{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T09:51:10Z","timestamp":1756461070708},"reference-count":38,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Col. Bras. Cir."],"abstract":"<jats:p>RESUMO A terap\u00eautica inadequada da dor p\u00f3s-operat\u00f3ria em colecistectomia videolaparosc\u00f3pica pode levar a mobiliza\u00e7\u00e3o tardia, insatisfa\u00e7\u00e3o do paciente, atraso na alta hospitalar e desenvolvimento de dor cr\u00f4nica. Objetivou-se identificar qual a melhor estrat\u00e9gia terap\u00eautica dispon\u00edvel ao anestesiologista na terapia da dor aguda p\u00f3s-operat\u00f3ria de pacientes submetidos \u00e0 colecistectomia videolaparosc\u00f3pica eletiva. Trata-se de revis\u00e3o sistem\u00e1tica que incluiu 36 artigos completos indexados nas bases de dados Medline, Scopus, Web of Science e LILACS, com recorte temporal de cinco anos (2012 a 2016), resultantes de estudos controlados e randomizados que foram submetidos \u00e0 an\u00e1lise qualitativa. Em uma proposta de analgesia multimodal, \u00e9 importante considerar as contraindica\u00e7\u00f5es, os efeitos adversos, a dose e o momento ideal das interven\u00e7\u00f5es. Utiliza-se f\u00e1rmacos n\u00e3o opioides, como anti-inflamat\u00f3rios n\u00e3o esteroides (AINES)\/inibidores da ciclo-oxigenase-2 (COX-2), gabapentina\/pregabalina, antagonistas dos receptores N-methyl-D-aspartato (NMDA), entre outras. Os opioides podem ser utilizados em doses baixas associadas ou n\u00e3o a terapia multimodal e\/ou ficarem restritos aos casos em que a analgesia multimodal n\u00e3o opioide for insuficiente. Conclui-se que n\u00e3o h\u00e1 consenso sobre qual a melhor estrat\u00e9gia analg\u00e9sica a ser implementada na dor aguda p\u00f3s-operat\u00f3ria da colecistectomia videolaparosc\u00f3pica, o que requer sua aplicabilidade de forma individualizada, com base nas evid\u00eancias cient\u00edficas encontradas na literatura. Aponta-se como contribui\u00e7\u00f5es para o ensino e a pr\u00e1tica profissional o enriquecimento te\u00f3rico das op\u00e7\u00f5es medicamentosas analg\u00e9sicas dispon\u00edveis para a terap\u00eautica da dor p\u00f3s-operat\u00f3ria de pacientes submetidos \u00e0 colecistectomia videolaparosc\u00f3pica eletiva, al\u00e9m de alertar a equipe para considerar os efeitos adversos das interven\u00e7\u00f5es implementadas.<\/jats:p>","DOI":"10.1590\/0100-6991e-20181885","type":"journal-article","created":{"date-parts":[[2018,7,30]],"date-time":"2018-07-30T20:07:18Z","timestamp":1532981238000},"source":"Crossref","is-referenced-by-count":4,"title":["Terap\u00eautica anest\u00e9sica para o al\u00edvio da dor aguda p\u00f3s-colecistectomia videolaparosc\u00f3pica: revis\u00e3o sistem\u00e1tica."],"prefix":"10.1590","volume":"45","author":[{"given":"Renato Ribeiro de","family":"Jesus","sequence":"first","affiliation":[{"name":"Universidade Federal do Rio de Janeiro, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adebaldo Maia","family":"Leite","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone Soares","family":"Leite","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rcio Carneiro","family":"Vieira","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nivaldo Ribeiro","family":"Villela","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro, Brasil; Universidade do Estado do Rio de Janeiro, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2018,7,30]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jclinane.2016.02.020","article-title":"Comparison of postoperative analgesic efficacy of intraoperative single-dose intravenous administration of dexketoprofen trometamol and diclofenac sodium in laparoscopic cholecystectomy","volume":"32","author":"Anil A","year":"2016","journal-title":"J Clin Anesth"},{"issue":"3","key":"ref2","first-page":"191","article-title":"Opioid-free total intravenous anesthesia with propofol, dexmedetomidine and lidocaine infusions for laparoscopic cholecystectomy: a prospective, randomized, double-blinded study","volume":"65","author":"Bakan M","year":"2015","journal-title":"Rev Bras Anestesiol"},{"issue":"3","key":"ref3","first-page":"145","article-title":"Randomized, controlled trial