{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T13:37:41Z","timestamp":1765805861925},"reference-count":23,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Col. Bras. Cir."],"abstract":"<jats:p>RESUMO Objetivo: avaliar a efic\u00e1cia de tr\u00eas marcadores imunoistoqu\u00edmicos envolvidos no processo de cicatriza\u00e7\u00e3o de ferida cir\u00fargica. M\u00e9todos: estudo experimental em 40 ratos da ra\u00e7a Wistar, dos marcadores metaloproteinases e metaloproteinase da matriz 9 (MMP-9), fator de transforma\u00e7\u00e3o do crescimento beta (TGF-\u03b2) e miofibroblasto e alfa actina de m\u00fasculo liso (\u03b1-AML), estudados a partir de fragmentos de cicatriz cir\u00fargica de incis\u00e3o abdominal envolvendo pele, aponeurose e perit\u00f4nio. Os animais foram distribu\u00eddos em quatro subgrupos de dez de acordo com o dia da morte, programada em tr\u00eas, sete, 14 e 21 dias. Resultados: na express\u00e3o da MMP-9 ocorreu aumento progressivo de sua concentra\u00e7\u00e3o, mais evidente do 7\u00ba ao 14\u00ba dias variando a imuno-express\u00e3o tecidual entre 2,65% e 11,50%.TGF- \u03b2 mostrou express\u00e3o em n\u00edvel alto no 3\u00ba dia, caiu no 7\u00ba, voltando a subir no 14\u00ba, com pequena queda no 21\u00ba dia variando a imuno-express\u00e3o tecidual entre 0,03% e 2,92%. A \u03b1-AML apresentou n\u00edveis com pouca varia\u00e7\u00e3o e discreto aumento variando a imuno-express\u00e3o tecidual entre 0,88% e 3,23%. Conclus\u00e3o: a MMP-9 se apresentou como melhor marcador, seguido pela TGF-\u03b2. J\u00e1 o \u03b1-AML n\u00e3o se mostrou um bom sinalizador da evolu\u00e7\u00e3o da repara\u00e7\u00e3o tissular.<\/jats:p>","DOI":"10.1590\/0100-69912017004011","type":"journal-article","created":{"date-parts":[[2017,10,4]],"date-time":"2017-10-04T23:26:32Z","timestamp":1507159592000},"page":"367-373","source":"Crossref","is-referenced-by-count":2,"title":["Avalia\u00e7\u00e3o da efic\u00e1cia de tr\u00eas marcadores imunoistoqu\u00edmicos envolvidos nos diferentes tempos da cicatriza\u00e7\u00e3o da ferida cir\u00fargica"],"prefix":"10.1590","volume":"44","author":[{"given":"Oct\u00e1vio Antonio Azevedo da","family":"Costa Filho","sequence":"first","affiliation":[{"name":"Faculdade Evang\u00e9lica do Paran\u00e1, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jurandir Marcondes","family":"Ribas Filho","sequence":"additional","affiliation":[{"name":"Faculdade Evang\u00e9lica do Paran\u00e1, 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