{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T09:34:39Z","timestamp":1777109679010,"version":"3.51.4"},"reference-count":36,"publisher":"FapUNIFESP (SciELO)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Col. Bras. Cir."],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:p>Objective:To analyze the genetic polymorphisms of the cytochrome P450 family and their relationship with squamous cell carcinoma of the oral cavity, pharynx and larynx.Methods: We present a narrative literature review, conducted in Pubmed, Lilacs and Cochrane Databases of articles published in the last five years correlating genetic polymorphisms of the cytochrome P450 family and cancer risk in different populations worldwide.Results: We initially found 65 articles and, after selection criteria, 20 case-control studies with various populations worldwide were eligible. The most studied polymorphisms were those of CYP2E1 and CYP1A1 subfamilies. There is little about the other subfamilies. The association found between polymorphisms and cancer risk amounted to a countless number of variables, amongst them: population, selection methods, racial factors and different modes of exposure to carcinogens, genotyping methods, and nomenclature of the polymorphisms.Conclusion: so far, there is no proven link between genetic polymorphisms of cytochrome P450 family and squamous cell carcinoma of the oral cavity, pharynx and larynx relationship.<\/jats:p>","DOI":"10.1590\/0100-69912014005012","type":"journal-article","created":{"date-parts":[[2014,12,3]],"date-time":"2014-12-03T19:42:21Z","timestamp":1417635741000},"page":"366-372","source":"Crossref","is-referenced-by-count":2,"title":["Genetic polymorphisms in the Cytochrome P450 family and squamous cell carcinoma of the oral cavity, pharynx and larynx"],"prefix":"10.1590","volume":"41","author":[{"given":"Celso Muller","family":"Bandeira","sequence":"first","affiliation":[{"name":"Faculty of Medical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana \u00c1vila de","family":"Almeida","sequence":"additional","affiliation":[{"name":"Faculty of Medical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio Jos\u00e9","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Faculty of Medical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","series-title":"Cancer Fact Sheet No. 297","year":"2014"},{"key":"ref2","series-title":"GLOBOCAN 2008. Cancer Incidence, Mortality and Prevalence Worldwide in 2008","year":"2012"},{"issue":"4","key":"ref3","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/j.0022-0337.2001.65.4.tb03403.x","article-title":"Tobacco use and oral cancer: a global perspective","volume":"65","author":"Johnson N","year":"2001","journal-title":"J Dent Educ."},{"issue":"8","key":"ref4","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/S1368-8375(02)00066-0","article-title":"The epidemiology of oral and pharynx cancer in Brazil","volume":"38","author":"W\u00fcnsch-Filho V","year":"2002","journal-title":"Oral Oncol."},{"issue":"3","key":"ref5","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1097\/CCO.0b013e32832a68ca","article-title":"Recent changes in the epidemiology of head and neck cancer","volume":"21","author":"Curado MP","year":"2009","journal-title":"Curr Opin Oncol."},{"key":"ref6","series-title":"Tipos de C\u00e2ncer: Laringe [Internet]","year":"2012"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/ijc.23033","article-title":"Tobacco smoking and cancer: a meta-analysis","volume":"122","author":"Gandini S","year":"2008","journal-title":"Int J Cancer."},{"key":"ref8","series-title":"Estimativa 2014. Incid\u00eancia de c\u00e2ncer no Brasil [Internet]","year":"2014"},{"key":"ref9","series-title":"WHO report on the global tobacco epidemic, 2011: Warning about the dangers of tobacco","year":"2011"},{"issue":"8","key":"ref10","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1158\/1055-9965.EPI-08-0047","article-title":"Involuntary smoking and head and neck cancer risk: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium","volume":"17","author":"Lee YC","year":"2008","journal-title":"Cancer Epidemiol Biomarkers Prev."},{"issue":"3","key":"ref11","first-page":"225","article-title":"Alcohol drinking in never users of tobacco, cigarette smoking in never drinkers, and the risk of head and neck cancer: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium","volume":"100","author":"Hashibe M","year":"2008","journal-title":"J Natl Cancer Inst. 2007;99(10):777-89. Erratum in: J Natl Cancer Inst."},{"issue":"6","key":"ref12","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1002\/ijc.2910430607","article-title":"Risk factors for oral cancer in Brazil: a case-control study","volume":"43","author":"Franco EL","year":"1989","journal-title":"Int J Cancer."},{"issue":"7","key":"ref13","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1007\/s10552-011-9779-7","article-title":"Alcohol and tobacco, and the risk of cancers of the upper aerodigestive tract in Latin America: a case-control study","volume":"22","author":"Szyma\u00f1ska K","year":"2011","journal-title":"Cancer Causes Control."