{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T02:46:20Z","timestamp":1793501180720,"version":"4.5.0"},"reference-count":41,"publisher":"FapUNIFESP (SciELO)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cad. Sa\u00fade P\u00fablica"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:p>The objective of this study was to analyze the impact of vaccination against Streptococcus pneumoniae on the morbidity and mortality from pneumococcal meningitis in children \u2264 2 years in Brazil, from 2007 to 2012. This is a descriptive study and ecological analysis using data from the Information System on Notifiable Diseases. Pre-vaccination (2007-2009) and post-vaccination (2011-2012) periods were defined to compare incidence rates and mortality. A total of 1,311 cases and 430 deaths were reported during the study period. Incidence decreased from 3.70\/100,000 in 2007 to 1.84\/100,000 in 2012, and mortality decreased from 1.30\/100,000 to 0.40\/100,000, or 50% and 69% respectively, with the greatest impact in the 6-11 month age group. This decrease in Pneumococcal meningitis morbidity and mortality rates two years after introduction of the 10-valent pneumococcal conjugate vaccine suggests its effectiveness.<\/jats:p>","DOI":"10.1590\/0102-311x00169913","type":"journal-article","created":{"date-parts":[[2015,3,4]],"date-time":"2015-03-04T16:48:30Z","timestamp":1425487710000},"page":"276-284","source":"Crossref","is-referenced-by-count":24,"title":["Impact of 10-valent pneumococcal conjugate vaccine on pneumococcal meningitis in children up to two years of age in Brazil"],"prefix":"10.1590","volume":"31","author":[{"given":"Indianara Maria","family":"Grando","sequence":"first","affiliation":[{"name":"Universidade de Bras\u00edlia,  Brasil; Minist\u00e9rio da Sa\u00fade,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camile de","family":"Moraes","sequence":"additional","affiliation":[{"name":"Minist\u00e9rio da Sa\u00fade,  Brasil; Universidade de Bras\u00edlia,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendan","family":"Flannery","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention,  U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter Massa","family":"Ramalho","sequence":"additional","affiliation":[{"name":"Universidade de Bras\u00edlia,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco Aur\u00e9lio P.","family":"Horta","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana Lucia Moura","family":"Pinho","sequence":"additional","affiliation":[{"name":"Universidade de Bras\u00edlia,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilmara Lima","family":"Nascimento","sequence":"additional","affiliation":[{"name":"Universidade de Bras\u00edlia,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"key":"ref1","first-page":"93","article-title":"Pneumococcal conjugate vaccine for childhood immunization: WHO position paper","volume":"82","year":"2007","journal-title":"Wkly Epidemiol Rec"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/S0140-6736(09)61204-6","article-title":"Burden of disease caused by Streptococcus pneumoniae in children younger than 5 years: global estimates","volume":"374","author":"O'Brien KL","year":"2009","journal-title":"Lancet"},{"key":"ref3","series-title":"Proceedings of the Sixth Global Vaccine Research Forum and Parallel Satellite Symposia","year":"2006"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"3970","DOI":"10.1128\/JCM.41.8.3970-3972.2003","article-title":"Genetic relationship between Streptococcus pneumoniae isolates from nasopharyngeal and cerebrospinal fluid of two infants with pneumococcal meningitis","volume":"41","author":"Andrade ALSS","year":"2003","journal-title":"J Clin Microbiol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1590\/S0021-75572002000100006","article-title":"Meningite pneumoc\u00f3cica em crian\u00e7as: achados cl\u00ednicos, sorotipos mais frequentes e progn\u00f3stico","volume":"78","author":"Berezin EN","year":"2002","journal-title":"J Pediatr (Rio J.)"},{"key":"ref6","first-page":"511","article-title":"Vaccine preventable deaths and the Global Immunization Vision and Strategy, 2006-2015","volume":"55","year":"2006","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"4","key":"ref7","first-page":"CD004977","article-title":"Pneumococcal conjugate vaccines for preventing vaccine-type invasive pneumococcal disease and X-ray defined pneumonia in children less than two years of age","author":"Lucero MG","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1157\/13106935","article-title":"Enfermedad neumoc\u00f3cica invasiva en la poblaci\u00f3n menor de 5 a\u00f1os de edad de Navarra (2000-2005): impacto de la vacuna conjugada","volume":"129","author":"Barricarte