{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:02:27Z","timestamp":1753887747882,"version":"3.41.2"},"reference-count":34,"publisher":"FapUNIFESP (SciELO)","issue":"3","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cad. Sa\u00fade P\u00fablica"],"abstract":"<jats:p>Abstract: The objectives of this study were to analyze in-hospital adverse drug events (ADEs) in Portuguese public hospitals, and their association with mortality and the duration of hospitalization. We analyzed an administrative database containing the registration of all hospitalizations occurring in Portuguese public hospitals in 2013-2015. ADEs were identified using the codes E850-858.9 and E930-949.9 from ICD-9-CM. We identified all episodes with registration of in-hospital ADE and we compared them with a random sample of an equal number of episodes with no events recorded. A total of 3,041,443 cases were analyzed, 60,521 presented at least one ADE from which 17,213 occurred in hospital context. The most frequent drug classes associated with ADE were the antineoplastics\/immunosuppressant drugs, antibiotics and steroids. Patient characteristics associated with a greater occurrence of in-hospital ADEs (all with p &lt; 0.001) were medical admissions (OR = 1.29), the diagnosis - myeloid leukaemia (OR = 18.63), nephrotic syndrome (OR = 15.75), pneumonia (OR = 1.33) -, a higher number of secondary diagnoses (OR = 1.27), and increased duration of hospital stay (OR = 1.06). Hospitalizations with records of in-hospital ADEs presented a significantly higher mortality (9.6% vs. 4.5) and duration of hospitalization (22.6 vs. 6.4 days). ADEs were shown to be directly associated with an increase in the duration of hospital stay of 8.18 days. This study adds some interesting insights related to the most frequent drug classes and patient characteristics that can influence the frequency of ADEs in Portuguese public hospitals and also the burden of injury resulting from them.<\/jats:p>","DOI":"10.1590\/0102-311x00056519","type":"journal-article","created":{"date-parts":[[2020,3,13]],"date-time":"2020-03-13T12:48:45Z","timestamp":1584103725000},"source":"Crossref","is-referenced-by-count":5,"title":["In-hospital adverse drug events: analysis of trend in Portuguese public hospitals"],"prefix":"10.1590","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9238-3261","authenticated-orcid":false,"given":"Mavilde","family":"Vitorino","sequence":"first","affiliation":[{"name":"Centro Hospitalar Lisboa Ocidenta,  Portugal; Universidade Nova de Lisboa,  Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0074-7732","authenticated-orcid":false,"given":"Pedro","family":"Aguiar","sequence":"additional","affiliation":[{"name":"Universidade Nova de Lisboa,  Portugal; Centro de Investiga\u00e7\u00e3o em Sa\u00fade P\u00fablica,  Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9502-6075","authenticated-orcid":false,"given":"Paulo","family":"Sousa","sequence":"additional","affiliation":[{"name":"Universidade Nova de Lisboa,  Portugal; Centro de Investiga\u00e7\u00e3o em Sa\u00fade P\u00fablica,  Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2020]]},"reference":[{"year":"2009","series-title":"Conceptual framework for the international classification for patient safety: version 1.1","key":"ref1"},{"series-title":"Planning for the global patient safety challenge on medication safety","key":"ref2"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1007\/s00228-017-2330-3","article-title":"The prevalence of medication-related adverse events in inpatients a systematic review and meta-analysis","volume":"73","author":"Laatikainen O","year":"2017","journal-title":"Eur J Clin Pharmacol"},{"key":"ref4","doi-asserted-by":"crossref","DOI":"10.1111\/ijcp.12990","article-title":"Association of preventable adverse drug events with inpatients' length of stay a propensity-matched cohort study","volume":"71","author":"Amelung S","year":"2017","journal-title":"Int J Clin Pract"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1002\/pds.4184","article-title":"Burden of hospitalizations related to adverse drug events in the USA a retrospective analysis from large inpatient database","volume":"26","author":"Poudel DR","year":"2017","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1111\/jcpt.12204","article-title":"Adverse drug events among adult inpatients a meta-analysis of observational studies","volume":"39","author":"Martins ACM","year":"2014","journal-title":"J Clin Pharm Ther"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1071\/AH13166","article-title":"Exploring in-hospital adverse drug events using ICD-10 codes","volume":"38","author":"Parikh S","year":"2014","journal-title":"Aust Health Rev"},{"year":"2018","series-title":"Characteristics of adverse drug events originating during the hospital stay, 2011: statistical brief #164","author":"Weiss AJ","key":"ref8"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1093\/intqhc\/mzx190","article-title":"Patient and hospital characteristics that influence incidence of adverse events in acute public hospitals in Portugal a retrospective cohort study","volume":"30","author":"Sousa P","year":"2018","journal-title":"Int J Qual Health Care"},{"key":"ref10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0178626","article-title":"Adverse drug events analysis of a decade. 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