{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T13:54:28Z","timestamp":1790862868682,"version":"4.1.0"},"reference-count":80,"publisher":"FapUNIFESP (SciELO)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cad. Sa\u00fade P\u00fablica"],"abstract":"<jats:p>Em agosto de 2015, neuropediatras de hospitais p\u00fablicos do Recife, Pernambuco, Brasil, observaram um aumento do n\u00famero de casos de microcefalia desproporcional associado a anomalias cerebrais. Esse fato gerou como\u00e7\u00e3o social, mobiliza\u00e7\u00e3o da comunidade acad\u00eamica e levou o Minist\u00e9rio da Sa\u00fade a decretar emerg\u00eancia de sa\u00fade p\u00fablica nacional, seguida pela declara\u00e7\u00e3o de emerg\u00eancia de sa\u00fade p\u00fablica de interesse internacional da Organiza\u00e7\u00e3o Mundial da Sa\u00fade. A hip\u00f3tese formulada para o fen\u00f4meno foi a infec\u00e7\u00e3o cong\u00eanita pelo v\u00edrus Zika (ZIKV), com base na correla\u00e7\u00e3o espa\u00e7o-temporal e nas caracter\u00edsticas cl\u00ednico-epidemiol\u00f3gicas das duas epidemias. Evid\u00eancias se acumularam e no \u00e2mbito do racioc\u00ednio epidemiol\u00f3gico preencheram crit\u00e9rios que deram sustenta\u00e7\u00e3o \u00e0 hip\u00f3tese. Sua plausibilidade est\u00e1 ancorada no neurotropismo do ZIKV demonstrado em animais, atingindo neur\u00f4nios progenitores do c\u00e9rebro em desenvolvimento, e em seres humanos devido \u00e0s complica\u00e7\u00f5es neurol\u00f3gicas observadas em adultos ap\u00f3s a infec\u00e7\u00e3o. O isolamento do RNA e ant\u00edgenos virais no l\u00edquido amni\u00f3tico de m\u00e3es infectadas e em c\u00e9rebros de neonatos e fetos com microcefalia contribu\u00edram para demonstrar a consist\u00eancia da hip\u00f3tese. O crit\u00e9rio de temporalidade foi contemplado ao se identificar desfechos desfavor\u00e1veis em uma coorte de gestantes com exantema e positivas para o ZIKV. Finalmente, o primeiro estudo caso-controle conduzido demonstrou existir uma forte associa\u00e7\u00e3o entre microcefalia e infec\u00e7\u00e3o cong\u00eanita pelo ZIKV. O conhecimento constru\u00eddo no \u00e2mbito do paradigma epidemiol\u00f3gico recebeu a chancela da comunidade cient\u00edfica, construindo o consenso de uma rela\u00e7\u00e3o causal entre o ZIKV e a epidemia de microcefalia.<\/jats:p>","DOI":"10.1590\/0102-311x00069018","type":"journal-article","created":{"date-parts":[[2018,10,10]],"date-time":"2018-10-10T20:47:36Z","timestamp":1539204456000},"source":"Crossref","is-referenced-by-count":30,"title":["Epidemia de microcefalia e v\u00edrus Zika: a constru\u00e7\u00e3o do conhecimento em epidemiologia"],"prefix":"10.1590","volume":"34","author":[{"given":"Maria de Fatima Pessoa Milit\u00e3o de","family":"Albuquerque","sequence":"first","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayner Vieira de","family":"Souza","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thalia Velho Barreto","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pernambuco,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Cynthia","family":"Braga","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dem\u00f3crito de Barros","family":"Miranda Filho","sequence":"additional","affiliation":[{"name":"Universidade de Pernambuco,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo Arraes de Alencar","family":"Ximenes","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pernambuco,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Djalma Agripino","family":"de Melo Filho","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pernambuco,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Alexandre Antunes de","family":"Brito","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pernambuco,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Valongueiro","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pernambuco,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula Lopes de","family":"Melo","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pernambuco,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinval Pinto","family":"Brand\u00e3o- Filho","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celina Maria Turchi","family":"Martelli","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2018,10,11]]},"reference":[{"key":"ref1","series-title":"Nota Informativa n\u00ba 01\/2015 - COES microcefalias. 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