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Sa\u00fade P\u00fablica"],"abstract":"<jats:p>Resumo: A vacina\u00e7\u00e3o \u00e9 uma das maiores interven\u00e7\u00f5es em sa\u00fade p\u00fablica pela seguran\u00e7a e efetividade, por\u00e9m nem sempre vacinar significa imunizar. In\u00fameros aspectos relacionados tanto ao indiv\u00edduo que recebe a vacina, quanto \u00e0 especificidade de cada imunobiol\u00f3gico administrado comp\u00f5em o processo para a obten\u00e7\u00e3o de uma adequada imuniza\u00e7\u00e3o, sendo essencial que sejam observados para n\u00e3o culminar em falhas vacinais. A an\u00e1lise dos estudos de imunogenicidade e efetividade para as vacinas sarampo, varicela e caxumba apontam para a necessidade da incorpora\u00e7\u00e3o de duas doses aos calend\u00e1rios b\u00e1sicos de vacina\u00e7\u00e3o para o controle das referidas doen\u00e7as. Estudos epidemiol\u00f3gicos que analisaram surtos dessas doen\u00e7as identificaram casos em indiv\u00edduos que receberam duas doses da vacina, o que pode apontar prov\u00e1vel falha secund\u00e1ria. Para a vacina febre amarela, a discuss\u00e3o atual reside no n\u00famero de doses ideal para a prote\u00e7\u00e3o individual. A Organiza\u00e7\u00e3o Mundial da Sa\u00fade recomenda dose \u00fanica para toda a vida. Apesar dos poucos relatos em literatura a respeito das falhas vacinais, os estudos de imunogenicidade demonstram perda de prote\u00e7\u00e3o ao longo dos anos, principalmente na faixa et\u00e1ria pedi\u00e1trica. Num cen\u00e1rio atual de elimina\u00e7\u00e3o e controle de doen\u00e7as, associado \u00e0 diminui\u00e7\u00e3o da circula\u00e7\u00e3o de v\u00edrus selvagens, o papel da vigil\u00e2ncia epidemiol\u00f3gica \u00e9 fundamental para aprofundar o conhecimento a respeito dos m\u00faltiplos fatores envolvidos, que culminam com falhas vacinais e surgimento de surtos. A ocorr\u00eancia de surtos de doen\u00e7as imunopreven\u00edveis impacta negativamente a credibilidade dos programas de imuniza\u00e7\u00e3o, acarretando baixas coberturas vacinais e interferindo no \u00eaxito da vacina\u00e7\u00e3o.<\/jats:p>","DOI":"10.1590\/0102-311x00008520","type":"journal-article","created":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T17:52:57Z","timestamp":1604425977000},"source":"Crossref","is-referenced-by-count":4,"title":["Falhas vacinais: avaliando vacinas febre amarela, sarampo, varicela e caxumba"],"prefix":"10.1590","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8083-3509","authenticated-orcid":false,"given":"T\u00e2nia Cristina de Mattos Barros","family":"Petraglia","sequence":"first","affiliation":[{"name":"Universidade Est\u00e1cio de S\u00e1,  Brazil; Hospital Municipal Rocha Maia,  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