{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T19:05:48Z","timestamp":1714417548433},"reference-count":30,"publisher":"FapUNIFESP (SciELO)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Col. Bras. Cir."],"abstract":"<jats:p>ABSTRACT Objective: to analyze the relation of anatomopathological features and axillary involvement in cases of invasive ductal carcinoma. Methods: this is a cross-sectional study of 220 breast cancer patients submitted to radical mastectomy or quadrantectomy with axilar emptying, from the Mastology Service of the Assis Chateaubriand Maternity School, Cear\u00e1, Brazil. We submitted the tumors to histological processing and determined the histological (HG), tubular (TG) and nuclear (NG) grades, and the mitotic index (MI) by the classification of Scarff-Bloom-Richadson, verified the presence of angiolymphatic invasion (AI) and measured the largest tumor diameter (TD). We then correlated these variables with the presence of axillary metastases. Results: the mean patients'age was 56.81 years \u00b1 13.28. Tumor size ranged from 0.13 to 22 cm, with an average of 2.23cm \u00b1 2.79. HG3, TG3 and NG3 prevailed, respectively 107 (48.6%), 160 (72.7%) and 107 (48.6%). Mitotic indexes 1, 2 and 3 presented a homogeneous distribution, respectively 82 (37.2%), 68 (31%) and 70 (31.8%). We observed no relation between the HG, TG and NG with the occurrence of axillary metastases (p=0.07, p=0.22 and p=0.21, respectively). Mitotic indices 2 and 3 were related with the occurrence of axillary metastases (p=0.03). Tumors larger than 2cm and cases that presented angiolymphatic invasion had a higher index of axillary metastases (p=0.0003 and p&lt;0.0001). Conclusion: elevated mitotic indexes, tumors with a diameter greater than 2cm and the presence of angiolymphatic invasion were individuallyassociatedwith the occurrence of axillary metastases.<\/jats:p>","DOI":"10.1590\/0100-69912017002010","type":"journal-article","created":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T17:48:29Z","timestamp":1498240109000},"page":"163-170","source":"Crossref","is-referenced-by-count":6,"title":["Invasive ductal carcinoma: relationship between pathological characteristics and the presence of axillary metastasis in 220 cases"],"prefix":"10.1590","volume":"44","author":[{"given":"RANNIERE GURGEL FURTADO DE","family":"AQUINO","sequence":"first","affiliation":[{"name":"Federal University of Cear\u00e1, Brazil; University of Fortaleza, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PAULO HENRIQUE DI\u00d3GENES","family":"VASQUES","sequence":"additional","affiliation":[{"name":"Federal University of Cear\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DIANE ISABELLE MAGNO","family":"CAVALCANTE","sequence":"additional","affiliation":[{"name":"Federal University of Cear\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AYANE LAYNE DE SOUSA","family":"OLIVEIRA","sequence":"additional","affiliation":[{"name":"University of Fortaleza, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BRUNO MASATO KITAGAWA DE","family":"OLIVEIRA","sequence":"additional","affiliation":[{"name":"Federal University of Ceara, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LUIZ GONZAGA PORTO","family":"PINHEIRO","sequence":"additional","affiliation":[{"name":"Federal University of Cear\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2017,4]]},"reference":[{"issue":"3","key":"ref1","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.soc.2014.03.011","article-title":"Epidemiology of breast cancer","volume":"23","author":"Ban KA","year":"2014","journal-title":"Surg Oncol Clin North Am"},{"issue":"6","key":"ref2","first-page":"326","article-title":"Update of breast cancer in primary care (I\/V)","volume":"40","author":"Vich P","year":"2014","journal-title":"Semergen"},{"issue":"3","key":"ref3","doi-asserted-by":"crossref","first-page":"283","DOI":"10.5306\/wjco.v5.i3.283","article-title":"Pathogenesis, prevention, diagnosis and treatment of breast cancer","volume":"5","author":"Shah R","year":"2014","journal-title":"World J Clin Oncol"},{"issue":"4","key":"ref4","doi-asserted-by":"crossref","first-page":"252","DOI":"10.5935\/1676-2444.20150042","article-title":"Ductal carcinoma of the breast morphological aspects