{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:02:21Z","timestamp":1790838141513,"version":"4.1.0"},"reference-count":115,"publisher":"FapUNIFESP (SciELO)","issue":"2","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cad. Sa\u00fade P\u00fablica"],"abstract":"<jats:p>Mercury is a metal found in the environment from natural and anthropogenic sources. It is highly toxic to ecosystems and living beings. Most human exposures come from ingestion of contaminated seafood, outgassing from dental amalgam or occupational exposure (e.g. gold mining), among other cases. Large populations are exposed to mercury, making it a very important issue from the public health perspective. Adverse health effects are commonly seen in the nervous system, but every organ is a potential target, such as the bone marrow. The main goal of this study was to assess the available evidence on human exposure to mercury and its hematological effects. A search strategy was constructed, including key terms (MeSH, text word and equivalents) for querying 2 repositories of master dissertation and PhD thesis (Fiocruz\/ARCA and University of S\u00e3o Paulo) and 4 different electronic databases: BVS\/LILACS, MEDLINE\/PubMed, Scopus and TOXLINE\/NIH, for articles published from 1950 to February 2018. There was no language restriction and a tool (EPHPP) was used to assess the quality of included studies. According to pre-established criteria, 80 studies were retrieved, all of them observational (48 case reports, 24 cross-sectional, 6 case series and 2 cohorts), comprising 9,284 people. Despite the fact that most exposed ones (6,012) had normal blood cell count and mercury hematological effects did not seem very usual (1,914 cases: 14 severe and 29 deaths), three studies reported association (\u03b2) for anemia, lymphopenia, neutrophilia and basophilia. We concluded that the gathered information pointed to mercury hematotoxic effects, some of them may be serious and even fatal.<\/jats:p>","DOI":"10.1590\/0102-311x00091618","type":"journal-article","created":{"date-parts":[[2019,2,9]],"date-time":"2019-02-09T18:25:51Z","timestamp":1549736751000},"source":"Crossref","is-referenced-by-count":52,"title":["Human exposure to mercury and its hematological effects: a systematic review"],"prefix":"10.1590","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0657-2141","authenticated-orcid":false,"given":"Ang\u00e9lica dos Santos","family":"Vianna","sequence":"first","affiliation":[{"name":"Universidade Federal do Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4027-6058","authenticated-orcid":false,"given":"Elisabete Pedra de","family":"Matos","sequence":"additional","affiliation":[{"name":"Pesquisadora Independente, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9828-3720","authenticated-orcid":false,"given":"Iracina Maura de","family":"Jesus","sequence":"additional","affiliation":[{"name":"Instituto Evandro Chagas, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9864-6656","authenticated-orcid":false,"given":"Carmen Ildes Rodrigues Fr\u00f3es","family":"Asmus","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro, Brazil; Universidade Federal do Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6596-6653","authenticated-orcid":false,"given":"Volney de Magalh\u00e3es","family":"C\u00e2mara","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro, Brazil; Universidade Federal do Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2019]]},"reference":[{"key":"ref1","first-page":"26","article-title":"Intoxicaci\u00f3n acidental con merc\u00fario elemental","volume":"30","author":"Contreras C","year":"2017","journal-title":"Acta Med Per"},{"key":"ref2","series-title":"The global mercury modelling: update of modelling results in the Global Mercury Assessment 2013","year":"2015"},{"key":"ref3","first-page":"133","article-title":"Heavy metals toxicity and the environment","volume":"101","author":"Tchounwou PB","year":"2012","journal-title":"EXS"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1289\/ehp.02110s111","article-title":"The three modern faces of mercury","volume":"110","author":"Clarkson TW","year":"2002","journal-title":"Environ Health Perspect"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"6905","DOI":"10.1002\/chem.201704840","article-title":"The mercury 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