{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T19:03:21Z","timestamp":1767035001617,"version":"3.41.2"},"reference-count":21,"publisher":"FapUNIFESP (SciELO)","issue":"6","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Col. Bras. Cir."],"abstract":"<jats:p>RESUMO  Objetivo: descrever os achados histol\u00f3gicos das ves\u00edculas biliares de pacientes submetidos \u00e0 colecistectomia e avaliar a presen\u00e7a de fatores associados ao c\u00e2ncer incidental da ves\u00edcula.  M\u00e9todos: estudo descritivo, transversal e observacional de 1.278 exames anatomopatol\u00f3gicos de ves\u00edculas biliares oriundas de colecistectomias por colelit\u00edase e de seus respectivos laudos, realizadas no per\u00edodo de janeiro de 2008 a dezembro de 2017.  Resultados: o achado anatomopatol\u00f3gico mais frequente foi a colecistite cr\u00f4nica, presente em 1.251 pacientes (97,8%), seguido pela colesterolose em 131 (10,2%). O c\u00e2ncer de ves\u00edcula foi identificado em seis pacientes, com preval\u00eancia de 0,5% nesta amostra. Houve associa\u00e7\u00e3o significativa entre a presen\u00e7a de c\u00e2ncer e idade \u226560 anos e com a espessura da parede \u22650,3cm.  Conclus\u00e3o: houve baixa preval\u00eancia de c\u00e2ncer de ves\u00edcula na popula\u00e7\u00e3o avaliada, maior ocorr\u00eancia na popula\u00e7\u00e3o idosa e associa\u00e7\u00e3o de tumor com espessamento da parede vesicular.<\/jats:p>","DOI":"10.1590\/0100-6991e-20192279","type":"journal-article","created":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T09:51:05Z","timestamp":1579600265000},"source":"Crossref","is-referenced-by-count":5,"title":["Altera\u00e7\u00f5es histol\u00f3gicas da ves\u00edcula biliar de doentes submetidos \u00e0 colecistectomia por colelit\u00edase"],"prefix":"10.1590","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3217-6997","authenticated-orcid":false,"given":"Ana Karolina Gama","family":"Holanda","sequence":"first","affiliation":[{"name":"Universidade Federal da Para\u00edba (UFPB),  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zailton Bezerra","family":"Lima J\u00fanior","sequence":"additional","affiliation":[{"name":"Universidade Federal da Para\u00edba (UFPB),  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2019]]},"reference":[{"issue":"2","key":"ref1","doi-asserted-by":"crossref","first-page":"172","DOI":"10.5009\/gnl.2012.6.2.172","article-title":"Epidemiology of gallbladder disease: cholelithiasis and cancer","volume":"6","author":"Stinton LM","year":"2012","journal-title":"Gut Liver"},{"issue":"6","key":"ref2","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1111\/j.1572-0241.2000.02070.x","article-title":"Primary gallbladder c\u00e2ncer: recognition of risk factors and the role of prophylactic cholecystectomy","volume":"95","author":"Sheth S","year":"2000","journal-title":"Am J Gastroenterol"},{"issue":"8","key":"ref3","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1007\/s00535-007-2072-6","article-title":"Simultaneous presence of xanthogranulomatous cholecystitis and gallbladder cancer","volume":"42","author":"Kwon AH","year":"2007","journal-title":"J Gastroenterol"},{"issue":"6","key":"ref4","first-page":"673","article-title":"P\u00f3lipos y adenomas de la ves\u00edcula biliar: consideraciones cl\u00ednico-patol\u00f3gicas","volume":"132","author":"Roa EI","year":"2004","journal-title":"Rev Med Chile"},{"issue":"7","key":"ref5","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1002\/ijc.21683","article-title":"Gallbladder cancer worldwide: geographical distribution and risk factors","volume":"118","author":"Randi G","year":"2006","journal-title":"Int J Cancer"},{"issue":"6","key":"ref6","doi-asserted-by":"crossref","first-page":"349","DOI":"10.3322\/canjclin.51.6.349","article-title":"Epidemiology and molecular pathology of gallbladder cancer","volume":"51","author":"Lazcano-Ponce EC","year":"2001","journal-title":"CA Cancer J Clin"},{"key":"ref7","first-page":"99","article-title":"Gallbladder c\u00e2ncer: epidemiology and outcome","volume":"6","author":"Hundal R","year":"2014","journal-title":"Clin Epidemiol"},{"series-title":"Procedimentos hospitalares do SUS por local de interna\u00e7\u00e3o - 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