{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T10:29:11Z","timestamp":1788863351425,"version":"build-2803163510"},"reference-count":23,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Col. Bras. Cir."],"abstract":"<jats:p>RESUMO A carcinomatose peritoneal \u00e9 a evolu\u00e7\u00e3o natural das neoplasias gastrointestinais, ginecol\u00f3gicas e prim\u00e1rias do perit\u00f4nio. Nos \u00faltimos anos, a carcinomatose passou a ser considerada uma doen\u00e7a confinada ao perit\u00f4nio, e n\u00e3o mais uma doen\u00e7a disseminada. Desta forma, a associa\u00e7\u00e3o de citorredu\u00e7\u00e3o cir\u00fargica associada \u00e0 quimioterapia intraperitoneal se tornou o ponto chave no controle das met\u00e1stases peritoneais. Tradicionalmente, a quimioterapia intraperitoneal \u00e9 aplicada utilizando solu\u00e7\u00f5es l\u00edquidas. Uma nova modalidade de infus\u00e3o da quimioterapia na cavidade abdominal surge como uma alternativa ao m\u00e9todo tradicional. A chamada PIPAC (Pressurized Intraperitoneal Aerosol Chemotherapy) transforma a solu\u00e7\u00e3o terap\u00eautica l\u00edquida em um spray aerossolizado, potencializando a distribui\u00e7\u00e3o e penetra\u00e7\u00e3o da quimioterapia intraperitoneal. Este relato tem por objetivo descrever essa nova t\u00e9cnica cir\u00fargica inovadora, realizada pela primeira vez por um monoportal no Brasil, alterando a forma descrita originalmente para a aplica\u00e7\u00e3o da PIPAC.<\/jats:p>","DOI":"10.1590\/0100-6991e-20181909","type":"journal-article","created":{"date-parts":[[2018,8,18]],"date-time":"2018-08-18T17:02:50Z","timestamp":1534611770000},"source":"Crossref","is-referenced-by-count":9,"title":["Quimioterapia Aerossolizada e Pressurizada Intraperitoneal (PIPAC) por monoportal: aplica\u00e7\u00e3o alternativa no controle das met\u00e1stases peritoneais."],"prefix":"10.1590","volume":"45","author":[{"given":"Rafael","family":"Seitenfus","sequence":"first","affiliation":[{"name":"Hospital Santa Rita,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Nocchi","family":"Kalil","sequence":"additional","affiliation":[{"name":"Hospital Santa Rita,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo Dipp","family":"de-Barros","sequence":"additional","affiliation":[{"name":"Hospital Santa Rita,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme","family":"Fedrizzi","sequence":"additional","affiliation":[{"name":"Hospital Santa Rita,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2018,8,20]]},"reference":[{"issue":"3","key":"ref1","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1111\/j.1749-6632.1958.tb42669.x","article-title":"The intraperitoneal use of nitrogen mustard at the time of operation for cancer","volume":"68","author":"Economou SG","year":"1958","journal-title":"Ann N Y Acad Sci"},{"issue":"26","key":"ref2","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1056\/NEJM199612263352603","article-title":"Intraperitoneal cisplatin plus intravenous cyclophosphamide versus intravenous cisplatin plus intravenous cyclophosphamide for stage III ovarian cancer","volume":"335","author":"Alberts DS","year":"1996","journal-title":"N Engl J Med"},{"issue":"1","key":"ref3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1056\/NEJM199601043340101","article-title":"Cyclophosphamide and cisplatin compared with paclitaxel and cisplatin in patients with stage III and stage IV ovarian cancer","volume":"334","author":"McGuire WP","year":"1996","journal-title":"N Engl J Med"},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.hoc.2014.09.006","article-title":"A critical look at local-regional management of peritoneal metastasis","volume":"29","author":"Chan CH","year":"2015","journal-title":"Hematol Oncol Clin North Am"},{"issue":"2","key":"ref5","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1002\/(SICI)1097-0142(20000115)88:2<358::AID-CNCR16>3.0.CO;2-O","article-title":"Peritoneal carcinomatosis from non-gynecologic malignancies: results of the EVOCAPE 1 multicentric prospective study","volume":"88","author":"Sadeghi B","year":"2000","journal-title":"Cancer"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/978-1-4613-1247-5_6","article-title":"Observations concerning cancer spread within the peritoneal cavity and concepts supporting an ordered pathophysiology","volume":"82","author":"Sugarbaker PH","year":"1996","journal-title":"Cancer Treat Res"},{"issue":"5","key":"ref7","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1590\/0100-69912017005016","article-title":"A proposal of Brazilian Society of Surgical Oncology (BSSO\/SBCO) for standardizing cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) procedures in Brazil: pseudomixoma peritonei, appendiceal tumors and malignant peritoneal mesothelioma","volume":"44","author":"Batista TP","year":"2017","journal-title":"Rev Col Bras Cir"},{"issue":"5","key":"ref8","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S1470-2045(03)01074-X","article-title":"Intraperitoneal antineoplastic drug delivery: rationale and results","volume":"4","author":"Markman M","year":"2003","journal-title":"Lancet Oncol"},{"key":"ref9","first-page":"38","article-title":"In vitro evaluation of anticancer drugs against ovarian cancer at concentrations achievable