{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T22:05:50Z","timestamp":1761948350043},"reference-count":20,"publisher":"FapUNIFESP (SciELO)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cad. Sa\u00fade P\u00fablica"],"abstract":"<jats:p>Abstract: The aim of the present study was to estimate the financial costs of the incorporation and\/or replacement of diagnostic tests for human visceral leishmaniasis (VL) in Brazil. The analysis was conducted from the perspective of the Brazilian Unified National Health System (SUS) over a period of three years. Six diagnostic tests were evaluated: the indirect immunofluorescence antibody test (IFAT), the IT LEISH rapid test, the parasitological examination of bone marrow aspirate, the direct agglutination test (DAT-LPC) standardized in the Clinical Research Laboratory, Ren\u00e9 Rachou Institute of the Oswaldo Cruz Foundation, the Kalazar Detect rapid test, and polymerase chain reaction (PCR). The assumptions used were the number of suspected cases of VL reported to the Brazilian Ministry of Health in 2014 and the direct cost of diagnostic tests. The costs to diagnose suspected cases of VL over three years using the IFAT and the DAT-LPC were estimated at USD 280,979.91 and USD 121,371.48, respectively. The analysis indicated that compared with the use of the IFAT, the incorporation of the DAT-LPC into the SUS would result in savings of USD 159,608.43. With regard to the budgetary impact of rapid tests, the use of IT LEISH resulted in savings of USD 21.708,72 over three years. Compared with a parasitological examination, diagnosis using PCR resulted in savings of USD 3,125,068.92 over three years. In this study, the replacement of the IFAT with the DAT-LPC proved financially advantageous. In addition, the replacement of the Kalazar Detect rapid test with the IT LEISH in 2015 was economically valuable, and the replacement of parasitological examination with PCR was indicated.<\/jats:p>","DOI":"10.1590\/0102-311x00142416","type":"journal-article","created":{"date-parts":[[2017,12,16]],"date-time":"2017-12-16T22:44:31Z","timestamp":1513464271000},"source":"Crossref","is-referenced-by-count":3,"title":["Budgetary impact of diagnostic tests for visceral leishmaniasis in Brazil"],"prefix":"10.1590","volume":"33","author":[{"given":"T\u00e1lia Santana Machado de","family":"Assis","sequence":"first","affiliation":[{"name":"Centro Federal de Educa\u00e7\u00e3o Tecnol\u00f3gica de Minas Gerais,  Brazil; Funda\u00e7\u00e3o Oswaldo Cruz,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9 Lu\u00eds Ferreira de","family":"Azeredo-da-Silva","sequence":"additional","affiliation":[{"name":"Instituto para Avalia\u00e7\u00e3o de Tecnologias em Sa\u00fade,  Brasil; Universidade Federal do Rio Grande do Sul,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gl\u00e1ucia","family":"Cota","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guilherme Loureiro","family":"Werneck","sequence":"additional","affiliation":[{"name":"Universidade do Estado do Rio de Janeiro,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Rabello","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2017,12,18]]},"reference":[{"key":"ref1","series-title":"Investing to overcome the global impact of neglected tropical diseases"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.trstmh.2007.11.004","article-title":"Comparative evaluation of direct agglutination test, rK39 and soluble antigen ELISA and IFATT for the diagnosis of visceral leishmaniasis","volume":"102","author":"Pedras MJ","year":"2008","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1111\/j.1365-3156.2012.03064.x","article-title":"Latent class analysis of diagnostic tests for visceral leishmaniasis in Brazil","volume":"17","author":"Machado de Assis TS","year":"2012","journal-title":"Trop Med Int Health"},{"key":"ref4","series-title":"Visceral leishmaniasis rapid diagnostic test performance","year":"2011"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1590\/S0074-02762012000700019","article-title":"Performance of the Kala-Azar detect and IT LEISH rapid tests for the diagnosis of visceral leishmaniasis in Brazil","volume":"107","author":"Perhuype-Magalh\u00e3es V","year":"2012","journal-title":"Men Inst Oswaldo Cruz"},{"key":"ref6","series-title":"Recomenda\u00e7\u00f5es cl\u00ednicas para redu\u00e7\u00e3o da letalidade","year":"2011"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"3147","DOI":"10.1128\/JCM.00372-14","article-title":"Molecular tools for diagnosis of visceral leishmaniasis: systematic review and meta-analysis of diagnostic test accuracy","volume":"52","author":"Ruiter CM","year":"2014","journal-title":"J Clin Microbiol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1093\/trstmh\/trt004","article-title":"Validation of a direct agglutination test prototype kit for the diagnosis of visceral leishmaniasis","volume":"107","author":"Oliveira E","year":"2013","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"570","DOI":"10.4269\/ajtmh.13-0239","article-title":"Comparison of parasitological, serological, and molecular tests for visceral leishmaniasis in HIV-infected patients: a cross-sectional delayed-type study","volume":"89","author":"Cota GF","year":"2013","journal-title":"Am J Trop Med Hyg"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1093\/trstmh\/trw050","article-title":"Cost-effectiveness analysis of diagnostic tests for human visceral leishmaniasis in Brazil","volume":"110","author":"Machado de Assis TS","year":"2016","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref11","series-title":"Diretrizes metodol\u00f3gicas. 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