A","year":"2007","journal-title":"Med Clin (Barc),"},{"key":"ref9","series-title":"Epidemiology and prevention of vaccine-preventable diseases.10th Ed","author":"Atkinson W","year":"2008"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s12325-013-0007-6","article-title":"The impact of 7-valent pneumococcal conjugate vaccine on invasive pneumococcal disease: a literature review","volume":"30","author":"Myint TTH","year":"2013","journal-title":"Adv Ther"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"816","DOI":"10.3201\/eid1605.091223","article-title":"Effects of pneumococcal conjugate vaccine 2 years after its introduction, the Netherlands","volume":"16","author":"Rodenburg GD","year":"2010","journal-title":"Emerg Infect Dis"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1086\/648593","article-title":"Sustained reductions in invasive pneumococcal disease in the era of conjugate vaccine","volume":"201","author":"Pilishvili T","year":"2010","journal-title":"J Infect Dis"},{"key":"ref13","series-title":"Guia de vigil\u00e2ncia epidemiol\u00f3gica.7\u00aa Ed","year":"2010"},{"key":"ref14","series-title":"Expert Committee on Biological Standardization.Recommendations to assure the quality, safety and efficacy of pneumococcal conjugate vaccines","year":"2009"},{"key":"ref15","article-title":"Bacterial meningitis in Brazil: baseline epidemiologic assessment of the decade prior to the introduction of pneumococcal and meningococcal vaccines","volume":"8","author":"Azevedo LCP","year":"2013","journal-title":"PLoS One"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1056\/NEJMoa022823","article-title":"Decline in invasive pneumococcal disease after the introduction of protein-polysaccharide conjugate vaccine","volume":"348","author":"Whitney CG","year":"2003","journal-title":"N Engl J Med"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1503\/cmaj.051150","article-title":"Progress in the prevention of pneumococcal infection","volume":"173","author":"Kellner JD","year":"2005","journal-title":"CMAJ"},{"key":"ref18","first-page":"86","article-title":"Invasive pneumococcal disease in Australia, 2005","volume":"31","author":"Roche P","year":"2007","journal-title":"Commun Dis Intell Q Rep"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1097\/01.inf.0000148891.32134.36","article-title":"Population based surveillance for childhood invasive pneumococcal disease in the era of conjugate vaccine","volume":"24","author":"Hsu K","year":"2005","journal-title":"Pediatr Infect Dis J"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1097\/01.inf.0000129685.04847.94","article-title":"Postlicensure surveillance for pneumococcal invasive disease after use of heptavalent pneumococcal conjugate vaccine in Northern California Kaiser Permanente","volume":"23","author":"Black S","year":"2004","journal-title":"Pediatr Infect Dis J"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1001\/jama.295.14.1668","article-title":"Invasive pneumococcal disease among infants before and after introduction of pneumococcal conjugate vaccine","volume":"295","author":"Poehling KA","year":"2006","journal-title":"JAMA"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1542\/peds.113.3.443","article-title":"Decrease of invasive pneumococcal infections in children among 8 children's hospitals in the United States after the introduction of the 7-valent pneumococcal conjugate vaccine","volume":"113","author":"Kaplan SL","year":"2004","journal-title":"Pediatrics,"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1056\/NEJMoa0800836","article-title":"Effect of pneumococcal conjugate vaccine on pneumococcal meningitis","volume":"360","author":"Hsu HE","year":"2009","journal-title":"N Engl J Med"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1136\/adc.2007.119891","article-title":"Decline in pneumococcal meningitis after the introduction of the heptavalent-pneumococcal conjugate vaccine in northern France","volume":"92","author":"Dubos F","year":"2007","journal-title":"Arch Dis Child"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1136\/thx.2006.la0208","article-title":"Infants too young to receive pneumococcal conjugate vaccine benefit from herd immunity","volume":"61","author":"Carter RJF","year":"2006","journal-title":"Thorax"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/S0140-6736(12)61854-6","article-title":"Effectiveness of the ten-valent pneumococcal Haemophilus influenzae protein D conjugate vaccine (PHiD-CV10) against invasive pneumococcal disease: a cluster randomised trial","volume":"381","author":"Palmu AA","year":"2013","journal-title":"Lancet"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"6416","DOI":"10.1016\/j.vaccine.2012.08.017","article-title":"Invasive