{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:02:39Z","timestamp":1753887759939,"version":"3.41.2"},"reference-count":37,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiol Bras"],"abstract":"<jats:p>Abstract  Objective: To explore the feasibility of two magnetic resonance imaging (MRI) sequences\u2014high-resolution T2-weighted (HR T2) and Look-Locker T1 (LL T1) relaxometry\u2014for the investigation focal lung lesions (FLLs). As a secondary objective, we analyzed the diagnostic accuracy of these sequences.  Materials and Methods: This was a prospective observational study involving 39 subjects with FLLs scanned in a 1.5-T MRI system with LL T1 relaxometry and HR T2 sequences focused on the FLL region, in addition to a conventional protocol. All images were evaluated by two radiologists, working independently, who were blinded to other findings.  Results: Most of the examinations (31 of the LL T1 relaxometry sequences and 36 of the HR T2 sequences) were of adequate diagnostic quality. Nondiagnostic examinations were considered so mainly because of limited coverage of the sequences. Of the FLLs studied, 19 were malignant, 17 were benign, and three were excluded from the accuracy analysis because there was no definitive diagnosis. Although LL T1 relaxometry could not distinguish between benign and malignant lesions, the signal intensity at its first inversion time (160 ms) differed between the two groups. The HR T2 sequence was considered the best sequence for assessing specific morphological characteristics, especially pseudocavities and pleural tags. We found that MRI showed better accuracy than did computed tomography (86% vs. 74%).  Conclusion: Both MRI sequences are feasible for the evaluation of FLLs. Images at 160 ms of the LL T1 relaxometry sequence helped distinguish between benign and malignant lesions, and the HR T2 sequence was considered the best sequence for evaluating specific morphological characteristics.<\/jats:p>","DOI":"10.1590\/0100-3984.2024.0033","type":"journal-article","created":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T13:17:21Z","timestamp":1728307041000},"source":"Crossref","is-referenced-by-count":0,"title":["Look-Locker T1 relaxometry and high-resolution T2 in the evaluation of lung lesions: a single-center prospective study"],"prefix":"10.1590","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6433-4849","authenticated-orcid":false,"given":"Danilo Tadao","family":"Wada","sequence":"first","affiliation":[{"name":"Faculdade de Medicina de Ribeir\u00e3o Preto da Universidade de S\u00e3o Paulo (FMRP-USP),  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8136-1021","authenticated-orcid":false,"given":"Li Siyuan","family":"Wada","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina de Ribeir\u00e3o Preto da Universidade de S\u00e3o Paulo (FMRP-USP),  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6812-506X","authenticated-orcid":false,"given":"Camila Vilas Boas","family":"Machado","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina de Ribeir\u00e3o Preto da Universidade de S\u00e3o Paulo (FMRP-USP),  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6127-7295","authenticated-orcid":false,"given":"Mateus Repol\u00eas","family":"Louren\u00e7o","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina de Ribeir\u00e3o Preto da Universidade de S\u00e3o Paulo (FMRP-USP),  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0638-2399","authenticated-orcid":false,"given":"Tales Rubens de","family":"Nadai","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina de Ribeir\u00e3o Preto da Universidade de S\u00e3o Paulo (FMRP-USP),  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6356-2516","authenticated-orcid":false,"given":"Federico Enrique Garcia","family":"Cipriano","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina de Ribeir\u00e3o Preto da Universidade de S\u00e3o Paulo (FMRP-USP),  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7687-3161","authenticated-orcid":false,"given":"Alexandre Todorovic","family":"Fabro","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina de Ribeir\u00e3o Preto da Universidade de S\u00e3o Paulo (FMRP-USP),  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7160-4691","authenticated-orcid":false,"given":"Marcel","family":"Koenigkam-Santos","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina de Ribeir\u00e3o Preto da Universidade de S\u00e3o Paulo (FMRP-USP),  Brazil; Faculdade de Medicina de Bauru da Universidade de S\u00e3o Paulo (FMBRU-USP),  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2024]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1148\/radiographics.20.1.g00ja0343","article-title":"Solitary pulmonary nodules: Part I. Morphologic evaluation for differentiation of benign and malignant lesions","volume":"20","author":"Erasmus JJ","year":"2000","journal-title":"Radiographics"},{"key":"ref2","first-page":"427","article-title":"Solitary pulmonary nodules found in a community-wide chest roentgenographc survey; a five-year follow-up study","volume":"79","author":"Holin