{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:37:12Z","timestamp":1792089432487,"version":"4.4.0"},"reference-count":65,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiol Bras"],"abstract":"<jats:p>Abstract Pituitary neuroendocrine tumors, previously known as pituitary adenomas, are the most common pituitary gland tumors; when larger than 10 mm in diameter, they are called pituitary macroadenomas. Although most pituitary macroadenomas exhibit characteristic imaging features, some present with uncommon neuroimaging manifestations. Less common imaging manifestations include hemorrhage, areas of necrosis, cystic components, calcifications, bone invasion, and extrasellar location. Knowing how to recognize the atypical neuroimaging patterns of pituitary macroadenomas is also crucial for identifying the potential aggressive behavior of the lesion. In addition to predicting aggressive behavior, recognition of atypical neuroimaging characteristics can help the neurosurgeon determine the most effective surgical approach. The aim of this review was to highlight the less common imaging patterns of pituitary macroadenomas.<\/jats:p>","DOI":"10.1590\/0100-3984.2025.0065","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T15:01:05Z","timestamp":1769180465000},"source":"Crossref","is-referenced-by-count":1,"title":["Pituitary macroadenoma: less common neuroimaging features in a common lesion"],"prefix":"10.1590","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0828-7806","authenticated-orcid":false,"given":"Fernanda Veloso","family":"Pereira","sequence":"first","affiliation":[{"name":"Universidade Estadual de Campinas,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6841-9484","authenticated-orcid":false,"given":"Nat\u00e1lia Yaktine","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica de Campinas,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1151-9652","authenticated-orcid":false,"given":"Davi Ferreira","family":"Soares","sequence":"additional","affiliation":[{"name":"Instituto Tecnol\u00f3gico da Aeron\u00e1utica,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6117-8548","authenticated-orcid":false,"given":"Heraldo Mendes","family":"Garmes","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7434-5701","authenticated-orcid":false,"given":"Denise Engelbrecht","family":"Zantut-Wittmann","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5712-7617","authenticated-orcid":false,"given":"F\u00e1bio","family":"Rog\u00e9rio","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8645-0103","authenticated-orcid":false,"given":"Mateus Dal","family":"Fabbro","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4973-2889","authenticated-orcid":false,"given":"Juliana \u00c1vila","family":"Duarte","sequence":"additional","affiliation":[{"name":"Hospital de Cl\u00ednicas de Porto Alegre,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2256-4379","authenticated-orcid":false,"given":"Fabiano","family":"Reis","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2025]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.4103\/jnsbm.JNSBM_111_17","article-title":"Evaluation of clinical and magnetic resonance imaging profile of pituitary macroadenoma: a prospective study","volume":"9","author":"Gupta K","year":"2018","journal-title":"J Nat Sci Biol Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"928","DOI":"10.3174\/ajnr.A7462","article-title":"The 2021 World Health Organization classification of tumors of the central nervous system: what neuroradiologists need to know","volume":"43","author":"Osborn AG","year":"2022","journal-title":"AJNR Am J Neuroradiol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"4324","DOI":"10.3390\/cancers14174324","article-title":"An overview of pituitary incidentalomas: diagnosis, clinical features, and management","volume":"14","author":"Tahara S","year":"2022","journal-title":"Cancers (Basel)"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.nic.2005.02.007","article-title":"Imaging the sella and parasellar region","volume":"15","author":"Pisaneschi M","year":"2005","journal-title":"Neuroimaging Clin N Am"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1007\/s11604-023-01400-7","article-title":"Imaging of pituitary tumors: an update with the 5th WHO Classifications - part 1. 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