{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:01:03Z","timestamp":1753887663782,"version":"3.41.2"},"reference-count":31,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiol Bras"],"abstract":"<jats:p>Abstract  Objective: To analyze longitudinal changes between two brain magnetic resonance imaging (MRI) exams performed one year apart in symptomatic infants with congenital Zika syndrome (CZS) and normocephalic infants exposed to the Zika virus (ZIKV) prenatally.  Materials and Methods: This was a prospective observational study. Infants born to women who tested positive for ZIKV on reverse transcription-quantitative polymerase chain reaction during pregnancy were classified into two groups: symptomatic infants with CZS and asymptomatic infants. All of the infants underwent brain MRI at presentation and after one year of follow-up. All MRI scans were evaluated independently by a pediatric radiologist and a pediatric neuroradiologist, and the infants underwent clinical monitoring by a pediatric neurologist.  Results: The sample included 36 infants exposed to ZIKV perinatally. Therefore, a total of 72 MRI scans were evaluated. Among the 36 infants included a diagnosis of CZS was made in 25 (69.4%), of whom 18 presented with a combination of classic findings (including reduced brain volume, subcortical calcifications, brainstem hypoplasia, malformations of the corpus callosum, malformations of cortical development, and ventriculomegaly), as well as atypical findings such as hyperintense foci in the white matter on T2-weighted sequences. Of those same 25 infants, seven presented with mild lesions. Of the 11 normocephalic patients, five (13.9%) had atypical findings such as hyperintense foci in the white matter on T2-weighted sequences and no other manifestations of CZS, although there was mild neurological involvement. Six (16.6%) of the 36 patients had completely normal MRI scans with no neurological changes. No disease progression was observed during follow-up.  Conclusion: In infants exposed to ZIKV perinatally, the frequency of classic and atypical findings on brain MRI seems to be associated with the neurological status. Brain MRI is an important diagnostic tool in the evaluation and monitoring of patients with congenital infection, because intracranial changes other than microcephaly can occur.<\/jats:p>","DOI":"10.1590\/0100-3984.2024.0014","type":"journal-article","created":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T12:19:23Z","timestamp":1732537163000},"source":"Crossref","is-referenced-by-count":0,"title":["Brain MRI in infants exposed to the Zika virus, with one-year follow-up: expanding the phenotype"],"prefix":"10.1590","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0032-1328","authenticated-orcid":false,"given":"Teresa Cristina de Castro Ramos Sarmet dos","family":"Santos","sequence":"first","affiliation":[{"name":"Universidade Federal Fluminense,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9455-1350","authenticated-orcid":false,"given":"Mai-Lan","family":"Ho","sequence":"additional","affiliation":[{"name":"University of Missouri,  USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2341-1422","authenticated-orcid":false,"given":"Maria de Fatima Vasco","family":"Arag\u00e3o","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pernambuco,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6416-7278","authenticated-orcid":false,"given":"Renata Artimos de Oliveira","family":"Vianna","sequence":"additional","affiliation":[{"name":"Universidade Federal Fluminense,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6253-265X","authenticated-orcid":false,"given":"Alexandre Ribeiro","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Universidade Federal Fluminense,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8640-3657","authenticated-orcid":false,"given":"Alair Augusto Sarmet Moreira Damas dos","family":"Santos","sequence":"additional","affiliation":[{"name":"Universidade Federal Fluminense,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7638-6814","authenticated-orcid":false,"given":"Claudete Aparecida Ara\u00fajo","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Universidade Federal Fluminense,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2024]]},"reference":[{"series-title":"WHO Director-General summarizes the outcome of the Emergency Committee regarding clusters of microcephaly and Guillain-Barr\u00e9 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MFV","year":"2016","journal-title":"BMJ"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1590\/0100-3984.2017.0098","article-title":"Congenital Zika syndrome and neuroimaging findings: what do we know so far?","volume":"50","author":"Niemeyer B","year":"2017","journal-title":"Radiol Bras"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1590\/0100-3984.2016.0135","article-title":"Computed tomography and magnetic resonance imaging findings in infants with microcephaly potentially related to congenital Zika virus infection","volume":"51","author":"Peixoto Filho AAA","year":"2018","journal-title":"Radiol Bras"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.3174\/ajnr.A5216","article-title":"Nonmicrocephalic infants with congenital Zika syndrome suspected only after neuroimaging evaluation compared with those with microcephalic at birth and posnatally: how large is Zika virus 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fen\u00f3tipo"],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S0100-39842024000100217&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T12:19:32Z","timestamp":1732537172000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0100-39842024000100217&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":31,"alternative-id":["S0100-39842024000100217"],"URL":"https:\/\/doi.org\/10.1590\/0100-3984.2024.0014","relation":{},"ISSN":["1678-7099"],"issn-type":[{"type":"electronic","value":"1678-7099"}],"subject":[],"published":{"date-parts":[[2024]]},"article-number":"e20240014"}}