comparing the effects of anesthesia with propofol, isoflurane, desflurane and sevoflurane on pain after laparoscopic cholecystectomy","volume":"64","author":"Ortiz J","year":"2014","journal-title":"Rev Braz Anesthesiol"},{"issue":"10","key":"ref4","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1111\/j.1477-2574.2011.00371.x","article-title":"A systematic review of interventions to facilitate ambulatory laparoscopic cholecystectomy","volume":"13","author":"Ahn Y","year":"2011","journal-title":"HPB (Oxford)"},{"issue":"4","key":"ref5","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1097\/00000542-200604000-00030","article-title":"Analgesic treatment after laparoscopic cholecystectomy: a critical assessment of the evidence","volume":"104","author":"Bisgaard T","year":"2006","journal-title":"Anesthesiology"},{"issue":"2","key":"ref6","doi-asserted-by":"crossref","first-page":"335","DOI":"10.5123\/S1679-49742015000200017","article-title":"Principais itens para relatar revis\u00f5es sistem\u00e1ticas e meta-an\u00e1lises a recomenda\u00e7\u00e3o PRISMA","volume":"24","author":"Galv\u00e3o TF","year":"2015","journal-title":"Epidemiol Serv Sa\u00fade"},{"issue":"2","key":"ref7","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1002\/ejp.699","article-title":"No effect of the cyclooxygenase-2 inhibitor etoricoxib on pre-emptive and post-operative analgesia in visceral surgery results of a randomized controlled trial","volume":"20","author":"Fleckenstein J","year":"2016","journal-title":"Eur J Pain"},{"issue":"5","key":"ref8","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.ijsu.2014.03.013","article-title":"Preoperative intravenous parecoxib reduces length of stay on ambulatory laparoscopic cholecystectomy","volume":"12","author":"Shuying L","year":"2014","journal-title":"Int J Surg"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"278","DOI":"10.3344\/kjp.2014.27.3.278","article-title":"Evaluation of the efficacy of methylprednisolone, etoricoxib and a combination of the two substances to attenuate postoperative pain and PONV in patients undergoing laparoscopic cholecystectomy a prospective, randomized, placebo-controlled trial","volume":"27","author":"Gautam S","year":"2014","journal-title":"Korean J Pain"},{"issue":"4","key":"ref10","doi-asserted-by":"crossref","first-page":"485","DOI":"10.4103\/0970-9185.119144","article-title":"Comparison between lornoxicam quick-release and parecoxib for post-operative analgesia after laparoscopic cholecystectomy a prospective randomized, placebo-controlled trial","volume":"29","author":"Kouroukli I","year":"2013","journal-title":"J Anaesthesiol Clin Pharmacol"},{"issue":"1","key":"ref11","doi-asserted-by":"crossref","first-page":"214","DOI":"10.5812\/aapm.9880","article-title":"Intravenous paracetamol for postoperative analgesia in laparoscopic cholecystectomy","volume":"3","author":"Gousheh SM","year":"2013","journal-title":"Anesth Pain Med"},{"issue":"3","key":"ref12","first-page":"187","article-title":"Infusional therapy: an alternative for shouder pain post-laparoscopy","volume":"81","author":"Ure\u00f1a-Frausto CA","year":"2013","journal-title":"Cir Cir"},{"issue":"2","key":"ref13","doi-asserted-by":"crossref","first-page":"63","DOI":"10.5505\/agri.2012.71501","article-title":"The efficacy of adding dexketoprofen trometamol to tramadol with patient controlled analgesia technique in post-laparoscopic cholecystectomy pain treatment","volume":"24","author":"Ekmek\u00e7i P","year":"2012","journal-title":"Agri"},{"issue":"4","key":"ref14","doi-asserted-by":"crossref","first-page":"452","DOI":"10.4328\/JCAM.2161","article-title":"Effects of subanesthetic ketamine on pain and cognitive functions in TIVA","volume":"6","author":"Ozhan Y","year":"2015","journal-title":"J Clin Anal Med"},{"issue":"2","key":"ref15","doi-asserted-by":"crossref","first-page":"169","DOI":"10.4103\/0970-9185.155143","article-title":"Role of flupirtine as a preemptive analgesic in patients undergoing laparoscopic cholecystectomy","volume":"31","author":"Yadav G","year":"2015","journal-title":"J Anaesthesiol Clin Pharmacol"},{"issue":"3","key":"ref16","first-page":"289","article-title":"The