{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:17:28Z","timestamp":1787023048607,"version":"build-2736575974"},"reference-count":25,"publisher":"FapUNIFESP (SciELO)","issue":"5","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Col. Bras. Cir."],"abstract":"<jats:p>RESUMO  Objetivo: avaliar a efic\u00e1cia do extrato de Baccharis dracunculifolia no tratamento de f\u00edstulas anais em ratos.  M\u00e9todos: vinte ratos Wistar machos foram submetidos \u00e0 confec\u00e7\u00e3o de f\u00edstula anal e, ap\u00f3s 30 dias, foram distribu\u00eddos em tr\u00eas grupos: Grupo Controle, com cinco animais; Grupo Carbopol, com cinco animais; e Grupo Baccharis dracunculifolia, com dez animais. No Grupo Controle, n\u00e3o se realizou nenhum tratamento. No Grupo Carbopol, realizou-se infus\u00e3o di\u00e1ria de carbopol, e no Grupo Baccharis dracunculifolia, infus\u00e3o de extrato de Baccharis dracunculifolia com carbopol, ambos por 30 dias. Foram retirados esp\u00e9cimes para an\u00e1lise histol\u00f3gica ap\u00f3s a eutan\u00e1sia.  Resultados: n\u00e3o houve fechamento completo do trajeto fistuloso em nenhum dos animais. A m\u00e9dia da \u00e1rea do trajeto resultante foi de 847,2\u00b5m2, 565,6\u00b5m2 e 372,7\u00b5m2, respectivamente, nos Grupos Controle, Carbopol e Baccharis dracunculifolia (p=0,001). A m\u00e9dia do escore de processo inflamat\u00f3rio foi de 2,4, 2,4 e 2,1, respectivamente, nos Grupos Controle, Carbopol e Baccharis dracunculifolia (p=0,285), enquanto a m\u00e9dia de congest\u00e3o vascular foi de 1,6, 1,4 e 1,1, respectivamente, nos Grupos Controle, Carbopol e Baccharis dracunculifolia (p=0,031).  Conclus\u00e3o: o extrato de Baccharis dracunculifolia foi capaz de reduzir o l\u00famen dos trajetos fistulosos e a congest\u00e3o vascular, sem reduzir, no entanto, o processo inflamat\u00f3rio local ou fechar totalmente os trajetos fistulosos.<\/jats:p>","DOI":"10.1590\/0100-6991e-20192297","type":"journal-article","created":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T04:48:20Z","timestamp":1579582100000},"source":"Crossref","is-referenced-by-count":2,"title":["Tratamento da f\u00edstula anal com extrato de Baccharis dracunculifolia. Estudo experimental em ratos."],"prefix":"10.1590","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1181-7329","authenticated-orcid":false,"given":"Carlos Henrique Marques dos","family":"Santos","sequence":"first","affiliation":[{"name":"Universidade Anhanguera (Uniderp),  Brasil; Universidade Federal de Mato Grosso do Sul,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Lu\u00eds","family":"Cavasana","sequence":"additional","affiliation":[{"name":"Universidade Anhanguera (Uniderp),  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davyson de Lima","family":"Moreira","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doroty Mesquita","family":"Dourado","sequence":"additional","affiliation":[{"name":"Universidade Anhanguera (Uniderp),  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe 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