{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T23:41:15Z","timestamp":1649202075547},"reference-count":24,"publisher":"FapUNIFESP (SciELO)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Col. Bras. Cir."],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:p>ABSTRACT  Objective:  to evaluate the effect of L-lysine in the bladder and intestinal epithelia in rats submitted to vesicosigmoidostomy.  Methods: we divided forty Wistar rats into four groups: group I - control group (Sham); group II - submitted to vesicosigmoidostomy and treated with L-lysine 150mg\/kg; group III - submitted only to vesicosigmoidostomy; and group IV - received L-lysine 150mg\/kg. After eight weeks the animals were sacrificed.  Results:  in the bladders of all operated animals we observed simple, papillary and nodular hyperplasia of transitional cells, transitional cell papillomas and squamous metaplasia. As for the occurrence of aberrant crypt foci in the colons of operated animals, we did not observe statistically significant differences in any of the distal, proximal and medium fragments, or in all fragments together (p=1.0000).  Conclusion: Although statistically there was no promotion of carcinogenesis in the epithelia of rats treated with L-lysine in the observed time, it was clear the histogenesis of bladder carcinogenesis in its initial phase in all operated rats, this being probably associated with chronic infection and tiny bladder stones.<\/jats:p>","DOI":"10.1590\/0100-69912016002003","type":"journal-article","created":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T21:53:39Z","timestamp":1464818019000},"page":"80-86","source":"Crossref","is-referenced-by-count":3,"title":["Bladder carcinogenesis in rats subjected to ureterosigmoidostomy and treated with L-lysine"],"prefix":"10.1590","volume":"43","author":[{"given":"Concei\u00e7\u00e3o Aparecida","family":"Dornelas","sequence":"first","affiliation":[{"name":"Universidade Federal do Cear\u00e1,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra Marques dos","family":"Santos","sequence":"additional","affiliation":[{"name":"Universidade Federal do Cear\u00e1,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio Lucas Oliveira","family":"Correia","sequence":"additional","affiliation":[{"name":"Hospital Geral de Fortaleza,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camila de Carvalho","family":"Juanes","sequence":"additional","affiliation":[{"name":"Universidade Federal do Cear\u00e1,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Paulo Ferreira","family":"Coelho","sequence":"additional","affiliation":[{"name":"Universidade Federal do Cear\u00e1,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bianca Lopes","family":"Cunha","sequence":"additional","affiliation":[{"name":"Universidade Federal do Cear\u00e1,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9 Vinicius Vieira","family":"Maciel","sequence":"additional","affiliation":[{"name":"Universidade Federal do Cear\u00e1,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco Vagnaldo Fechine","family":"Jamacaru","sequence":"additional","affiliation":[{"name":"Universidade Federal do Cear\u00e1,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","first-page":"260","article-title":"Cancer du colon sigmoide dix ans apr\u00e8s implantation des uret\u00e8res d'une vessie exstrophi\u00e9e","volume":"28","author":"Hammer E","year":"1929","journal-title":"J Urol"},{"issue":"6A","key":"ref2","first-page":"3771","article-title":"Correspondence between flat aberrant crypt foci and mucin-depleted foci in rodent colon carcinogenesis","volume":"28","author":"Femia AP","year":"2008","journal-title":"Anticancer 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