according to the age","volume":"51","author":"Aquino RGF","year":"2015","journal-title":"J Bras Patol Med Lab"},{"issue":"5","key":"ref5","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/j.1365-2559.1991.tb00229.x","article-title":"Pathological prognostic factors in breast cancer I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up","volume":"19","author":"Elston CW","year":"1991","journal-title":"Histopathology"},{"issue":"15","key":"ref6","first-page":"1976","article-title":"Reproducibility of the Nottingham modification of the Scarff-Bloom-Richardson histological grading system and the complementary value of Ki-67 to this system","volume":"123","author":"Zhang R","year":"2010","journal-title":"Chin Med J (Engl)"},{"issue":"4","key":"ref7","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1186\/bcr2607","article-title":"Breast cancer prognostic classification in the molecular era the role of histological grade","volume":"12","author":"Rakha EA","year":"2010","journal-title":"Breast Cancer Res"},{"issue":"1","key":"ref8","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.ejca.2009.09.009","article-title":"ONCOPOOL - a European database for 16,944 cases of breast cancer","volume":"46","author":"Blamey RW","year":"2010","journal-title":"Eur J Cancer"},{"issue":"19","key":"ref9","doi-asserted-by":"crossref","first-page":"3153","DOI":"10.1200\/JCO.2007.15.5986","article-title":"Prognostic significance of Nottingham histologic grade in invasive breast carcinoma","volume":"26","author":"Rakha EA","year":"2008","journal-title":"J Clin Oncol"},{"issue":"4","key":"ref10","first-page":"543","article-title":"Natural course of node-negative breast cancer high risk-related subgroups","volume":"22","author":"Nikolic-Vukosavljevic D","year":"2003","journal-title":"J Exp Clin Cancer Res"},{"issue":"3A","key":"ref11","first-page":"154","article-title":"Pathological prognostic factors in breast cancer I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up","volume":"41","author":"Elston CW","year":"2002","journal-title":"Histopathology"},{"issue":"1","key":"ref12","doi-asserted-by":"crossref","first-page":"82","DOI":"10.5858\/2005-129-82-SNSATC","article-title":"Sentinel node status and tumor characteristics a study of 234 invasive breast carcinomas","volume":"129","author":"Cao Y","year":"2005","journal-title":"Arch Pathol Lab Med"},{"issue":"6","key":"ref13","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S1607-551X(09)70197-4","article-title":"Value of nodal drainage patterns and tumor location from lymphoscintigraphic mapping in detecting axillary sentinel lymph node status in breast cancer experience at Kaohsiung Medical University Hospital","volume":"21","author":"Chen YW","year":"2005","journal-title":"Kaohsiung J Med Sci"},{"key":"ref14","series-title":"Clinical, histomorphological, and therapeutic progmostic factors in patients with triple-negative invasive breast c\u00e2ncer","first-page":"397","volume":"51","author":"Lopes CM","year":"2015"},{"issue":"3","key":"ref15","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1159\/000357781","article-title":"Prognostic factors in 401 elderly women with metastatic breast cancer","volume":"86","author":"Follana P","year":"2014","journal-title":"Oncology"},{"issue":"1","key":"ref16","first-page":"239","article-title":"Histologic grading of breast cancer","volume":"15","author":"Fisher ER","year":"1980","journal-title":"Pathol Annu"},{"issue":"4","key":"ref17","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/BF02968041","article-title":"Pathological approach to evolving prognostic and predictive factors of breast cancer","volume":"11","author":"Arihiro K","year":"2004","journal-title":"Breast Cancer"},{"issue":"7","key":"ref18","doi-asserted-by":"crossref","first-page":"958","DOI":"10.5858\/2000-124-0958-COAPCX","article-title":"College of American Pathologists Conference XXXV solid tumor prognostic factors-which, how and so what? Summary document and recommendations for implementation. Cancer Committee and Conference Participants","volume":"124","author":"Hammond ME","year":"2000","journal-title":"Arch Pathol Lab Med"},{"issue":"7","key":"ref19","first-page":"966","article-title":"Prognostic factors in breast cancer College of American Pathologists