{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T16:18:27Z","timestamp":1787933907175,"version":"build-2784847793"},"reference-count":53,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Col. Bras. Cir."],"abstract":"<jats:p>RESUMO Objetivo: estudar a condroradionecrose de laringe por complica\u00e7\u00e3o de radio-quimioterapia para tratamento do c\u00e2ncer de laringe e propor um fluxograma de tratamento com a utiliza\u00e7\u00e3o de c\u00e2mara hiperb\u00e1rica. M\u00e9todos: estudo retrospectivo de pacientes portadores de carcinoma de laringe admitidos em dois hospitais terci\u00e1rios num per\u00edodo de cinco anos. Resultados: de 131 pacientes portadores de c\u00e2ncer de laringe, 28 foram submetidos \u00e0 radio e quimioterapia exclusiva e destes, tr\u00eas evolu\u00edram com condroradionecrose. O tratamento destes pacientes foi realizado com c\u00e2mara hiperb\u00e1rica e com desbridamento cir\u00fargico, conforme proposi\u00e7\u00e3o do fluxograma. Todos os pacientes tiveram a laringe preservada. Conclus\u00e3o: a incid\u00eancia de condroradionecrose de laringe por complica\u00e7\u00e3o de radioterapia e quimioterapia em nossa casu\u00edstica foi de 10,7% e o tratamento com oxigenoterapia hiperb\u00e1rica, com base no nosso fluxograma, foi efetivo no controle desta complica\u00e7\u00e3o.<\/jats:p>","DOI":"10.1590\/0100-69912017004012","type":"journal-article","created":{"date-parts":[[2017,10,4]],"date-time":"2017-10-04T23:26:09Z","timestamp":1507159569000},"page":"374-382","source":"Crossref","is-referenced-by-count":9,"title":["Condroradionecrose de laringe ap\u00f3s radioterapia"],"prefix":"10.1590","volume":"44","author":[{"given":"Giulianno Molina","family":"Melo","sequence":"first","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo, Brazil; Hospital da Benefic\u00eancia Portuguesa de S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula Demetrio","family":"Souza","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo, Brazil; Hospital da Benefic\u00eancia Portuguesa de S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Castro","family":"Bastos Filho","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murilo Catafesta","family":"Neves","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kleber Sim\u00f5es do","family":"Espirito Santo","sequence":"additional","affiliation":[{"name":"Hospital da Benefic\u00eancia Portuguesa de S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Onivaldo","family":"Cervantes","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rcio","family":"Abrah\u00e3o","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2017,8]]},"reference":[{"key":"ref1","series-title":"Larynx - Estimated incidence, all ages: male","year":"2012"},{"issue":"2","key":"ref2","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2013-003736","article-title":"The magnitude of the association between smoking and the risk of developing cancer in Brazil: a multicenter study","volume":"4","author":"Moura MA","year":"2014","journal-title":"BMJ Open"},{"key":"ref3","series-title":"Cancer Stat Fact Sheets: larynx cancer","year":"2016"},{"key":"ref4","series-title":"Estimativa 2014: Incid\u00eancia de c\u00e2ncer no Brasil","year":"2014"},{"issue":"10","key":"ref5","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1093\/jnci\/djk179","article-title":"Alcohol drinking in never users of tobacco, cigarette smoking in never drinkers, and the risk of head and neck cancer: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium","volume":"99","author":"Hashibe M","year":"2007","journal-title":"J Natl Cancer Inst"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"F34","DOI":"10.1016\/j.vaccine.2012.05.070","article-title":"Human papillomavirus and diseases of the upper airway: head and neck cancer and respiratory papillomatosis","volume":"30","author":"Gillison ML","year":"2012","journal-title":"Vaccine"},{"issue":"10","key":"ref7","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1097\/00005537-200210000-00030","article-title":"The role of acid and alkaline reflux in laryngeal squamous cell carcinoma","volume":"112","author":"Galli J","year":"2002","journal-title":"Laryngoscope"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"S56","DOI":"10.1038\/bjc.2012.119","article-title":"Occupational cancer in Britain. 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