{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T14:25:10Z","timestamp":1648995910855},"reference-count":22,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Col. Bras. Cir."],"abstract":"<jats:p>RESUMO Objetivo: estudar a efic\u00e1cia e seguran\u00e7a do uso de acetato de triancinolona subconjuntival isolado ou em associa\u00e7\u00e3o \u00e0 mitomicina C como modulador da cicatriza\u00e7\u00e3o de trabeculectomias em coelhos. M\u00e9todos: trinta coelhos machos, albinos, ra\u00e7a Nova Zel\u00e2ndia foram submetidos \u00e0 trabeculectomia bilateralmente. Os animais foram divididos em quatro grupos experimentais com 15 olhos por grupo: controle, mitomicina C, acetato de triancinolona e acetato de triancinolona + mitomicina C. Tonometria de aplana\u00e7\u00e3o e an\u00e1lise cl\u00ednica da bolha atrav\u00e9s do Sistema de Gradua\u00e7\u00e3o de Moorfields foram obtidas no p\u00f3s-operat\u00f3rio. Para a avalia\u00e7\u00e3o da cicatriza\u00e7\u00e3o, procedeu-se \u00e0 an\u00e1lise quantitativa do infiltrado inflamat\u00f3rio (polimorfonucleares) atrav\u00e9s da colora\u00e7\u00e3o Hematoxilina &amp; Eosina e da prolifera\u00e7\u00e3o vascular por imuno-histoqu\u00edmica. Resultados: foi observada em todos os grupos diminui\u00e7\u00e3o significativa da press\u00e3o intraocular p\u00f3s-operat\u00f3ria em rela\u00e7\u00e3o \u00e0 pr\u00e9-operat\u00f3ria (p&lt;0,001). Contudo, n\u00e3o houve diferen\u00e7a entre os grupos (p=0,186). O grupo acetato de triancinolona + mitomicina C apresentou melhores \u00edndices na altura m\u00e1xima da bolha e na vasculariza\u00e7\u00e3o da \u00e1rea central da bolha (p=0,001); al\u00e9m disso, houve menor resposta inflamat\u00f3ria (p=0,001) e menor prolifera\u00e7\u00e3o vascular (p=0,001) na fase intermedi\u00e1ria do estudo em rela\u00e7\u00e3o \u00e0s monoterapias. Conclus\u00e3o: a associa\u00e7\u00e3o da mitomicina C ao acetato de triancinolona resultou numa a\u00e7\u00e3o sin\u00e9rgica entre esses agentes, com bolhas mais amplas e difusas e menor infiltrado inflamat\u00f3rio e menor prolifera\u00e7\u00e3o vascular em est\u00e1gio intermedi\u00e1rio do acompanhamento neste modelo animal.<\/jats:p>","DOI":"10.1590\/0100-6991e-20181861","type":"journal-article","created":{"date-parts":[[2018,7,30]],"date-time":"2018-07-30T20:10:56Z","timestamp":1532981456000},"source":"Crossref","is-referenced-by-count":1,"title":["Modula\u00e7\u00e3o da cicatriza\u00e7\u00e3o na cirurgia do glaucoma ap\u00f3s aplica\u00e7\u00e3o de acetato de triancinolona subconjuntival isolado ou em associa\u00e7\u00e3o \u00e0 mitomicina C: estudo experimental"],"prefix":"10.1590","volume":"45","author":[{"given":"Hayana Marques do Arag\u00e3o","family":"Rangel","sequence":"first","affiliation":[{"name":"Universidade Federal de Minas Gerais, Brasil; Santa Casa de Miseric\u00f3rdia de Belo Horizonte, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9vila Tamar","family":"Rolim","sequence":"additional","affiliation":[{"name":"Santa Casa de Miseric\u00f3rdia de Belo Horizonte, Brasil; 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I. Trabeculectomy following subconjunctival triamcinolone","volume":"104","author":"Giangiacomo J","year":"1986","journal-title":"Arch Ophthalmol"},{"issue":"12","key":"ref15","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1038\/sj.eye.6702372","article-title":"Intrableb triamcinolone acetonide injection after bleb-forming filtration surgery (trabeculectomy, phacotrabeculectomy, and trabeculectomy revision by needling): a pilot study","volume":"20","author":"Tham CC","year":"2006","journal-title":"Eye (Lond)"},{"key":"ref16","first-page":"29","article-title":"Trabeculectomy with intraoperative retrobulbar triamcinolone acetonide","volume":"3","author":"Kahook MY","year":"2009","journal-title":"Clin Ophthalmol"},{"issue":"6","key":"ref17","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/j.ajo.2009.01.007","article-title":"Trabeculectomy with or without intraoperative sub-tenon injection of triamcinolone acetonide in treating secondary glaucoma","volume":"147","author":"Yuki K","year":"2009","journal-title":"Am J Ophthalmol"},{"issue":"4","key":"ref18","doi-asserted-by":"crossref","first-page":"169","DOI":"10.4274\/tjo.88785","article-title":"The effect of adjuvant intracameral triamcinolone acetonide on the surgical results of trabeculectomy with mitomycin C","volume":"46","author":"Alag\u00f6z N","year":"2016","journal-title":"Turk J Ophthalmol"},{"issue":"8","key":"ref19","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1097\/IJG.0000000000000194","article-title":"Efficacy of adjunctive subconjunctival bevacizumab on the outcomes of primary trabeculectomy with mitomycin C: a prospective randomized placebo-controlled trial","volume":"24","author":"Kiddee W","year":"2015","journal-title":"J Glaucoma"},{"issue":"12","key":"ref20","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1016\/S0161-6420(95)30797-X","article-title":"A ten-year follow-up on a prospective, randomized trial of postoperative corticosteroids after trabeculectomy","volume":"102","author":"Araujo SV","year":"1995","journal-title":"Ophthalmology"},{"issue":"9","key":"ref21","first-page":"2693","article-title":"Effect of steroids and nonsteroidal anti-inflammatory agents on human ocular fibroblast","volume":"33","author":"Nguyen KD","year":"1992","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"ref22","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s12013-015-0566-z","article-title":"Bevacizumab inhibits angiogenesis and inflammation in rat filtration surgery model","volume":"73","author":"Cheng G","year":"2015","journal-title":"Cell Biochem Biophys"}],"container-title":["Revista do Col\u00e9gio Brasileiro de Cirurgi\u00f5es"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/rcbc\/v45n4\/0100-6991-rcbc-45-04-e1861.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T14:26:41Z","timestamp":1571668001000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0100-69912018000400151&lng=pt&tlng=pt"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,30]]},"references-count":22,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2018]]}},"alternative-id":["S0100-69912018000400151"],"URL":"https:\/\/doi.org\/10.1590\/0100-6991e-20181861","relation":{},"ISSN":["1809-4546","0100-6991"],"issn-type":[{"value":"1809-4546","type":"electronic"},{"value":"0100-6991","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7,30]]}}}