{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:05:13Z","timestamp":1753887913187,"version":"3.41.2"},"reference-count":38,"publisher":"FapUNIFESP (SciELO)","issue":"11","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cad. Sa\u00fade P\u00fablica"],"abstract":"<jats:p>A leishmaniose visceral (LV) ou calazar \u00e9 uma das principais doen\u00e7as tropicais negligenciadas, de grande import\u00e2ncia devido ao car\u00e1ter letal desta zoonose causada por protozo\u00e1rios do g\u00eanero Leishmania. Objetivou-se analisar a tend\u00eancia temporal dos casos de LV no Estado do Piau\u00ed, Brasil, de 2008 a 2018, inserindo-o dentro do per\u00edodo total de 1971 a 2018. Utilizaram-se dados do Sistema de Informa\u00e7\u00e3o de Agravos de Notifica\u00e7\u00e3o (SINAN) e do Sistema de Informa\u00e7\u00f5es sobre Mortalidade (SIM). Para an\u00e1lise da carga da doen\u00e7a, foram coletados dados do Instituto de M\u00e9tricas e Avalia\u00e7\u00e3o em Sa\u00fade atrav\u00e9s do estudo Carga Global de Doen\u00e7as, Les\u00f5es e Fatores de Risco. Foi empregada a an\u00e1lise de regress\u00e3o Prais-Winsten. Foram registrados 2.374 casos com prov\u00e1vel local de infec\u00e7\u00e3o no Piau\u00ed e 2.492 casos em residentes do estado. A s\u00e9rie hist\u00f3rica analisada, de 1971 a 2018, reafirma o car\u00e1ter c\u00edclico da doen\u00e7a, pela presen\u00e7a dos picos epid\u00eamicos identificados em 1983 e 1984, 1993 e 1994, 2003 e 2004 e 2013 e 2014. N\u00e3o foram identificadas altera\u00e7\u00f5es significativas na tend\u00eancia dos coeficientes de incid\u00eancia, mortalidade e letalidade no estado. No entanto, houve aumento significativo do coeficiente de incid\u00eancia no Territ\u00f3rio de Desenvolvimento (TD) Chapada das Mangabeiras (varia\u00e7\u00e3o percentual anual de 17,5%) e redu\u00e7\u00e3o no TD Vale do Sambito (-18,3%) e TD Vale do Rio Guaribas (-8,1%). A LV tem a maior carga de doen\u00e7a medida em anos de vida ajustados por defici\u00eancia entre as doen\u00e7as tropicais negligenciadas do estado. Recomenda-se o aprimoramento das medidas de vigil\u00e2ncia e controle do agravo.<\/jats:p>","DOI":"10.1590\/0102-311x00340320","type":"journal-article","created":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T12:19:32Z","timestamp":1638361172000},"source":"Crossref","is-referenced-by-count":5,"title":["Perfil epidemiol\u00f3gico e tend\u00eancia temporal da leishmaniose visceral: Piau\u00ed, Brasil, 2008 a 2018"],"prefix":"10.1590","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0351-8994","authenticated-orcid":false,"given":"Francisca Miriane de Ara\u00fajo","family":"Batista","sequence":"first","affiliation":[{"name":"Universidade Federal do Piau\u00ed,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3104-5925","authenticated-orcid":false,"given":"Roniele Ara\u00fajo de","family":"Sousa","sequence":"additional","affiliation":[{"name":"Universidade Nova de Lisboa,  Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7986-1759","authenticated-orcid":false,"given":"Bruno Guedes Alcoforado","family":"Aguiar","sequence":"additional","affiliation":[{"name":"Universidade Federal do Piau\u00ed,  Brazil; Centro de Intelig\u00eancia em Agravos Tropicais Emergentes e Negligenciado,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3942-9117","authenticated-orcid":false,"given":"Andressa Barros","family":"Ibiapina","sequence":"additional","affiliation":[{"name":"Universidade Federal do Piau\u00ed,  Brazil; Centro de Intelig\u00eancia em Agravos Tropicais Emergentes e Negligenciado,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3714-787X","authenticated-orcid":false,"given":"Layana Pach\u00eaco de Ara\u00fajo","family":"Albuquerque","sequence":"additional","affiliation":[{"name":"Universidade Federal do Piau\u00ed,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0838-6764","authenticated-orcid":false,"given":"Vagner Jos\u00e9","family":"Mendon\u00e7a","sequence":"additional","affiliation":[{"name":"Universidade Federal do Piau\u00ed,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7302-2006","authenticated-orcid":false,"given":"Carlos Henrique Nery","family":"Costa","sequence":"additional","affiliation":[{"name":"Universidade Federal do Piau\u00ed,  Brazil; Instituto de Doen\u00e7as Tropicais Natan Portella,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2021]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"9375","DOI":"10.1073\/pnas.0703678104","article-title":"Evolutionary and geographical history of the Leishmania donovani complex with a revision of current taxonomy","volume":"104","author":"Lukes J","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"edition":"2\u00aa","year":"2017","series-title":"Guia de vigil\u00e2ncia em sa\u00fade.","key":"ref2"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1590\/1519-6984.166622","article-title":"Epidemiological aspects of human and canine visceral leishmaniasis in State of Alagoas, Northeast, Brazil","volume":"78","author":"Rocha M","year":"2018","journal-title":"Braz J Biol"},{"key":"ref4","article-title":"Human visceral leishmaniasis epidemiological, temporal and spacial aspects in Northeast Brazil, 2003-2017","volume":"62","author":"Cavalcante FRA","year":"2020","journal-title":"Rev Inst Med Trop S\u00e3o Paulo"},{"year":"2020","series-title":"Atlas interactivo de leishmaniasis en las Am\u00e9ricas: aspectos cl\u00ednicos y diagn\u00f3sticos diferenciales","key":"ref5"},{"series-title":"Leishmaniasis.","key":"ref6"},{"year":"2019","series-title":"Manual de procedimientos para vigilancia y control de las leishmaniasis en las Am\u00e9ricas","key":"ref7"},{"year":"2019","series-title":"Leishmanioses: informe epidemiol\u00f3gico das Am\u00e9ricas. 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