effect of preemptive intravenous low-dose magnesium sulfate on early postoperative pain after laparoscopic cholecystectomy","volume":"52","author":"Kocman IB","year":"2013","journal-title":"Acta Clin Croat"},{"issue":"2","key":"ref17","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/S0034-7094(13)70211-3","article-title":"Assessment of the effect of ketamine in combination with remifentanil on postoperative pain","volume":"63","author":"Leal PC","year":"2013","journal-title":"Braz J Anesthesiol"},{"issue":"2","key":"ref18","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1097\/SLE.0b013e3182827f09","article-title":"Addition of ketamine to propofol-alfentanil anesthesia may reduce postoperative pain in laparoscopic cholecystectomy","volume":"23","author":"Karcioglu M","year":"2013","journal-title":"Surg Laparosc Endosc Percutan Tech"},{"issue":"4","key":"ref19","doi-asserted-by":"crossref","first-page":"478","DOI":"10.4103\/0970-9185.119141","article-title":"Preemptive analgesia with Ketamine for Laparoscopic cholecystectomy","volume":"29","author":"Singh H","year":"2013","journal-title":"J Anaesthesiol Clin Pharmacol"},{"issue":"3","key":"ref20","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1097\/SLE.0b013e31824f8ae4","article-title":"Preemptive use of diclofenac in combination with ketamine in patients undergoing laparoscopic cholecystectomy: a randomized, double-blind, placebo-controlled study","volume":"22","author":"Nesek-Adam V","year":"2012","journal-title":"Surg Laparosc Endosc Percutan Tech"},{"issue":"2","key":"ref21","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1684\/mrh.2012.0315","article-title":"The effects of magnesium sulphate on desflurane requirement, early recovery and postoperative analgesia in laparascopic cholecystectomy","volume":"25","author":"Olgun B","year":"2012","journal-title":"Magnes Res"},{"issue":"1","key":"ref22","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1007\/s00540-015-2078-9","article-title":"The effect of pregabalin and celecoxib on the analgesic requirements after laparoscopic cholecystectomy a randomized controlled trial","volume":"30","author":"Gurunathan U","year":"2016","journal-title":"J Anesth"},{"issue":"11","key":"ref23","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1097\/AJP.0000000000000060","article-title":"Clinical study evaluating pregabalin efficacy and tolerability for pain management in patients undergoing laparoscopic cholecystectomy","volume":"30","author":"Bekawi MS","year":"2014","journal-title":"Clin J Pain"},{"issue":"7","key":"ref24","doi-asserted-by":"crossref","first-page":"2504","DOI":"10.1007\/s00464-012-2769-3","article-title":"Effect of pre-emptive pregabalin on pain intensity and postoperative morphine consumption after laparoscopic cholecystectomy","volume":"27","author":"Sarakatsianou C","year":"2013","journal-title":"Surg Endosc"},{"issue":"3","key":"ref25","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.jclinane.2011.06.027","article-title":"A randomized, placebo-controlled study of pregabalin for postoperative pain intensity after laparoscopic cholecystectomy","volume":"24","author":"Balaban F","year":"2012","journal-title":"J Clin Anesth"},{"issue":"2","key":"ref26","first-page":"141","article-title":"Effect of intraoperative esmolol infusion on anesthetic, analgesic requirements and postoperative nausea-vomitting in a group of laparoscopic cholecystectomy patients","volume":"65","author":"Dereli N","year":"2015","journal-title":"Rev Bras Anestesiol"},{"issue":"3","key":"ref27","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.jclinane.2014.11.016","article-title":"Effect of acute arterial hypertension on morphine requirements and postsurgical pain","volume":"27","author":"Delfino AE","year":"2015","journal-title":"J Clin Anesth"},{"issue":"1","key":"ref28","first-page":"25","article-title":"A comparison of the effects of intraoperative esmolol and lidocaine infusions on postoperative analgesia","volume":"22","author":"Akelma FK","year":"2014","journal-title":"Anestezi Dergisi"},{"issue":"4","key":"ref29","doi-asserted-by":"crossref","first-page":"361","DOI":"10.3344\/kjp.2013.26.4.361","article-title":"The