer using fluciclovine","volume":"12","author":"Savir-Baruch B","year":"2017","journal-title":"PET Clin"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"469","DOI":"10.2967\/jnumed.117.198119","article-title":"Prostate cancer molecular imaging standardized evaluation (PROMISE): proposed miTNM classification for the interpretation of PSMA-ligand PET\/CT","volume":"59","author":"Eiber 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meta-analysis","volume":"63","author":"H\u00f6vels AM","year":"2008","journal-title":"Clin Radiol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1097\/JU.0000000000001698","article-title":"A phase 2\/3 prospective multicenter study of the diagnostic accuracy of prostate specific membrane antigen PET\/CT with 18F-DCFPyL in prostate cancer patients (OSPREY)","volume":"206","author":"Pienta KJ","year":"2021","journal-title":"J Urol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"e5","DOI":"10.1016\/j.urology.2016.11.040","article-title":"Prostate-specific membrane antigen-targeted ligand positron emission tomography\/computed tomography and immunohistochemical findings in a patient with synchronous metastatic penile and prostate cancer","volume":"101","author":"Froehner M","year":"2017","journal-title":"Urology"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"e96","DOI":"10.1097\/RLU.0000000000002738","article-title":"18F-DCFPyL uptake in an incidentally detected follicular lymphoma by PET\/CT performed for biochemically recurrent prostate cancer","volume":"45","author":"Meijer D","year":"2020","journal-title":"Clin Nucl Med"},{"key":"ref25","series-title":"Anatomie g\u00e9n\u00e9rale: origines des formes et des structures anatomiques","author":"Rouvi\u00e8re H.","year":"1939"},{"issue":"10","key":"ref26","first-page":"e200","article-title":"Inguinal lymph node metastases are recognized with high frequency in rectal adenocarcinoma invading the dentate line. The histological features at the invasive front may predict inguinal lymph node metastasis","volume":"12","author":"Hamano T","year":"2010","journal-title":"Colorectal Dis"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s13000-017-0599-2","article-title":"Clinicopathological study of 9 cases of prostate cancer involving the rectal wall","volume":"12","author":"Tang T","year":"2017","journal-title":"Diagn Pathol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1097\/JU.0000000000002439","article-title":"Prevalence of highrisk prostate cancer metastasis to Cloquet\u2019s ilioinguinal lymph node","volume":"207","author":"Plata Bello A","year":"2022","journal-title":"J Urol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"136","DOI":"10.23736\/S0393-2249.19.03342-3","article-title":"Extended pelvic lymphadenectomy for prostate cancer: should the Cloquet\u2019s nodes dissection be considered only an option?","volume":"71","author":"Cacciamani GE","year":"2019","journal-title":"Minerva Urol Nefrol"}],"container-title":["Radiologia Brasileira"],"original-title":["Met\u00e1stases de linfonodos inguinais de c\u00e2ncer de pr\u00f3stata: considera\u00e7\u00f5es cl\u00ednicas, patol\u00f3gicas e de imagem multimodalidade"],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S0100-39842024000100210&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T03:59:29Z","timestamp":1720497569000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0100-39842024000100210&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":29,"alternative-id":["S0100-39842024000100210"],"URL":"https:\/\/doi.org\/10.1590\/0100-3984.2024.0013","relation":{},"ISSN":["1678-7099"],"issn-type":[{"value":"1678-7099","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]},"article-number":"e20240013"}}