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Sa\u00fade P\u00fablica"],"abstract":"<jats:p>Abstract: Varicella in adults and immunocompromised patients can be severe. The clinical diagnosis of varicella has high accuracy and the history of disease has a high positive predictive value for protection. A significant portion of adults, however, cannot remember if they have had varicella, especially older individuals. We conducted a cross-sectional study to determine the seroprevalence of varicella protective antibodies titers in adults with no clinical history of disease, attended at a Reference Center for Special Immunobiologicals and Travel Medicine in Rio de Janeiro (Brazil). Titration of immunoglobulin G (IgG) antibodies to varicella-zoster was determined by chemiluminescence immunoassay. Among 140 adults without history of varicella, 92% had protective antibody titers. We concluded that seroprevalence of varicella-zoster protection was very high in adults with negative history of disease and the use of serology before vaccination reduced significantly unnecessary vaccine and immunoglobulin use.<\/jats:p>","DOI":"10.1590\/0102-311x00149119","type":"journal-article","created":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T09:51:45Z","timestamp":1579600305000},"source":"Crossref","is-referenced-by-count":3,"title":["Seroprevalence of varicella antibodies in adults without clinical history of disease"],"prefix":"10.1590","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5737-6709","authenticated-orcid":false,"given":"Konrad Silva","family":"B\u00fcchele","sequence":"first","affiliation":[{"name":"Marinha do Brasil, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6121-6919","authenticated-orcid":false,"given":"Danusa Ferreira","family":"Correa","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0082-5155","authenticated-orcid":false,"given":"Mari","family":"Tuyama","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0138-6577","authenticated-orcid":false,"given":"Alberto dos Santos de","family":"Lemos","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2493-5583","authenticated-orcid":false,"given":"Marcellus Dias da","family":"Costa","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5132-3315","authenticated-orcid":false,"given":"Emersom Cicilini","family":"Mesquita","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8630-3245","authenticated-orcid":false,"given":"Daniel Marinho da","family":"Costa","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9254-917X","authenticated-orcid":false,"given":"Jos\u00e9","family":"Cerbino-Neto","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8161-1158","authenticated-orcid":false,"given":"Margareth Catoia","family":"Varela","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6700-2268","authenticated-orcid":false,"given":"Pedro Emmanuel Americano Alvarenga do","family":"Brasil","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5271-422X","authenticated-orcid":false,"given":"Luciana Gomes Pedro","family":"Brand\u00e3o","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2020]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1128\/CMR.9.3.361","article-title":"Varicella-zoster virus","volume":"9","author":"Arvin AM","year":"1996","journal-title":"Clin Microbiol Rev"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1542\/peds.68.1.14","article-title":"Age-specific risks of varicella complications","volume":"68","author":"Preblud SR","year":"1981","journal-title":"Pediatrics"},{"key":"ref3","series-title":"Epidemiology and prevention of vaccine-preventable diseases. 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