SM","year":"1959","journal-title":"Am Rev Tuberc"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1590\/0100-3984.2014.0012","article-title":"Solitary pulmonary nodule and 18F-FDG PET\/CT. Part 1: epidemiology, morphological evaluation and cancer probability","volume":"49","author":"Mosmann MP","year":"2016","journal-title":"Radiol Bras"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1513\/AnnalsATS.201907-517RL","article-title":"Prevalence of pulmonary nodules detected by computed tomography in World Trade Center rescue and recovery workers","volume":"17","author":"Sigel KM","year":"2020","journal-title":"Ann Am Thorac Soc"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1056\/NEJMoa1102873","article-title":"Reduced lung-cancer mortality with low-dose computed tomographic screening","volume":"365","author":"Aberle DR","year":"2011","journal-title":"N Engl J Med"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1056\/NEJMoa1209120","article-title":"Results of initial low-dose computed tomographic screening for lung cancer","volume":"368","author":"Church TR","year":"2013","journal-title":"N Engl J Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1056\/NEJMoa1911793","article-title":"Reduced lung-cancer mortality with volume CT screening in a randomized trial","volume":"382","author":"de Koning HJ","year":"2020","journal-title":"N Engl J Med"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1148\/radiology.180.1.2052672","article-title":"CT evaluation for pulmonary metastases in patients with extrathoracic malignancy","volume":"180","author":"Davis SD","year":"1991","journal-title":"Radiology"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0887-2171(95)90027-6","article-title":"CT of pulmonary metastases with pathological correlation","volume":"16","author":"Hirakata K","year":"1995","journal-title":"Semin Ultrasound CT MR"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"180062","DOI":"10.1183\/16000617.0062-2018","article-title":"The use of chest magnetic resonance imaging in interstitial lung disease: a systematic review","volume":"27","author":"Romei C","year":"2018","journal-title":"Eur Respir Rev"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/1759-7714.12203","article-title":"Magnetic resonance imaging for N staging in non-small cell lung cancer: a systematic review and metaanalysis","volume":"6","author":"Zhang Y","year":"2015","journal-title":"Thorac Cancer"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1002\/jmri.26009","article-title":"MRI for solitary pulmonary nodule and mass assessment: current state of the art","volume":"47","author":"Ohno Y","year":"2018","journal-title":"J Magn Reson Imaging"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1148\/radiol.2020201138","article-title":"Expanding applications of pulmonary MRI in the clinical evaluation of lung disorders: Fleischner Society position paper","volume":"297","author":"Hatabu H","year":"2020","journal-title":"Radiology"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/1532-429X-12-71","article-title":"Cardiovascular magnetic resonance physics for clinicians: part I","volume":"12","author":"Ridgway JP","year":"2010","journal-title":"J Cardiovasc Magn Reson"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/1532-429X-14-66","article-title":"Cardiovascular magnetic resonance physics for clinicians: part II","volume":"14","author":"Biglands JD","year":"2012","journal-title":"J Cardiovasc Magn Reson"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1148\/rg.263055047","article-title":"Delayed enhancement MR imaging: utility in myocardial assessment","volume":"26","author":"Vogel-Claussen J","year":"2006","journal-title":"Radiographics"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1002\/jmri.22753","article-title":"Myocardial T1 mapping with MRI: comparison of look-locker and MOLLI sequences","volume":"34","author":"Nacif MS","year":"2011","journal-title":"J Magn Reson Imaging"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.eururo.2019.10.024","article-title":"Multiparametric magnetic resonance imaging for the detection of clinically significant prostate cancer: what urologists need to know. Part 2: interpretation","volume":"77","author":"Isra\u00ebl B","year":"2020","journal-title":"Eur Urol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.eururo.2019.02.033","article-title":"Prostate Imaging Reporting and Data System version 2.1: 2019 update of Prostate Imaging Reporting and Data System version 2","volume":"76","author":"Turkbey B","year":"2019","journal-title":"Eur Urol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1148\/rg.2019180114","article-title":"MRI of rectal cancer: tumor staging, imaging techniques, and management","volume":"39","author":"Horvat N","year":"2019","journal-title":"Radiographics"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1148\/radiol.13121361","article-title":"The use of MR imaging in treatment planning for patients with rectal carcinoma: have you checked the \u201cDISTANCE\u201d?","volume":"268","author":"Nougaret