{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T15:11:59Z","timestamp":1761318719743,"version":"build-2065373602"},"reference-count":39,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiol Bras"],"abstract":"<jats:p>Abstract  Objective: To evaluate the association between first-trimester screening for fetal growth restriction (FGR) and the effect of aspirin use as prophylaxis for this condition, as well as its effect on adverse maternal and perinatal outcomes. A secondary objective was to evaluate the association between a high risk of FGR and adverse perinatal outcomes.  Materials and Methods: This was a retrospective cohort study of pregnant women who did or did not undergo first-trimester screening for FGR. Screening for FGR involved the evaluation of maternal characteristics, mean arterial pressure, and the results of uterine artery Doppler. Pregnancies with an estimated risk \u2265 1:155 were categorized as high risk, whereas those with an estimated risk &lt; 1:155 were categorized as low risk.  Results: We evaluated 499 pregnant women who did not undergo first-trimester screening for FGR (unscreened group) and 615 who did (screened group). The risk of gestational hypertension was lower in the screened group, as evidenced by an adjusted odds ratio (aOR) of 0.24 (95% CI: 0.14\u20130.39; p &lt; 0.001), as was the risk of spontaneous preterm birth at &lt; 37 weeks of gestation (aOR: 0.22; 95% CI: 0.10\u20130.45; p &lt; 0.001). The risk of delivery at &lt; 32 weeks was higher in the screened group (aOR: 8.25; 95% CI: 1.05\u201365.71; p &lt; 0.045) as was the risk of delivery at &lt; 37 weeks (aOR: 5.91; 95% CI: 2.62\u201313.31; p &lt; 0.001). Among all of the pregnancies at high risk of FGR (in both groups), there was an increased risk of delivery at &lt; 32 weeks (3.1% vs. 0.2%; OR: 16.20; 95% CI: 2.20\u2013190.90; p = 0.004), and at &lt; 37 weeks (10.7% vs. 1.4%; OR: 8.41; 95% CI: 3.60\u201322.10; p &lt; 0.0001). The use of aspirin was associated with a greater prevalence of gestational hypertension (8.0% vs. 2.1%; OR: 4.1; 95% CI: 1.77\u201310.10; p = 0.0014) and of a birth weight &lt; 2,500 g (14.5% vs. 7.3%; OR: 2.14; 95% CI: 1.25\u20133.71; p = 0.009).  Conclusion: First-trimester screening for FGR seems to be associated with a higher risk of preterm birth (at &lt; 32 and &lt; 37 weeks). Pregnancies that are at high risk of FGR appear to also be at a higher risk of adverse perinatal outcomes. Aspirin use seems to be associated with a greater prevalence of developing gestational hypertension and of a birth weight &lt; 2,500 g.<\/jats:p>","DOI":"10.1590\/0100-3984.2025.0031","type":"journal-article","created":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T15:03:21Z","timestamp":1761318201000},"source":"Crossref","is-referenced-by-count":0,"title":["First-trimester screening for fetal growth restriction and adverse maternal\/perinatal outcomes"],"prefix":"10.1590","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4795-2802","authenticated-orcid":false,"given":"Marilia de Lacerda","family":"Silva","sequence":"first","affiliation":[{"name":"Hospital Universit\u00e1rio Mario Palm\u00e9rio \u2013 Universidade de Uberaba (UNIUBE),  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8692-7154","authenticated-orcid":false,"given":"Barbara Coppola","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Hospital Universit\u00e1rio Mario Palm\u00e9rio \u2013 Universidade de Uberaba (UNIUBE),  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6464-4904","authenticated-orcid":false,"given":"Felipe Augusto Pereira dos","family":"Santos","sequence":"additional","affiliation":[{"name":"Hospital Universit\u00e1rio Mario Palm\u00e9rio \u2013 Universidade de Uberaba (UNIUBE),  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8925-7683","authenticated-orcid":false,"given":"Karine Mendon\u00e7a Davi","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Hospital Universit\u00e1rio Mario Palm\u00e9rio \u2013 Universidade de Uberaba (UNIUBE),  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4634-8972","authenticated-orcid":false,"given":"Luis Ronan Marquez Ferreira de","family":"Sousa","sequence":"additional","affiliation":[{"name":"Universidade Federal do Tri\u00e2ngulo Mineiro (UFTM),  Brazil; Sabin Medicina Diagn\u00f3stica,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4941-623X","authenticated-orcid":false,"given":"Ana Carolina Rabachini","family":"Caetano","sequence":"additional","affiliation":[{"name":"Escola Paulista de Medicina \u2013 Universidade Federal de S\u00e3o Paulo (EPM-Unifesp),  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6145-2532","authenticated-orcid":false,"given":"Edward","family":"Araujo J\u00fanior","sequence":"additional","affiliation":[{"name":"Escola Paulista de Medicina \u2013 Universidade Federal de S\u00e3o Paulo (EPM-Unifesp),  Brazil; Universidade Municipal de S\u00e3o Caetano do Sul (USCS),  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6196-7712","authenticated-orcid":false,"given":"Luciano Marcondes Machado","family":"Nardozza","sequence":"additional","affiliation":[{"name":"Escola Paulista de Medicina \u2013 Universidade Federal de S\u00e3o Paulo (EPM-Unifesp),  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1655-3609","authenticated-orcid":false,"given":"Alberto Borges","family":"Peixoto","sequence":"additional","affiliation":[{"name":"Hospital Universit\u00e1rio Mario Palm\u00e9rio \u2013 Universidade de Uberaba (UNIUBE),  Brazil; Universidade Federal do Tri\u00e2ngulo Mineiro (UFTM),  Brazil; Sabin Medicina Diagn\u00f3stica,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2025]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1159\/000357592","article-title":"Update on the diagnosis and classification of fetal growth restriction and proposal of a stage-based management protocol","volume":"36","author":"Figueras F","year":"2014","journal-title":"Fetal Diagn Ther."},{"key":"ref2","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1111\/j.0001-6349.2004.00602.x","article-title":"Restricted fetal growth in sudden intrauterine unexplained death","volume":"83","author":"Fr\u00f8en JF","year":"2004","journal-title":"Acta Obstet Gynaecol Scand"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"f108","DOI":"10.1136\/bmj.f108","article-title":"Maternal and fetal risk factors for stillbirth: population-based study","volume":"346","author":"Gardosi 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neonates?","volume":"61","author":"Park F","year":"2021","journal-title":"Aust N Z J Obstet Gynaecol."},{"key":"ref38","doi-asserted-by":"crossref","first-page":"5582","DOI":"10.3390\/jcm12175582","article-title":"Screening for preeclampsia and fetal growth restriction in the first trimester in women without chronic hypertension","volume":"12","author":"Tousty P","year":"2023","journal-title":"J Clin Med."},{"year":"2014","series-title":"The investigation and management of the small-for-gestational-age fetus: Green-top Guideline No. 31. 2nd Edition \/ February 2013 \/ minor revisions \u2013 January 2014","key":"ref39"}],"container-title":["Radiologia Brasileira"],"original-title":["Rastreamento de primeiro trimestre para restri\u00e7\u00e3o do crescimento fetal e resultados maternos e perinatais adversos"],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S0100-39842025000100216&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T15:03:26Z","timestamp":1761318206000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0100-39842025000100216&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":39,"alternative-id":["S0100-39842025000100216"],"URL":"https:\/\/doi.org\/10.1590\/0100-3984.2025.0031","relation":{},"ISSN":["1678-7099"],"issn-type":[{"type":"electronic","value":"1678-7099"}],"subject":[],"published":{"date-parts":[[2025]]},"article-number":"e20250031"}}