{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:17:30Z","timestamp":1787023050211,"version":"build-2736575974"},"reference-count":23,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Col. Bras. Cir."],"abstract":"<jats:p>ABSTRACT  Introduction:  although it is a rare disease, common variable immunodeficiency (CVID) stands out as the most frequent primary symptomatic immunodeficiency. Carriers are prone to a variety of recurrent bacterial infections, in addition to the risk of developing autoimmune diseases and neoplasms including gastric cancer (GC). Despite the recognized risk, there are no specific standardized protocols for the management of GC in these patients, so the reported oncological results are varied. Thus, this study aims to describe the clinicopathological characteristics and prognosis of patients with CVID undergoing surgical treatment of GC.  Methods:  all patients with GC undergoing surgical treatment between 2009 and 2020 were retrospectively evaluated. Later, patients diagnosed with CVID were identified and this group was compared with the remaining patients without any immunodeficiency.  Results:  among the 1101 patients with GC evaluated in the period, 10 had some type of immunodeficiency, and 5 were diagnosed with CVID. Patients with CVID had younger age, lower BMI, and smaller lesions compared to those without CVID. Four patients underwent curative gastrectomy and one patient underwent jejunostomy. Two patients died (1 palliative and 1 curative) and one patient had disease recurrence. There was no statistically significant difference regarding the incidence of postoperative complications and survival between the evaluated groups.  Conclusion:  the CVID incidence in patients with GC undergoing surgical treatment was 0.5%, occurring at a less advanced age, but with no difference regarding surgical and oncological results.<\/jats:p>","DOI":"10.1590\/0100-6991e-20213133","type":"journal-article","created":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T08:12:22Z","timestamp":1639555942000},"source":"Crossref","is-referenced-by-count":4,"title":["Common variable immunodeficiency: an important but little-known risk factor for gastric cancer"],"prefix":"10.1590","volume":"48","author":[{"given":"PAULA","family":"KREIN","sequence":"first","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GUSTAVO GON\u00c7ALVES","family":"YOGOLARE","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MARINA ALESSANDRA","family":"PEREIRA","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"OCTAVIO","family":"GRECCO","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MYRTHES ANNA MARAGNA TOLEDO","family":"BARROS","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ANDRE RONCON","family":"DIAS","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ANA KAROLINA BARRETO BERSELLI","family":"MARINHO","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BRUNO","family":"ZILBERSTEIN","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CRISTINA MARIA","family":"KOKRON","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ULYSSES","family":"RIBEIRO-J\u00daNIOR","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JORGE","family":"KALIL","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SERGIO CARLOS","family":"NAHAS","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0200-7858","authenticated-orcid":false,"given":"MARCUS FERNANDO KODAMA PERTILLE","family":"RAMOS","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2021]]},"reference":[{"issue":"6","key":"ref1","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray F","year":"2018","journal-title":"CA Cancer J Clin"},{"key":"ref2","series-title":"INCA INdCJAGdS, ed","volume-title":"Estimativa 2020: incid\u00eancia de c\u00e2ncer no Brasil","year":"2019"},{"issue":"7","key":"ref3","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1590\/1806-9282.64.07.611","article-title":"Risk factors associated with the development of gastric cancer - case-control study","volume":"64","author":"Ramos M","year":"2018","journal-title":"Rev Assoc Med Bras (1992)"},{"issue":"6","key":"ref4","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s11894-002-0022-2","article-title":"Gastric neoplasia","volume":"4","author":"Correa P","year":"2002","journal-title":"Curr Gastroenterol Rep"},{"issue":"24","key":"ref5","first-page":"6735","article-title":"Human gastric carcinogenesis a multistep and multifactorial process--First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention","volume":"52","author":"Correa P","year":"1992","journal-title":"Cancer Res"},{"key":"ref6","series-title":"WHO Classification of Tumours of the Digestive System. 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