{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:03:04Z","timestamp":1768867384096,"version":"3.49.0"},"reference-count":27,"publisher":"FapUNIFESP (SciELO)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Col. Bras. Cir."],"abstract":"<jats:p>RESUMO Objetivo: examinar os efeitos da sinvastatina na mucosite g\u00e1strica e intestinal ap\u00f3s o tratamento com 5-fluorouracil (5-FU), determinados pela express\u00e3o de citocinas e histologia em ratos. M\u00e9todos: ratos pesando 270\u00b115g foram divididos em dois grupos. O grupo 5-FU+salina foi tratado com 5-FU (50mg\/kg) mais solu\u00e7\u00e3o salina a 0,9% por gavagem uma vez ao dia por cinco dias. O grupo 5-FU+sinvastatina foi tratado com 5-FU (50mg\/kg), mais sinvastatina (10mg\/kg), da mesma forma. Foi feita a eutan\u00e1sia dos animais no sexto dia. O est\u00f4mago e o intestino foram fotografados e removidos para exame. Dosagens s\u00e9ricas de TNF-a, IL-1\u00df, IL-6 e histopatologia (colora\u00e7\u00e3o HE) do est\u00f4mago e intestino foram realizadas. Resultados: o peso corporal diminuiu em ratos no grupo 5-FU+salina. A sinvastatina n\u00e3o inibiu a perda de peso induzida pelo 5-FU. Danos significativos da mucosa no est\u00f4mago e no jejuno foram observados em ratos que receberam apenas 5-FU. As dosagens s\u00e9ricas de citocinas foram significativamente menores no grupo 5-FU+sinvastatina do que no grupo 5-FU (p&lt;0,05). A sinvastatina causou efeitos protetores significativos contra as les\u00f5es da mucosa g\u00e1strica e jejunal induzidas por 5-FU. Conclus\u00e3o: a sinvastatina atenua a mucosite g\u00e1strica e intestinal relacionada \u00e0 terap\u00eautica com 5-FU. Nossos dados encorajam futuros estudos pr\u00e9-cl\u00ednicos e cl\u00ednicos sobre a utilidade das estatinas na preven\u00e7\u00e3o da mucosite gastrointestinal.<\/jats:p>","DOI":"10.1590\/0100-6991e-20181968","type":"journal-article","created":{"date-parts":[[2018,10,19]],"date-time":"2018-10-19T15:14:51Z","timestamp":1539962091000},"source":"Crossref","is-referenced-by-count":12,"title":["Efeitos da sinvastatina na mucosite gastrointestinal induzida por 5-fluorouracil em ratos."],"prefix":"10.1590","volume":"45","author":[{"given":"Aldo da Cunha","family":"Medeiros","sequence":"first","affiliation":[{"name":"Universidade Federal do Rio Grande do Norte, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00cdtalo Medeiros","family":"Azevedo","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Norte, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00edlia Leite","family":"Lima","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Norte, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irami","family":"Ara\u00fajo Filho","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Norte, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00edlia Daniela","family":"Moreira","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Norte, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2018,10,18]]},"reference":[{"issue":"5","key":"ref1","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1002\/cncr.22484","article-title":"Updated clinical practice guidelines for the prevention and treatment of mucositis","volume":"109","author":"Keefe 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