{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T18:29:04Z","timestamp":1793730544462,"version":"4.6.1"},"reference-count":20,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Col. Bras. Cir."],"abstract":"<jats:p>ABSTRACT  Introduction:  to evaluate the effect of short-course (i.e.: 30 minutes) HIPEC on health-related quality of life (HRQoL) in our feasibility study; NCT02249013.  Methods:  a prespecified secondary end-point of our open-label, multicenter, single-arm, phase 2 trial on safety and efficacy was assessed using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30, version 3.0). Patients were required to complete the HRQoL questionnaire at baseline, after HIPEC, and after the end of the treatment. Changes of HRQoL over time were assessed by median scores for each domain and analyzed by Friedman`s test at a significant two-sided level of 0.05.  Results:  fifteen patients with high tumor burden EOC were recruited from our public health system between February 2015 and July 2019. A baseline EORTC QLQ-C30 questionnaire and at least one follow-up questionnaire was received from all of the patients. No significant difference over time in the QLQC30 summary scores was observed (p&gt;0.05). The transitory impairment on patients HRQoL immediately after the short-course HIPEC trended to return to baseline at the end of the multimodal treatment.  Conclusions:  we found no significant impairment of short-course HIPEC on patients HRQoL into the context of our comprehensive treatment protocol.<\/jats:p>","DOI":"10.1590\/0100-6991e-20202534","type":"journal-article","created":{"date-parts":[[2020,7,12]],"date-time":"2020-07-12T16:51:24Z","timestamp":1594572684000},"source":"Crossref","is-referenced-by-count":4,"title":["Quality of life in a phase 2 trial of short-course hyperthermic intraperitoneal chemotherapy (HIPEC) at interval debulking surgery for high tumor burden ovarian cancer"],"prefix":"10.1590","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2265-1368","authenticated-orcid":false,"given":"ROBERTO JOS\u00c9 COSTA","family":"LUSTOSA","sequence":"first","affiliation":[{"name":"Instituto de Medicina Integral Professor Fernando Figueira,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"THALES PAULO","family":"BATISTA","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Integral Professor Fernando Figueira,  Brazil; Universidade Federal de Pernambuco,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"VANDR\u00c9 CABRAL GOMES","family":"CARNEIRO","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Integral Professor Fernando Figueira,  Brazil; Hospital de C\u00e2ncer de Pernambuco,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LEVON","family":"BADIGLIAN-FILHO","sequence":"additional","affiliation":[{"name":"AC Camargo Cancer Center,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RONALDO L\u00daCIO RANGEL","family":"COSTA","sequence":"additional","affiliation":[{"name":"Instituto Brasileiro de Controle do C\u00e2ncer,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ANDR\u00c9","family":"LOPES","sequence":"additional","affiliation":[{"name":"Instituto Brasileiro de Controle do C\u00e2ncer,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BRUNO JOS\u00c9 DE QUEIROZ","family":"SARMENTO","sequence":"additional","affiliation":[{"name":"Instituto Hospital de Base do Distrito Federal,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JUREMA TELLES DE OLIVEIRA","family":"LIMA","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Integral Professor Fernando Figueira,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MARIA JULIA GON\u00c7ALVES DE","family":"MELLO","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Integral Professor Fernando Figueira,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CRISTIANO SOUZA","family":"LE\u00c3O","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Integral Professor Fernando Figueira,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2020]]},"reference":[{"issue":"27","key":"ref1","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1200\/JCO.19.00671","article-title":"Role of Intraperitoneal Therapy in the Initial Management of Ovarian Cancer","volume":"37","author":"Armstrong DK","year":"2019","journal-title":"J Clin Oncol"},{"issue":"26","key":"ref2","doi-asserted-by":"crossref","first-page":"2841","DOI":"10.1200\/JCO.2015.61.4776","article-title":"Use and Effectiveness of Intraperitoneal Chemotherapy for Treatment of Ovarian Cancer","volume":"33","author":"Wright AA","year":"2015","journal-title":"J Clin Oncol"},{"issue":"1","key":"ref3","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.ygyno.2005.11.013","article-title":"Intraperitoneal catheter outcomes in a phase III trial of intravenous versus intraperitoneal chemotherapy in optimal stage III ovarian and primary peritoneal 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