{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T19:26:25Z","timestamp":1793042785057,"version":"4.5.0"},"reference-count":40,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiol Bras"],"abstract":"<jats:p>Abstract Systemic sclerosis (SSc) is a multifaceted autoimmune condition that leads to fibrosis in the skin and various internal organs, including the lungs. One of its most serious complications is interstitial lung disease (ILD), which has a profound impact on the prognosis and on patient quality of life. High-resolution computed tomography (HRCT) plays a critical role by offering detailed structural information, whereas positron-emission tomography\/CT (PET\/CT) provides a deeper understanding of disease activity by combining metabolic and anatomical data. Radiomics expands on those modalities, extracting subtle imaging features undetectable by visual analysis, thereby enabling superior diagnostic accuracy, staging, and prognostic accuracy. This review explores the current applications of radiomics in SSc-ILD, highlighting breakthroughs such as the integration of artificial intelligence for early ILD prediction and risk stratification. Studies have demonstrated that radiomics is efficacious in overcoming traditional diagnostic limitations, enhancing precision in identifying the patterns of usual interstitial pneumonia and monitoring disease progression. When applied to PET\/CT, especially that using advanced tracers, radiomics can complement HRCT by identifying metabolic biomarkers of ILD activity, thus supporting personalized treatment strategies. Although radiomics holds significant transformative potential, its routine use in clinical practice still faces several obstacles, such as the need for standardization, validation, and consistency across institutions. Future efforts will be focused on combining radiomics with genetic and molecular data, developing artificial intelligence-driven longitudinal models, and adopting multimodal approaches to improve the management of SSc-ILD. These advances promise to drive a shift toward precision medicine, ultimately improving outcomes for patients with this complex disease.<\/jats:p>","DOI":"10.1590\/0100-3984.2025.0021","type":"journal-article","created":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T15:03:04Z","timestamp":1761318184000},"source":"Crossref","is-referenced-by-count":4,"title":["Radiomics in PET\/CT and HRCT for systemic sclerosis-associated interstitial lung disease: breakthroughs and future directions"],"prefix":"10.1590","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3072-2763","authenticated-orcid":false,"given":"Andr\u00e9a de Lima","family":"Bastos","sequence":"first","affiliation":[{"name":"Faculdade de Medicina da Universidade Federal de Minas Gerais (UFMG),  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5818-0954","authenticated-orcid":false,"given":"Marcelo","family":"Mamede","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina da Universidade Federal de Minas Gerais (UFMG),  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2025]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1055\/s-0034-1371541","article-title":"Interstitial lung disease in systemic sclerosis","volume":"35","author":"Wells AU","year":"2014","journal-title":"Semin Respir Crit Care Med."},{"key":"ref2","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1007\/s11926-010-0095-0","article-title":"Imaging lung disease in systemic sclerosis","volume":"12","author":"Strollo D","year":"2010","journal-title":"Curr Rheumatol Rep."},{"key":"ref3","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1164\/rccm.201308-1483ST","article-title":"An official American Thoracic Society\/European Respiratory Society statement: Update of the international multidisciplinary classification of the idiopathic interstitial pneumonias","volume":"188","author":"Travis WD","year":"2013","journal-title":"Am J Respir Crit Care Med."},{"key":"ref4","doi-asserted-by":"crossref","first-page":"e71","DOI":"10.1016\/S2665-9913(19)30144-4","article-title":"The identification and management of interstitial lung disease in systemic sclerosis: evidence-based European consensus statements","volume":"2","author":"Hoffmann-Vold AM","year":"2020","journal-title":"Lancet Rheumatol."},{"key":"ref5","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1590\/0100-3984.2015.0116","article-title":"Tomography patterns of lung disease in systemic sclerosis","volume":"49","author":"Bastos AL","year":"2016","journal-title":"Radiol Bras."},{"key":"ref6","article-title":"PET\/CT and inflammatory mediators in systemic sclerosis-associated interstitial lung disease","volume":"48","author":"Bastos AL","year":"2022","journal-title":"J Bras Pneumol."},{"key":"ref7","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1177\/2397198320985377","article-title":"Interstitial lung disease in systemic sclerosis quantification of disease classification and progression with high-resolution computed tomography: An observational study","volume":"6","author":"Clukers J","year":"2021","journal-title":"J Scleroderma Relat Disord."},{"key":"ref8","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/S2213-2600(15)00096-X","article-title":"CT staging and monitoring of fibrotic interstitial lung diseases in clinical practice and treatment trials: a position paper from the Fleischner Society","volume":"3","author":"Hansell DM","year":"2015","journal-title":"Lancet Resp Med."},{"key":"ref9","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1164\/rccm.201803-0444PP","article-title":"Computed tomographic biomarkers in idiopathic pulmonary fibrosis. 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futuras"],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S0100-39842025000100307&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T15:03:08Z","timestamp":1761318188000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0100-39842025000100307&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":40,"alternative-id":["S0100-39842025000100307"],"URL":"https:\/\/doi.org\/10.1590\/0100-3984.2025.0021","relation":{},"ISSN":["1678-7099"],"issn-type":[{"value":"1678-7099","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]},"article-number":"e20250021"}}