analgesic effect of nefopam with fentanyl at the end of laparoscopic cholecystectomy","volume":"26","author":"Lee JH","year":"2013","journal-title":"Korean J Pain"},{"issue":"5","key":"ref30","doi-asserted-by":"crossref","first-page":"436","DOI":"10.4097\/kjae.2012.63.5.436","article-title":"Does dexmedetomidine reduce postoperative pain after laparoscopic cholecystectomy with multimodal analgesia","volume":"63","author":"Park JK","year":"2012","journal-title":"Korean J Anesthesiol"},{"issue":"5","key":"ref31","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1007\/s12630-012-9684-x","article-title":"Esmolol versus ketamine-remifentanil combination for early postoperative analgesia after laparoscopic cholecystectomy a randomized controlled trial","volume":"59","author":"L\u00f3pez-\u00c1lvarez S","year":"2012","journal-title":"Can J Anaesth"},{"issue":"2","key":"ref32","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.jamcollsurg.2015.03.030","article-title":"Efficacy of a laparoscopically delivered transversus abdominis plane block technique during elective laparoscopic cholecystectomy a prospective, double-blind randomized trial","volume":"221","author":"Elamin G","year":"2015","journal-title":"J Am Coll Surg"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.12659\/MSM.893593","article-title":"Analgesia and respiratory function after laparoscopic cholecystectomy in patients receiving ultrasound-guided bilateral oblique subcostal transversus abdominis plane block a randomized double-blind study","volume":"21","author":"Basaran B","year":"2015","journal-title":"Med Sci Monit"},{"issue":"9","key":"ref34","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.14260\/jemds\/2015\/205","article-title":"Comparative study between levobupivacaine with clonidine and ropivacaine with clonidine in thoracic epidural block for laparoscopic cholecystectomy","volume":"4","author":"Pandey A","year":"2015","journal-title":"J Evolution Med Dent Sci"},{"issue":"4","key":"ref35","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.jclinane.2013.11.023","article-title":"Comparison of posterior and subcostal approach to ultrasound-guided transverse abdominis plane block for postoperative analgesia in laparoscopic cholecystectomy","volume":"26","author":"Bhatia N","year":"2014","journal-title":"J Clin Anesth"},{"issue":"3","key":"ref36","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1213\/ANE.0b013e318261f16e","article-title":"The beneficial effect of transversus abdominis plane block after laparoscopic cholecystectomy in day-case surgery a randomized clinical trial","volume":"115","author":"Petersen PL","year":"2012","journal-title":"Anesth Analg"},{"issue":"6","key":"ref37","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1177\/0300060515594194","article-title":"Efficacy of early intravenous bolus oxycodone or fentanyl in emergence from general anaesthesia and postoperative analgesia following laparoscopic cholecystectomy a randomized trial","volume":"43","author":"Choi YJ","year":"2015","journal-title":"J Int Med Res"},{"issue":"7","key":"ref38","doi-asserted-by":"crossref","first-page":"658","DOI":"10.7150\/ijms.8331","article-title":"Oxycodone vs fentanyl patient-controlled analgesia after laparoscopic cholecystectomy","volume":"11","author":"Hwang BY","year":"2014","journal-title":"Int J Med Sci"}],"container-title":["Revista do Col\u00e9gio Brasileiro de Cirurgi\u00f5es"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/rcbc\/v45n4\/0100-6991-rcbc-45-04-e1885.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,28]],"date-time":"2022-08-28T13:09:33Z","timestamp":1661692173000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0100-69912018000400300&lng=pt&tlng=pt"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,30]]},"references-count":38,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2018]]}},"alternative-id":["S0100-69912018000400300"],"URL":"https:\/\/doi.org\/10.1590\/0100-6991e-20181885","relation":{},"ISSN":["1809-4546","0100-6991"],"issn-type":[{"value":"1809-4546","type":"electronic"},{"value":"0100-6991","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7,30]]}}}