},{"issue":"19","key":"ref14","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1056\/NEJMoa065497","article-title":"Case-control study of human papillomavirus and oropharyngeal cancer","volume":"356","author":"D'Souza G","year":"2007","journal-title":"N Engl J Med."},{"issue":"2","key":"ref15","first-page":"599","article-title":"Isoenzimas do CYP450 e biotransforma\u00e7\u00e3o de drogas","volume":"22","author":"Audi EA Pussi FD","year":"2000","journal-title":"Acta Scientiarum."},{"key":"ref16","series-title":"O papel das enzimas CYP2A na susceptibilidade ao c\u00e2ncer de es\u00f4fago e sua regula\u00e7\u00e3o [tese]","author":"Visoni SBC","year":"2009"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"S459","DOI":"10.1080\/14622200701587045","article-title":"Differences in pharmacogenetics of nicotine and alcohol metabolism: review and recommendations for future research","volume":"9 Suppl 3","author":"Wall TL","year":"2007","journal-title":"Nicotine Tob Res."},{"key":"ref18","series-title":"IARC Monographs on the Evaluation of Carcinogenic Risks to Humans: Vol 100E-Tobacco Smoking [monograph on the Internet]","year":"2012"},{"issue":"5990","key":"ref19","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/312169a0","article-title":"Metabolic oxidation phenotypes as markers for susceptibility to lung cancer","volume":"312","author":"Ayesh R","year":"1984","journal-title":"Nature."},{"issue":"1","key":"ref20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/030089161009600101","article-title":"Alcohol, tobacco and genetic susceptibility in relation to cancers of the upper aerodigestive tract in northern Italy","volume":"96","author":"Canova C","year":"2010","journal-title":"Tumori."},{"issue":"7","key":"ref21","doi-asserted-by":"crossref","first-page":"2956","DOI":"10.1158\/0008-5472.CAN-08-2604","article-title":"Genetic associations of 115 polymorphisms with cancers of the upper aerodigestive tract across 10 European countries: the ARCAGE project","volume":"69","author":"Canova C","year":"2009","journal-title":"Cancer Res."},{"key":"ref22","series-title":"DNA - Segredos e Mist\u00e9rios","author":"Farah SB","year":"2007","edition":"2a"},{"issue":"5","key":"ref23","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1111\/j.1472-8206.2010.00889.x","article-title":"Differences between Spaniards and Ecuadorians in CYP2A6 allele frequencies: comparison with other populations","volume":"25","author":"Soriano A","year":"2011","journal-title":"Fundam Clin Pharmacol."},{"issue":"8","key":"ref24","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1080\/00498250600715932","article-title":"CYP2A6 polymorphisms in Malays, Chinese and Indians","volume":"36","author":"Nurfadhlina M","year":"2006","journal-title":"Xenobiotica."},{"key":"ref25","series-title":"The Human Cytochrome P450 (CYP) Allele Nomenclature Database 2007"},{"key":"ref26","series-title":"Cytochrome P450 Homepage 2011","author":"Nelson D"},{"key":"ref27","series-title":"dbSNP Short Genetic variation: NCBI"},{"key":"ref28"},{"key":"ref29","year":"2007"},{"key":"ref30","series-title":"Online Mendelian Inheritance in Man 2012","year":"2012"},{"key":"ref31"},{"issue":"1","key":"ref32","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1080\/07357900802146170","article-title":"CYP1A1 and GSTM1 polymorphisms and oral cancer risk: association studies via evidence-based meta-analyses","volume":"27","author":"Zhuo W","year":"2009","journal-title":"Cancer Invest."},{"key":"ref33","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1186\/1471-2407-10-575","article-title":"The PstI\/RsaI and DraI polymorphisms of CYP2E1 and head and neck cancer risk: a meta-analysis based on 21 case-control studies","volume":"10","author":"Tang K","year":"2010","journal-title":"BMC Cancer."},{"issue":"6","key":"ref34","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1097\/GIM.0b013e3181770196","article-title":"Meta-analysis and pooled analysis of GSTM1 and CYP1A1 polymorphisms and oral and pharyngeal cancers: a HuGE-GSEC review","volume":"10","author":"Varela-Lema L","year":"2008","journal-title":"Genet Med."},{"issue":"2A","key":"ref35","first-page":"1023","article-title":"Lack of association among polymorphic xenobiotic-metabolizing enzyme genotypes and the occurrence and progression of oral carcinoma in a Brazilian population","volume":"28","author":"Losi-Guembarovski R","year":"2008","journal-title":"Anticancer Res."},{"issue":"1","key":"ref36","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/sj.tpj.6500290","article-title":"CYP2A6 genetic polymorphisms and correlation with smoking status in Brazilians","volume":"5","author":"Vasconcelos GM","year":"2005","journal-title":"Pharmacogenomics J."}],"container-title":["Revista do Col\u00e9gio Brasileiro de Cirurgi\u00f5es"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/rcbc\/v41n5\/0100-6991-rcbc-41-05-00366.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T14:22:40Z","timestamp":1598538160000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0100-69912014000500366&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":36,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["S0100-69912014000500366"],"URL":"https:\/\/doi.org\/10.1590\/0100-69912014005012","relation":{},"ISSN":["0100-6991"],"issn-type":[{"value":"0100-6991","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10]]}}}