by intraperitoneal administration","volume":"12","author":"Alberts DS","year":"1985","journal-title":"Semin Oncol"},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s004649900010","article-title":"Feasibility of therapeutic pneumoperitoneum in a large animal model using a microvaporisator","volume":"14","author":"Reymond MA","year":"2000","journal-title":"Surg Endosc"},{"issue":"1","key":"ref11","first-page":"49","article-title":"Current methodologies for clinical assessment of patients with peritoneal carcinomatosis","volume":"15","author":"Jacquet P","year":"1996","journal-title":"J Exp Clin Cancer Res"},{"issue":"6","key":"ref12","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1002\/bjs.10521","article-title":"Systematic review of pressurized intraperitoneal aerosol chemotherapy for the treatment of advanced peritoneal carcinomatosis","volume":"104","author":"Grass F","year":"2017","journal-title":"Br J Surg"},{"issue":"7","key":"ref13","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1245\/s10434-012-2840-2","article-title":"Renal and hepatic toxicities after pressurized intraperitoneal aerosol chemotherapy (PIPAC)","volume":"20","author":"Blanco A","year":"2013","journal-title":"Ann Surg Oncol"},{"issue":"2","key":"ref14","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.ygyno.2013.11.022","article-title":"Activity of Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) with cisplatin and doxorubicin in women with recurrent, platinum-resistant ovarian cancer: preliminary clinical experience","volume":"132","author":"Tempfer CB","year":"2014","journal-title":"Gynecol Oncol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/s12957-016-0892-7","article-title":"Safety and feasibility of pressurized intraperitoneal aerosol chemotherapy (PIPAC) associated with systemic chemotherapy an innovative approach to treat peritoneal carcinomatosis","volume":"14","author":"Robella M","year":"2016","journal-title":"World J Surg Oncol"},{"issue":"1","key":"ref16","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1007\/s00464-010-1065-3","article-title":"Can mathematic formulas help us with our patients?","volume":"25","author":"de Carvalho GL","year":"2011","journal-title":"Surg Endosc"},{"issue":"9","key":"ref17","doi-asserted-by":"crossref","first-page":"4595","DOI":"10.21873\/anticanres.11008","article-title":"Evaluating the effect of Micropump\u00a9 position, internal pressure and Doxorubicin dosage on efficacy of Pressurized Intra-peritoneal Aerosol Chemotherapy (PIPAC) in an ex vivo model","volume":"36","author":"Khosrawipour V","year":"2016","journal-title":"Anticancer Res"},{"issue":"2","key":"ref18","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s11605-015-2995-9","article-title":"Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) with low-dose Cisplatin and Doxorubicin in gastric peritoneal metastasis","volume":"20","author":"Nadiradze G","year":"2016","journal-title":"J Gastrointest Surg"},{"issue":"6","key":"ref19","first-page":"H2774","article-title":"In vivo hydraulic conductivity of muscle: effects of hydrostatic pressure","volume":"273","author":"Zakaria el-R","year":"1997","journal-title":"Am J Physiol"},{"issue":"2","key":"ref20","first-page":"H517","article-title":"In vivo effects of hydrostatic pressure on interstitium of abdominal wall muscle","volume":"276","author":"Zakaria ER","year":"1999","journal-title":"Am J Physiol"},{"issue":"4","key":"ref21","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1111\/codi.13130","article-title":"Pressurized intraperitoneal aerosol chemotherapy with oxaliplatin in colorectal peritoneal metastasis","volume":"18","author":"Demtr\u00f6der C","year":"2016","journal-title":"Colorectal Dis"},{"issue":"1","key":"ref22","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1186\/s12957-016-1008-0","article-title":"Pressurized intraperitoneal aerosol chemotherapy (PIPAC) as a neoadjuvant therapy before cytoreductive surgery and hyperthermic intraperitoneal chemotherapy","volume":"14","author":"Girshally R","year":"2016","journal-title":"World J Surg Oncol"},{"issue":"10","key":"ref23","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/j.ejso.2015.06.001","article-title":"Quality of life of patients with end-stage peritoneal metastasis treated with Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC)","volume":"41","author":"Odendahl K","year":"2015","journal-title":"Eur J Surg Oncol"}],"container-title":["Revista do Col\u00e9gio Brasileiro de Cirurgi\u00f5es"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/rcbc\/v45n4\/0100-6991-rcbc-45-04-e1909.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,9,5]],"date-time":"2018-09-05T15:09:46Z","timestamp":1536160186000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0100-69912018000400600&lng=pt&tlng=pt"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,20]]},"references-count":23,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2018]]}},"alternative-id":["S0100-69912018000400600"],"URL":"https:\/\/doi.org\/10.1590\/0100-6991e-20181909","relation":{},"ISSN":["1809-4546","0100-6991"],"issn-type":[{"value":"1809-4546","type":"electronic"},{"value":"0100-6991","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8,20]]}}}