{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T23:12:08Z","timestamp":1725059528539},"reference-count":17,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Col. Bras. Cir."],"abstract":"<jats:p>RESUMO Objetivo: avaliar os fatores de risco para presen\u00e7a de doen\u00e7a metast\u00e1tica axilar n\u00e3o sentinela em pacientes com c\u00e2ncer de mama e bi\u00f3psia do linfonodo sentinela positiva. M\u00e9todos: estudo transversal, retrospectivo, de mulheres com c\u00e2ncer mam\u00e1rio operadas no Instituto do C\u00e2ncer do Cear\u00e1, entre os anos de 2002 e 2012 e submetidas \u00e0 bi\u00f3psia de linfonodo sentinela. Resultados: de 946 pacientes com c\u00e2ncer de mama, 331 foram submetidas \u00e0 bi\u00f3psia de linfonodo sentinela, que foi positiva em 83. Estas foram submetidas \u00e0 linfadenectomia axilar e 39 (46%) apresentaram met\u00e1stases em outros linfonodos axilares. As vari\u00e1veis que foram significantes para doen\u00e7a axilar adicional foram Ki67&gt;14 (p=0,043), presen\u00e7a de invas\u00e3o angiolinf\u00e1tica (p=0,01) e tamanho tumoral (p=0,027). N\u00e3o foi observado associa\u00e7\u00e3o com receptores de estrog\u00eanio, progesterona, grau tumoral e Her-2. Discuss\u00e3o: a presen\u00e7a de invas\u00e3o angiolinf\u00e1tica e tamanho tumoral tamb\u00e9mj\u00e1foram relacionados \u00e0 met\u00e1stase axilar adicional em outros estudos. Al\u00e9m destas vari\u00e1veis observou-se o mesmo efeito preditivo quando avaliamos o Ki67. A valida\u00e7\u00e3o destes resultados poder\u00e1 permitira customiza\u00e7\u00e3o do tratamento do c\u00e2ncer de mama, podendo reduzir sua morbidade. Conclus\u00e3o: invas\u00e3o angiolinf\u00e1tica, tamanho tumoral (T3\/T4) e Ki67&gt;14 foram fatores preditivos de acometimento de met\u00e1stase axilar al\u00e9m do linfonodo sentinela.<\/jats:p>","DOI":"10.1590\/0100-69912017004014","type":"journal-article","created":{"date-parts":[[2017,10,4]],"date-time":"2017-10-04T23:26:05Z","timestamp":1507159565000},"page":"391-396","source":"Crossref","is-referenced-by-count":6,"title":["Fatores preditivos de met\u00e1stases axilares em pacientes com c\u00e2ncer de mama e bi\u00f3psia de linfonodo sentinela positivo"],"prefix":"10.1590","volume":"44","author":[{"given":"Ol\u00edvio Feitosa","family":"Costa Neto","sequence":"first","affiliation":[{"name":"Instituto do C\u00e2ncer do Cear\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael Bustamante","family":"Castro","sequence":"additional","affiliation":[{"name":"Instituto do C\u00e2ncer do Cear\u00e1, 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