{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T11:39:32Z","timestamp":1792755572049,"version":"4.5.0"},"reference-count":30,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Brazilian Financiadora de Estudos e Projetos\/Minist\u00e9rio da Ci\u00eancia e Tecnologia\/Fundo Setorial de Infraestrutura","award":["01.09.0117.00"],"award-info":[{"award-number":["01.09.0117.00"]}]},{"name":"Brazilian Financiadora de Estudos e Projetos\/Minist\u00e9rio da Ci\u00eancia e Tecnologia\/Fundo Setorial de Infraestrutura","award":["0199\/08"],"award-info":[{"award-number":["0199\/08"]}]},{"name":"Brazilian Financiadora de Estudos e Projetos\/Minist\u00e9rio da Ci\u00eancia e Tecnologia\/Fundo Setorial de Infraestrutura","award":["2012\/50329-6"],"award-info":[{"award-number":["2012\/50329-6"]}]},{"name":"Brazilian Financiadora de Estudos e Projetos\/Minist\u00e9rio da Ci\u00eancia e Tecnologia\/Fundo Setorial de Infraestrutura","award":["2021\/12671-3"],"award-info":[{"award-number":["2021\/12671-3"]}]},{"name":"Brazilian Financiadora de Estudos e Projetos\/Minist\u00e9rio da Ci\u00eancia e Tecnologia\/Fundo Setorial de Infraestrutura","award":["2011.1.9333.1.3"],"award-info":[{"award-number":["2011.1.9333.1.3"]}]},{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","award":["01.09.0117.00"],"award-info":[{"award-number":["01.09.0117.00"]}]},{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","award":["0199\/08"],"award-info":[{"award-number":["0199\/08"]}]},{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","award":["2012\/50329-6"],"award-info":[{"award-number":["2012\/50329-6"]}]},{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","award":["2021\/12671-3"],"award-info":[{"award-number":["2021\/12671-3"]}]},{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","award":["2011.1.9333.1.3"],"award-info":[{"award-number":["2011.1.9333.1.3"]}]},{"name":"University of S\u00e3o Paulo (USP) Provost\u2019s Office for Research","award":["01.09.0117.00"],"award-info":[{"award-number":["01.09.0117.00"]}]},{"name":"University of S\u00e3o Paulo (USP) Provost\u2019s Office for Research","award":["0199\/08"],"award-info":[{"award-number":["0199\/08"]}]},{"name":"University of S\u00e3o Paulo (USP) Provost\u2019s Office for Research","award":["2012\/50329-6"],"award-info":[{"award-number":["2012\/50329-6"]}]},{"name":"University of S\u00e3o Paulo (USP) Provost\u2019s Office for Research","award":["2021\/12671-3"],"award-info":[{"award-number":["2021\/12671-3"]}]},{"name":"University of S\u00e3o Paulo (USP) Provost\u2019s Office for Research","award":["2011.1.9333.1.3"],"award-info":[{"award-number":["2011.1.9333.1.3"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiol Bras"],"abstract":"<jats:p>Abstract  Objective: To describe the contributions of conventional single-photon emission computed tomography (SPECT) and subtraction ictal-interictal SPECT coregistered to magnetic resonance imaging (SISCOM) for the preoperative identification of the epileptogenic zone (EZ) in patients with frontal lobe epilepsy (FLE).  Materials and methods: In this retrospective study, we reviewed medical records of all patients with refractory FLE who underwent frontal lobectomy at our institution between 2015 and 2020, all of whom had undergone at least one ictal SPECT, one interictal SPECT, one high-resolution magnetic resonance imaging examination, SISCOM, and at least one year of follow-up. Fourteen patients met the inclusion criteria.  Results: After a mean follow-up of 32 months (range, 14\u201360 months), surgical outcomes were classified as good in five patients (35.7%) and poor in nine (64.3%). For localizing the EZ, SISCOM achieved the highest sensitivity (80%), negative predictive value (85%), and overall diagnostic accuracy (71%), whereas ictal SPECT had the highest specificity (70%) and interictal SPECT had the lowest performance overall.  Conclusion: In patients with FLE, ictal and interictal SPECT alone do not seem to predict the surgical outcome. However, SISCOM seems to perform better for that purpose.<\/jats:p>","DOI":"10.1590\/0100-3984.2026.0040","type":"journal-article","created":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T10:57:15Z","timestamp":1792753035000},"source":"Crossref","is-referenced-by-count":0,"title":["Contribution of ictal-interictal SPECT and SISCOM to preoperative localization of the epileptogenic zone in frontal lobe epilepsy"],"prefix":"10.1590","volume":"59","author":[{"given":"Lauro","family":"Wichert-Ana","sequence":"first","affiliation":[{"name":"University of S\u00e3o Paulo","place":["Ribeir\u00e3o Preto, SP, Brazil"]},{"name":"University of S\u00e3o Paulo","place":["S\u00e3o Carlos, SP, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo Fernandes","family":"Amaral","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo","place":["Ribeir\u00e3o Preto, SP, Brazil"]},{"name":"University of S\u00e3o Paulo","place":["S\u00e3o Carlos, SP, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1226-3181","authenticated-orcid":false,"given":"Jaqueline Cardena","family":"Fernandes","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo","place":["Ribeir\u00e3o Preto, SP, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4146-1682","authenticated-orcid":false,"given":"Felipe