{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T20:52:43Z","timestamp":1765486363812,"version":"3.41.2"},"reference-count":34,"publisher":"FapUNIFESP (SciELO)","issue":"10","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cad. Sa\u00fade P\u00fablica"],"abstract":"<jats:p>Resumo: A osteoartrite de joelho afeta cerca de 3,8% da popula\u00e7\u00e3o mundial e se manifesta por dor, edema, rigidez e redu\u00e7\u00e3o da fun\u00e7\u00e3o articular, impactando na qualidade de vida do paciente. O tratamento consiste na modalidade farmacol\u00f3gica, n\u00e3o farmacol\u00f3gica e cir\u00fargica. A viscossuplementa\u00e7\u00e3o (\u00e1cido hialur\u00f4nico intra-articular) se prop\u00f5e a oferecer al\u00edvio dos sintomas e a possibilidade de adiamento da cirurgia. Este estudo estimou o impacto or\u00e7ament\u00e1rio entre a associa\u00e7\u00e3o desse medicamento e o tratamento n\u00e3o cir\u00fargico (tratamento padr\u00e3o), sob a perspectiva do Sistema \u00danico de Sa\u00fade. Com base no pressuposto de que 5% dos portadores da doen\u00e7a seguem para tratamento e nos custos diretos das modalidades: farmacol\u00f3gica e n\u00e3o farmacol\u00f3gica foram calculados os cen\u00e1rios de refer\u00eancia e alternativos que compararam as diferentes op\u00e7\u00f5es de tratamento para um horizonte temporal de tr\u00eas anos. A an\u00e1lise principal estimou um impacto or\u00e7ament\u00e1rio incremental de aproximadamente R$ 126 milh\u00f5es (1 ampola anual) e R$ 252 milh\u00f5es (2 ampolas anuais). J\u00e1 a diacere\u00edna, um condroprotetor oral, avaliada como uma op\u00e7\u00e3o alternativa, mostrou um impacto de R$ 334 milh\u00f5es no or\u00e7amento em rela\u00e7\u00e3o ao tratamento padr\u00e3o, o que proporciona um aumento de 24% no custo em rela\u00e7\u00e3o ao uso de 2 ampolas anuais de \u00e1cido hialur\u00f4nico, tornando-a economicamente menos vantajosa. A viscossuplementa\u00e7\u00e3o pode proporcionar maior qualidade de vida ao paciente, redu\u00e7\u00e3o de custos para o sistema e otimiza\u00e7\u00e3o do fluxo de atendimento nas unidades de sa\u00fade. As estimativas apresentadas neste estudo podem auxiliar o gestor quanto \u00e0 melhor utiliza\u00e7\u00e3o dos recursos financeiros e consequente tomada de decis\u00e3o quanto \u00e0 incorpora\u00e7\u00e3o da tecnologia.<\/jats:p>","DOI":"10.1590\/0102-311x098618","type":"journal-article","created":{"date-parts":[[2019,10,5]],"date-time":"2019-10-05T19:28:04Z","timestamp":1570303684000},"source":"Crossref","is-referenced-by-count":2,"title":["An\u00e1lise do impacto or\u00e7ament\u00e1rio da viscossuplementa\u00e7\u00e3o no tratamento n\u00e3o cir\u00fargico da osteoartrite de joelho"],"prefix":"10.1590","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7332-0633","authenticated-orcid":false,"given":"Grasiela Martins da","family":"Silva","sequence":"first","affiliation":[{"name":"Instituto Nacional de Traumatologia e Ortopedia Jamil Haddad, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3583-2072","authenticated-orcid":false,"given":"Katia Marie Sim\u00f5es e","family":"Senna","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Cardiologia, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8577-6403","authenticated-orcid":false,"given":"Eduardo Branco de","family":"Sousa","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Traumatologia e Ortopedia Jamil Haddad, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6890-0705","authenticated-orcid":false,"given":"Bernardo Rangel","family":"Tura","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Cardiologia, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2019]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"574","DOI":"10.2105\/AJPH.74.6.574","article-title":"Epidemiology of musculoskeletal impairments and associated disability","volume":"74","author":"Cunningham LS","year":"1984","journal-title":"Am J Public Health"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"21","DOI":"10.13172\/2053-2040-1-3-1116","article-title":"Epidemiology of knee osteoarthritis","volume":"1","author":"Muraki S","year":"2013","journal-title":"OA Sports Medicine"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1136\/annrheumdis-2013-204763","article-title":"The global burden of hip and knee osteoarthritis estimates from the global burden of disease 2010 study","volume":"73","author":"Cross M","year":"2014","journal-title":"Ann Rheum 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