{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T05:56:19Z","timestamp":1757310979337,"version":"3.41.2"},"reference-count":26,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Col. Bras. Cir."],"abstract":"<jats:p>ABSTRACT  Objective:  the hernial sac is typically a bilayer structure consisting of connective tissue lined underneath by peritoneum. Some incidental findings on it, like smooth muscle cells and heterotopic ossification, can be explained as the end-stage metaplasia from undifferentiated cells. This study aimed to search for mesenchymal stem cells in the incisional hernial sac by an immuno-histochemistry screening test.  Methods:  fifteen specimens of them were submitted to histochemistry analysis using CD133 monoclonal antibodies, a specific marker of mesenchymal stem cells. The biopsies were obtained from patients submitted to pure tissue repair for incisional hernias - the transposition with the hernial sac technique (L\u00e1zaro da Silva, 1971).  Results:  two-thirds of the specimens expressed on average 20 (twenty) CD133+ cells in each one.  Conclusion:  despite the screening nature of this study, the hernial sac may be considered a source of stem cells. This could explain those abnormal findings, and perhaps the induction of new fibroblasts in procedures that use it to optimize wound healing.<\/jats:p>","DOI":"10.1590\/0100-6991e-20202636","type":"journal-article","created":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T19:10:10Z","timestamp":1604689810000},"source":"Crossref","is-referenced-by-count":2,"title":["Tracking stem cells in the incisional hernial sac: a gaze beyond pure tissue repairs"],"prefix":"10.1590","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5230-2789","authenticated-orcid":false,"given":"RENATO MIRANDA DE","family":"MELO","sequence":"first","affiliation":[{"name":"Universidade Federal de Goi\u00e1s,  Brazil; Santa Casa de Miseric\u00f3rdia de Goi\u00e2nia,  Brazil; Hospital Geral de Goi\u00e2nia \u201cDr. Alberto Rassi\u201d,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1181-2373","authenticated-orcid":false,"given":"ROBERPAULO ANACLETO","family":"NEVES","sequence":"additional","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica de Goi\u00e1s,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4237-6279","authenticated-orcid":false,"given":"LILIANA BORGES DE","family":"MENEZES","sequence":"additional","affiliation":[{"name":"Universidade Federal de Goi\u00e1s,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2020]]},"reference":[{"issue":"6","key":"ref1","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1177\/039139880703000608","article-title":"The use of peritoneal mesothelium as a potential source of adult stem cells","volume":"30","author":"Gotloib L","year":"2007","journal-title":"Int J Artif Organs"},{"issue":"1","key":"ref2","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s10029-014-1288-7","article-title":"The future of stem cell therapy in hernia 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new technique of \"Marlex peritoneal sandwich\" in the repair of large incisional hernias [letter] World","volume":"17","author":"Guarnieri A","year":"1993","journal-title":"J Surg"},{"issue":"1","key":"ref26","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s12893-019-0523-7","article-title":"Abdominal skin tensile strength in aesthetic and massive weight loss patients and its role in ventral hernia repair","volume":"19","author":"Barreiro G","year":"2019","journal-title":"BMC Surg"}],"container-title":["Revista do Col\u00e9gio Brasileiro de 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