pneumococcal diseases in birth cohorts vaccinated with PCV-7 and\/or PHiD-CV in the province of Quebec, Canada","volume":"30","author":"De Wals P","year":"2012","journal-title":"Vaccine"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/j.vaccine.2010.12.021","article-title":"Serotype distribution and antimicrobial resistance of Streptococcus pneumoniae prior to introduction of the 10-valent pneumococcal conjugate vaccine in Brazil, 2000-2007","volume":"29","author":"Menezes APO","year":"2011","journal-title":"Vaccine"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1016\/j.vaccine.2011.12.012","article-title":"Population-based surveillance for invasive pneumococcal disease and pneumonia in infants and young children in Goi\u00e2nia, Brazil","volume":"30","author":"Andrade AL","year":"2012","journal-title":"Vaccine"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1086\/521626","article-title":"Incidence of pneumococcal disease due to nonpneumococcal conjugate vaccine (PCV7) serotypes in the United States during the era of widespread PCV7 vaccination, 1998-2004","volume":"196","author":"Hicks LA","year":"2007","journal-title":"J Infect Dis"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.vaccine.2009.10.121","article-title":"Declining invasive pneumococcal disease mortality in the United States, 1990-2005","volume":"28","author":"Pulido M","year":"2010","journal-title":"Vaccine"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1056\/NEJMoa035060","article-title":"A trial of a 9-valent pneumococcal conjugate vaccine in children with and those without HIV infection","volume":"349","author":"Klugman KP","year":"2003","journal-title":"N Engl J Med"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1590\/S0021-75572002000100006","article-title":"Meningite pneumoc\u00f3cica em crian\u00e7as: achados cl\u00ednicos, sorotipos mais frequentes e progn\u00f3stico","volume":"78","author":"Berezin EN","year":"2002","journal-title":"J Pediatr (Rio J.)"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S1474-4422(05)70288-X","article-title":"Clinical features, complications, and outcome in adults with pneumococcal meningitis: a prospective case series","volume":"5","author":"Weisfelt M","year":"2006","journal-title":"Lancet Neurol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1056\/NEJM199710023371404","article-title":"Bacterial meningitis in the United States in 1995","volume":"337","author":"Schuchat A","year":"1997","journal-title":"N Engl J Med"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1097\/01.inf.0000157090.40719.9b","article-title":"Comparison of incidence of invasive Streptococcus pneumoniae disease among children before and after introduction of conjugated pneumococcal vaccine","volume":"24","author":"Haddy RI","year":"2005","journal-title":"Pediatr Infect Dis J"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1055\/s-0029-1202938","article-title":"Streptococcus pneumoniae: epidemiology, risk factors, and strategies for prevention","volume":"30","author":"Lynch 3 JP","year":"2009","journal-title":"Semin Respir Crit Care Med"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1056\/NEJMp048246","article-title":"Bacterial meningitis: a view of the past 90 years","volume":"351","author":"Swartz MN","year":"2004","journal-title":"N Engl J Med"},{"key":"ref39","first-page":"16","article-title":"Estimation du nombre total de m\u00e8ningites \u00e0 pneumocoque de l'enfant, par la m\u00e9thode capture-recapture \u00e0 3 sources, France, 2001-2002","volume":"2-3","author":"Perrocheau A","year":"2006","journal-title":"Bull Epidemiol Hebd"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1056\/NEJMoa0800836","article-title":"Effect of pneumococcal conjugate vaccine on pneumococcal meningitis","volume":"360","author":"Hsu HE","year":"2009","journal-title":"N Engl J Med"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"589","DOI":"10.3201\/eid1904.121198","article-title":"Effect of 10-valent pneumococcal vaccine on pneumonia among children, Brazil","volume":"19","author":"Afonso ET","year":"2013","journal-title":"Emerg Infect Dis"}],"container-title":["Cadernos de Sa\u00fade P\u00fablica"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/csp\/v31n2\/0102-311X-csp-31-02-00276.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,5,22]],"date-time":"2017-05-22T23:12:50Z","timestamp":1495494770000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0102-311X2015000200276&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["S0102-311X2015000200276"],"URL":"https:\/\/doi.org\/10.1590\/0102-311x00169913","relation":{},"ISSN":["0102-311X"],"issn-type":[{"value":"0102-311X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2]]}}}