S","year":"2013","journal-title":"Radiology"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1148\/radiol.2462070712","article-title":"Fleischner Society: glossary of terms for thoracic imaging","volume":"246","author":"Hansell DM","year":"2008","journal-title":"Radiology"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1148\/radiol.2017161659","article-title":"Guidelines for management of incidental pulmonary nodules detected on CT images: from the Fleischner Society 2017","volume":"284","author":"MacMahon H","year":"2017","journal-title":"Radiology"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1148\/radiol.2017162894","article-title":"Recommendations for measuring pulmonary nodules","volume":"285","author":"Bankier A","year":"2017","journal-title":"Radiology"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1002\/jmri.20969","article-title":"Measurement of signal-to-noise ratios in MR images: influence of multichannel coils, parallel imaging, and reconstruction filters","volume":"26","author":"Dietrich O","year":"2007","journal-title":"J Magn Reson Imaging"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jcmg.2015.11.005","article-title":"T1 mapping: basic technique and clinical applications","volume":"9","author":"Taylor AJ","year":"2016","journal-title":"JACC Cardiovasc Imaging"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/jmri.26288","article-title":"Noncontrast MR angiography: an update","volume":"49","author":"Edelman RR","year":"2019","journal-title":"J Magn Reson Imaging"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"24","DOI":"10.2214\/AJR.12.9543","article-title":"Perfusion MRI: the five most frequently asked technical questions","volume":"200","author":"Essig M","year":"2013","journal-title":"AJR Am J Roentgenol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"S52","DOI":"10.1007\/s00259-010-1456-7","article-title":"Magnetic resonance perfusion imaging without contrast media","volume":"37","author":"Martirosian P","year":"2010","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"282","DOI":"10.5527\/wjn.v3.i4.282","article-title":"Usefulness of hounsfield unit and density in the assessment and treatment of urinary stones","volume":"3","author":"G\u00fcc\u00fck A","year":"2014","journal-title":"World J Nephrol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1002\/mrm.26490","article-title":"Pulmonary relaxometry with inversion recovery ultra-fast steady-state free precession at 1.5T","volume":"77","author":"Bauman G","year":"2017","journal-title":"Magn Reson Med"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1002\/mrm.26739","article-title":"Dynamic and steady-state oxygen-dependent lung relaxometry using inversion recovery ultra-fast steady-state free precession imaging at 1.5 T","volume":"79","author":"Bauman G","year":"2018","journal-title":"Magn Reson Med"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1148\/radiology.187.1.8451432","article-title":"Chest wall invasion by bronchogenic carcinoma: evaluation with MR imaging","volume":"187","author":"Padovani B","year":"1993","journal-title":"Radiology"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"e103","DOI":"10.1097\/MAO.0000000000002436","article-title":"Usefulness of high resolution T2-weighted images in the evaluation and surveillance of vestibular schwannomas? Is gadolinium needed?","volume":"41","author":"Pizzini FB","year":"2020","journal-title":"Otol Neurotol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1007\/s00330-018-5515-y","article-title":"Endometrial cancer MRI staging: updated guidelines of the European Society of Urogenital Radiology","volume":"29","author":"Nougaret S","year":"2019","journal-title":"Eur Radiol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.eururo.2018.04.029","article-title":"Multiparametric magnetic resonance imaging for bladder cancer: development of VI-RADS (Vesical Imaging-Reporting And Data System)","volume":"74","author":"Panebianco V","year":"2018","journal-title":"Eur Urol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"W37","DOI":"10.2214\/AJR.05.1795","article-title":"High-resolution MRI in evaluation of the surgical anatomy of the esophagus and posterior mediastinum","volume":"188","author":"Riddell AM","year":"2007","journal-title":"AJR Am J Roentgenol"}],"container-title":["Radiologia Brasileira"],"original-title":["Relaxometria T1 baseada em Look-Locker e T2 de alta resolu\u00e7\u00e3o na avalia\u00e7\u00e3o de les\u00f5es pulmonares: um estudo prospectivo unic\u00eantrico"],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S0100-39842024000100216&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T13:17:31Z","timestamp":1728307051000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0100-39842024000100216&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":37,"alternative-id":["S0100-39842024000100216"],"URL":"https:\/\/doi.org\/10.1590\/0100-3984.2024.0033","relation":{},"ISSN":["1678-7099"],"issn-type":[{"type":"electronic","value":"1678-7099"}],"subject":[],"published":{"date-parts":[[2024]]},"article-number":"e20240033"}}