{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T08:08:32Z","timestamp":1769242112791,"version":"3.49.0"},"reference-count":51,"publisher":"FapUNIFESP (SciELO)","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cad. Sa\u00fade P\u00fablica"],"abstract":"<jats:p>This study aims to investigate factors associated with serum 25-hydroxyvitamin D [25(OH)D] concentration in Brazilian adults considering sociodemographic and lifestyle factors, as well as vitamin D-related single nucleotide polymorphisms (SNPs). This is a cross-sectional study (n = 491; 34-79y\u037e 251 women), nested within a prospective cohort (Pr\u00f3-Sa\u00fade Study). Associations between serum 25(OH)D and sociodemographic characteristics, diet, use of supplement, physical activity, season of blood collection, body fat, skin type, sun exposure index, and SNPs CYP2R1-rs10741657 and GC-rs2282679 were explored by multiple linear regression. The prevalence of serum 25(OH)D &lt; 50nmol\/L was 55%. Serum 25(OH)D was lower among women (\u03b2 = -4.38; 95%CI: -8.02; -0.74), those with higher visceral fat (\u03b2 = -4.02; 95%CI: -5.92; -2.12), and those with AC and CC genotypes for GC-rs2282679 (\u03b2 = -6.84; 95%CI: -10.09; -3.59; \u03b2 = -10.63; 95%CI: -17.52; -3.74, respectively). Factors directly associated with serum 25(OH)D included summer (\u03b2 = 20.14; 95%CI: 14.38; 25.90), intermediate skin type (\u03b2 = 6.16; 95%CI: 2.52; 9.80), higher sun exposure (\u03b2 = 0.49; 95%CI: 0.22; 0.75), vitamin D intake (\u03b2 = 0.48; 95%CI: 0.03; 0.93), and physical activity (\u03b2 = 4.65; 95%CI: 1.54; 7.76). Besides physical activity, diet, and sun exposure, non-modifiable factors, such as GC genotypes must be considered when evaluating vitamin D insufficiency in mixed-race populations. Moreover, high visceral fat in association with poorer vitamin D status deserve attention given that both conditions are unfavorably related with chronic and acute health outcomes.<\/jats:p>","DOI":"10.1590\/0102-311x00287820","type":"journal-article","created":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T12:03:38Z","timestamp":1641989018000},"source":"Crossref","is-referenced-by-count":5,"title":["Genetic, sociodemographic and lifestyle factors associated with serum 25-hydroxyvitamin D concentrations in Brazilian adults: the Pr\u00f3-Sa\u00fade Study"],"prefix":"10.1590","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6594-4323","authenticated-orcid":false,"given":"Fl\u00e1via Fioruci","family":"Bezerra","sequence":"first","affiliation":[{"name":"Universidade do Estado do Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6443-7733","authenticated-orcid":false,"given":"Paula","family":"Normando","sequence":"additional","affiliation":[{"name":"Universidade do Estado do Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6123-0481","authenticated-orcid":false,"given":"Ana Carolina P.","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0044-3210","authenticated-orcid":false,"given":"Ver\u00f4nica","family":"Zembrzuski","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7121-0748","authenticated-orcid":false,"given":"Mario","family":"Campos-Junior","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1389-5064","authenticated-orcid":false,"given":"Pedro Hernan","family":"Cabello-Acero","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4027-4896","authenticated-orcid":false,"given":"Eduardo","family":"Faerstein","sequence":"additional","affiliation":[{"name":"Universidade do Estado do Rio de Janeiro, 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