Consensus Statement 1999","volume":"124","author":"Fitzgibbons PL","year":"2000","journal-title":"Arch Pathol Lab Med"},{"issue":"1","key":"ref20","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/(SICI)1097-0215(20000120)89:1<26::AID-IJC5>3.0.CO;2-8","article-title":"Cell cycle proteins do not predict outcome in grade I infiltrating ductal carcinoma of the breast","volume":"89","author":"Leong AC","year":"2000","journal-title":"Int J Cancer"},{"issue":"4","key":"ref21","first-page":"601","article-title":"Lack of prognostic significance of histological grade in node-negative invasive breast carcinoma","volume":"3","author":"Younes M","year":"1997","journal-title":"Clin Cancer Res"},{"issue":"3","key":"ref22","doi-asserted-by":"crossref","first-page":"245","DOI":"10.32635\/2176-9745.RBC.2006v52n3.1871","article-title":"Valor progn\u00f3stico do grau histol\u00f3gico (GH), grau nuclear (GN) e \u00edndice mit\u00f3tico (IM) para pacientes com carcinoma da mama est\u00e1dios II e III com linfonodos axilares comprometidos","volume":"52","author":"Lopes LAF","year":"2006","journal-title":"Rev bras cancerol"},{"key":"ref23","first-page":"1","article-title":"Objective malignancy grading a review emphasizing unbiased stereology applied to breast tumors","volume":"79","author":"Ladekarl M","year":"1998","journal-title":"APMIS Suppl"},{"issue":"1A","key":"ref24","first-page":"199","article-title":"Proliferation measurement in breast cancer by two different methods","volume":"26","author":"Mart\u00ednez-Arribas F","year":"2006","journal-title":"Anticancer Res"},{"issue":"11","key":"ref25","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1097\/01.MP.0000093625.20366.9D","article-title":"Prognostic relevance of mitotic activity in patients with node-negative breast cancer","volume":"16","author":"Medri L","year":"2003","journal-title":"Mod Pathol"},{"issue":"5B","key":"ref26","first-page":"3283","article-title":"Analysis of correlation between mitotic index, MIB1 score and S-phase fraction as proliferation markers in invasive breast carcinoma Methodological aspects and prognostic value in a series of 257 cases","volume":"24","author":"Caly M","year":"2004","journal-title":"Anticancer Res"},{"issue":"4","key":"ref27","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/j.1365-2559.1985.tb02826.x","article-title":"The relative prognostic significance of nucleolar morphometry in invasive ductal breast cancer","volume":"9","author":"Baak JP","year":"1985","journal-title":"Histopathology"},{"issue":"6","key":"ref28","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/0046-8177(92)90313-R","article-title":"Reproducibility of mitosis counting in 2,469 breast cancer specimens results from the Multicenter Morphometric Mammary Carcinoma Project","volume":"23","author":"van Diest PJ","year":"1992","journal-title":"Hum Pathol"},{"issue":"3","key":"ref29","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1590\/S0100-72032010000300008","article-title":"Fatores cl\u00ednico-patol\u00f3gicos de predi\u00e7\u00e3o do acometimento axilar em pacientes com met\u00e1stases de c\u00e2ncer de mama no linfonodo sentinela","volume":"32","author":"Barbosa EM","year":"2010","journal-title":"Rev Bras Ginecol Obstet"},{"issue":"11","key":"ref30","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1002\/cncr.11803","article-title":"Clinicopathologic features of metastasis in nonsentinel lymph nodes of breast carcinoma patients","volume":"98","author":"Degnim AC","year":"2003","journal-title":"Cancer"}],"container-title":["Revista do Col\u00e9gio Brasileiro de Cirurgi\u00f5es"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/rcbc\/v44n2\/0100-6991-rcbc-44-02-00163.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T00:33:21Z","timestamp":1659141201000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0100-69912017000200163&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":30,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2017,4]]}},"alternative-id":["S0100-69912017000200163"],"URL":"https:\/\/doi.org\/10.1590\/0100-69912017002010","relation":{},"ISSN":["1809-4546","0100-6991"],"issn-type":[{"value":"1809-4546","type":"electronic"},{"value":"0100-6991","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4]]}}}