{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:51:38Z","timestamp":1790700698541,"version":"4.1.0"},"reference-count":83,"publisher":"FapUNIFESP (SciELO)","issue":"6","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cad. Sa\u00fade P\u00fablica"],"abstract":"<jats:p>Abstract: Dengue is an important arthropod-borne viral disease in terms of morbidity, mortality, economic impact and challenges in vector control. Benchmarks are expensive, time consuming and require trained personnel. Preventing dengue complications with rapid diagnosis has been based on the testing of easy-to-perform optimized immunochromatographic methods (ICT). This is a systematic meta-analysis review of the diagnostic accuracy of IgA, NS1, IgM and\/or IgG ICT studies in suspected cases of acute or convalescent dengue, using a combination of RT-PCR, ELISA NS1, IgM IgG or viral isolation as a reference standard. This protocol was registered in PROSPERO (CRD42014009885). Two pairs of reviewers searched the PubMed, BIREME, Science Direct, Scopus, Web of Science, Ovid MEDLINE JBrigs, SCIRUS and EMBASE databases, selected, extracted, and quality-assessed by QUADAS 2. Of 3,783 studies, we selected 57, of which 40 in meta-analyses according to the analyte tested, with high heterogeneity (I2 &gt; 90%), as expected for diagnostic tests. We detected higher pooled sensitivity in acute phase IgA (92.8%) with excellent (90%) specificity. ICT meta-analysis with NS1\/IgM\/IgG showed 91% sensitivity and 96% specificity. Poorer screening performance was for IgM\/IgG ICT (sensitivity = 56%). Thus, the studies with NS1\/IgM\/IgG ICT showed the best combined performance in the acute phase of the disease.<\/jats:p>","DOI":"10.1590\/0102-311x00225618","type":"journal-article","created":{"date-parts":[[2020,6,7]],"date-time":"2020-06-07T12:26:12Z","timestamp":1591532772000},"source":"Crossref","is-referenced-by-count":15,"title":["Rapid immunochromatographic tests for the diagnosis of dengue: a systematic review and meta-analysis"],"prefix":"10.1590","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4203-7608","authenticated-orcid":false,"given":"Ver\u00f3nica Elizabeth","family":"Mata","sequence":"first","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0098-4957","authenticated-orcid":false,"given":"Carlos Augusto Ferreira de","family":"Andrade","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9947-2291","authenticated-orcid":false,"given":"Sonia Regina Lambert","family":"Passos","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7140-7172","authenticated-orcid":false,"given":"Yara Hahr Marques","family":"H\u00f6kerberg","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0617-9948","authenticated-orcid":false,"given":"Levy Vilas Boas","family":"Fukuoka","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6271-2829","authenticated-orcid":false,"given":"Suzana Alves da","family":"Silva","sequence":"additional","affiliation":[{"name":"Hospital do Cora\u00e7\u00e3o, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2020]]},"reference":[{"issue":"12 Suppl","key":"ref1","doi-asserted-by":"crossref","first-page":"S30","DOI":"10.1038\/nrmicro2459","article-title":"Evaluation of diagnostic tests dengue","volume":"8","author":"Peeling RW","year":"2010","journal-title":"Nat Rev Microbiol"},{"key":"ref2","article-title":"A meta-analysis of the diagnostic accuracy of two commercial NS1 antigen ELISA tests for early dengue virus detection","volume":"9","author":"Da Costa VG","year":"2014","journal-title":"PLoS One"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"128","DOI":"10.4269\/ajtmh.2010.09-0346","article-title":"The epidemiology of dengue in the americas over the last three decades a worrisome reality","volume":"82","author":"San Martin JL","year":"2010","journal-title":"Am J Trop 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