Arriva","family":"Pitella","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo","place":["Ribeir\u00e3o Preto, SP, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8102-9654","authenticated-orcid":false,"given":"Felipe","family":"Mourato","sequence":"additional","affiliation":[{"name":"Hospital das Cl\u00ednicas of the Federal University of Pernambuco","place":["Recife, PE, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mery","family":"Kato","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo","place":["Ribeir\u00e3o Preto, SP, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tonicarlo Rodrigues","family":"Velasco","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo","place":["Ribeir\u00e3o Preto, SP, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederico Nakane","family":"Nakano","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo","place":["Ribeir\u00e3o Preto, SP, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina Teixeira Ramalho Pereira","family":"Dalio","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo","place":["Ribeir\u00e3o Preto, SP, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veriano","family":"Alexandre Jr","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo","place":["Ribeir\u00e3o Preto, SP, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursula","family":"Thom\u00e9","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo","place":["Ribeir\u00e3o Preto, SP, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula Andrada","family":"Hamad","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo","place":["Ribeir\u00e3o Preto, SP, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Carlos","family":"Santos","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo","place":["Ribeir\u00e3o Preto, SP, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Am\u00e9rico Ceiki","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo","place":["S\u00e3o Carlos, SP, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2026]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1159\/000503831","article-title":"The Epidemiology of Epilepsy","volume":"54","author":"Beghi E","year":"2020","journal-title":"Neuroepidemiology"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1056\/NEJMra1004418","article-title":"Drug-resistant epilepsy","volume":"365","author":"Kwan P","year":"2011","journal-title":"N Engl J Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1001\/jama.2014.17426","article-title":"Resective epilepsy surgery for drug-resistant focal epilepsy: a review","volume":"313","author":"Jobst BC","year":"2015","journal-title":"JAMA"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.nec.2020.03.001","article-title":"Networks in Frontal Lobe Epilepsy","volume":"31","author":"Barot N","year":"2020","journal-title":"Neurosurg Clin N Am"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.eplepsyres.2011.10.008","article-title":"Independent predictors and a prognostic model for surgical outcome in refractory frontal lobe epilepsy","volume":"99","author":"Pinheiro-Martins AP","year":"2012","journal-title":"Epilepsy Res"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1093\/brain\/awh449","article-title":"Long-term seizure outcomes following epilepsy surgery: a systematic review and meta-analysis","volume":"128","author":"T\u00e9llez-Zenteno JF","year":"2005","journal-title":"Brain"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.3171\/2012.1.JNS111620","article-title":"Rates and predictors of long-term seizure freedom after frontal lobe epilepsy surgery: a systematic review and meta-analysis","volume":"116","author":"Englot DJ","year":"2012","journal-title":"J Neurosurg"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1002\/epi4.12896","article-title":"Multimodal non-invasive evaluation in MRI-negative epilepsy patients","volume":"9","author":"Wang W","year":"2024","journal-title":"Epilepsia Open"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"17","DOI":"10.2176\/nmc.oa.2018-0286","article-title":"Surgical Technique and Outcome of Extensive Frontal Lobectomy for Treatment of Intracable Non-lesional Frontal Lobe Epilepsy","volume":"60","author":"Hirata S","year":"2020","journal-title":"Neurol Med Chir (Tokyo)"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1552774","DOI":"10.3389\/fneur.2025.1552774","article-title":"Quantitative SISCOM assessment for epileptogenic zone localization: insights from a multicenter study comparing two software platforms in temporal lobe epilepsy","volume":"16","author":"Oliveira Young C","year":"2025","journal-title":"Front Neurol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"467","DOI":"10.3389\/fneur.2020.00467","article-title":"Clinical Usefulness of SISCOM-SPM Compared to Visual Analysis to Locate the Epileptogenic Zone","volume":"11","author":"Oliveira Young C","year":"2020","journal-title":"Front Neurol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1684\/epd.2018.0991","article-title":"Ictal SPECT reveals different epileptogenic zones in frontal lobe epilepsy","volume":"20","author":"Correia P","year":"2018","journal-title":"Epileptic Disord"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.seizure.2019.05.008","article-title":"Utility of MRI, PET, and ictal SPECT in presurgical evaluation of non-lesional pediatric epilepsy","volume":"77","author":"Juh\u00e1sz C","year":"2020","journal-title":"Seizure"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1056\/NEJM199603073341008","article-title":"Surgery for seizures","volume":"334","author":"Engel Jr J","year":"1996","journal-title":"N Engl J Med"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1212\/WNL.43.8.1612","article-title":"Update on surgical treatment of the epilepsies. Summary of the Second International Palm Desert Conference on the Surgical Treatment of the Epilepsies (1992)","volume":"43","author":"Engel Jr J","year":"1993","journal-title":"Neurology"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1111\/epi.13515","article-title":"Diagnostic utility of invasive EEG for epilepsy surgery: Indications, modalities, and techniques","volume":"57","author":"Jayakar P","year":"2016","journal-title":"Epilepsia"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.seizure.2016.06.024","article-title":"The role of SISCOM in preoperative evaluation for patients with epilepsy surgery: A meta-analysis","volume":"41","year":"2016","journal-title":"Seizure"},{"key":"ref18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1006805","article-title":"Controlling seizure propagation in large-scale brain networks","volume":"15","author":"Olmi S","year":"2019","journal-title":"PLOS Computational Biology"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.2147\/NDT.S317915","article-title":"Regional Ictal Hyperperfusion in the Contralateral Occipital Area May Be a Poor Prognostic Marker of Anterior Temporal Lobectomy: A SISCOM Analysis of MTLE Cases","volume":"17","author":"Hwang Y","year":"2021","journal-title":"NDT"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.yebeh.2018.10.033","article-title":"Long-term seizure outcome in frontal lobe epilepsy surgery","volume":"90","author":"Morace R","year":"2019","journal-title":"Epilepsy Behav"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1111\/j.1528-1167.2012.03582.x","article-title":"Outcome of frontal lobe epilepsy surgery","volume":"53","author":"Lazow SP","year":"2012","journal-title":"Epilepsia"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"e32","DOI":"10.1016\/j.wneu.2018.08.192","article-title":"Prognostic Factors and Longitudinal Change in Long-Term Outcome of Frontal Lobe Epilepsy Surgery","volume":"121","author":"Xu C","year":"2019","journal-title":"World Neurosurg"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s13550-024-01095-5","article-title":"Short post-injection seizure duration is associated with reduced power of ictal brain perfusion SPECT to lateralize the seizure onset zone","volume":"14","author":"Karimzadeh A","year":"2024","journal-title":"EJNMMI Res"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.seizure.2019.03.021","article-title":"A study of perfusion changes with Insula Epilepsy using SPECT","volume":"69","year":"2019","journal-title":"Seizure"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"709400","DOI":"10.3389\/fneur.2021.709400","article-title":"Multimodal Image Integration for Epilepsy Presurgical Evaluation: A Clinical Workflow","volume":"12","author":"Jin L","year":"2021","journal-title":"Front Neurol"},{"key":"ref26","first-page":"350","article-title":"Perfusion SPECT, SISCOM and PET (18)F-FDG in the assessment of drug- refractory epilepsy patients candidates for epilepsy surgery","volume":"34","author":"Su\u00e1rez-Pi\u00f1era M","year":"2015","journal-title":"Rev Esp Med Nucl Imagen Mol"},{"key":"ref27","first-page":"1","article-title":"Role of Neuroimaging in the Presurgical Evaluation of Epilepsy","volume":"4","author":"Wehner T","year":"2008","journal-title":"Journal of Clinical Neurology"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/epi4.12373","article-title":"Subtraction Ictal SPECT coregistered to MRI (SISCOM) as a guide in localizing childhood epilepsy","volume":"5","author":"Foiadelli T","year":"2020","journal-title":"Epilepsia Open"},{"key":"ref29","doi-asserted-by":"crossref","DOI":"10.3390\/jpm15120601","article-title":"Multimodal Imaging in Epilepsy Surgery for Personalized Neurosurgical Planning","volume":"15","author":"Fiallo Arroyo J","year":"2025","journal-title":"J Pers Med"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"15158","DOI":"10.1038\/s41598-022-19121-8","article-title":"Multimodal combination of neuroimaging methods for localizing the epileptogenic zone in MR-negative epilepsy","volume":"12","author":"\u0158\u00edha P","year":"2022","journal-title":"Scientific Reports"}],"container-title":["Radiologia Brasileira"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S0100-39842026000100605&tlng=en","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S0100-39842026000100605&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T10:57:20Z","timestamp":1792753040000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0100-39842026000100605&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":30,"alternative-id":["S0100-39842026000100605"],"URL":"https:\/\/doi.org\/10.1590\/0100-3984.2026.0040","relation":{},"ISSN":["1678-7099"],"issn-type":[{"value":"1678-7099","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"article-number":"e20260040"}}