{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T12:06:21Z","timestamp":1784549181678,"version":"3.55.0"},"reference-count":37,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cad. Sa\u00fade P\u00fablica"],"abstract":"<jats:p>Abstract: The objective was to estimate temporal trends for lung cancer mortality in Brazil and its regions, stratified by sex and age group, from 2021 to 2045. This mortality projection study was based on lung cancer deaths (ICD-10: C33-C34) registered in the Brazilian Mortality Information System between 2001 and 2020, with redistribution of ill-defined causes. Crude and age-adjusted rates were calculated according to the 1960 world standard population. The projections adopted the Nordpred model in the R program, in 5-year periods from 2021 to 2045. There was a projected increase in the absolute number of deaths in both sexes, especially in the South and Southeast regions. The age-adjusted rates indicate a downward trend among men in all regions, despite remaining higher in the South. Among women, there was growth by 2025, followed by stability or a slight reduction by 2045, with the highest rates in the South Region. Population aging contributes to the increase in crude rates, even with the decline in adjusted rates. The projections suggest persistent regional inequalities, which may be associated with historical smoking patterns and unequal access to lung cancer diagnosis and treatment. The findings reinforce the need for regional prevention and control policies, including addressing smoking and considering the new forms of nicotine consumption, such as electronic cigarettes.<\/jats:p>","DOI":"10.1590\/0102-311xen199725","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T11:24:27Z","timestamp":1784546667000},"source":"Crossref","is-referenced-by-count":0,"title":["Projections for lung cancer mortality in Brazil by 2045: a regional analysis"],"prefix":"10.1590","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3067-0526","authenticated-orcid":false,"given":"Rejane de Souza","family":"Reis","sequence":"first","affiliation":[{"name":"Funda\u00e7\u00e3o do C\u00e2ncer,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7815-4304","authenticated-orcid":false,"given":"Fernanda Cristina da Silva de","family":"Lima","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o do C\u00e2ncer,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4726-3510","authenticated-orcid":false,"given":"Darlan Henrique Nascimento da","family":"Silva","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o do C\u00e2ncer,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3293-1689","authenticated-orcid":false,"given":"Alfredo Jos\u00e9 Monteiro","family":"Scaff","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o do C\u00e2ncer,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1903-6188","authenticated-orcid":false,"given":"Andr\u00e9 Salem","family":"Szklo","sequence":"additional","affiliation":[{"name":"Instituto Nacional de C\u00e2ncer,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2026]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"3029","DOI":"10.1002\/cncr.33587","article-title":"The ever-increasing importance of cancer as a leading cause of premature death worldwide","volume":"127","author":"Bray F","year":"2021","journal-title":"Cancer"},{"key":"ref2","series-title":"Cancer today. Absolute numbers, incidence, both sexes, in 2022."},{"key":"ref3","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.","volume":"71","author":"Hh Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"ref4","series-title":"Informa\u00e7\u00e3o e preven\u00e7\u00e3o."},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1016\/S0140-6736(05)67725-2","article-title":"Causes of cancer in the world comparative risk assessment of nine behavioural and environmental risk factors","volume":"366","author":"Danaei G","year":"2005","journal-title":"Lancet"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1001\/jamaoncol.2022.7826","article-title":"Estimates and projections of the global economic cost of 29 cancers in 204 countries and territories from 2020 to 2050","volume":"9","author":"Chen S","year":"2023","journal-title":"JAMA Oncol"},{"key":"ref7","doi-asserted-by":"crossref","DOI":"10.32635\/2176-9745.RBC.2023v69n1.3700","article-title":"Estimativa de incid\u00eancia de c\u00e2ncer no Brasil, 2023-2025","volume":"69","author":"Santos MO","year":"2023","journal-title":"Rev Bras Cancerol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"101736","DOI":"10.1016\/j.canep.2020.101736","article-title":"The tobacco epidemic curve in Brazil where are we going?","volume":"67","author":"Souza MC","year":"2020","journal-title":"Cancer Epidemiol"},{"key":"ref9","article-title":"Lei n\u00ba 14.758, de 19 de dezembro de 2023. Institui a Pol\u00edtica Nacional de Preven\u00e7\u00e3o e Controle do C\u00e2ncer no \u00e2mbito do Sistema \u00danico de Sa\u00fade (PNPCC) e o Programa Nacional de Navega\u00e7\u00e3o da Pessoa com Diagn\u00f3stico de C\u00e2ncer; altera a Lei n\u00ba 8.080, de 19 de setembro de 1990.","year":"2023","journal-title":"Di\u00e1rio Oficial da Uni\u00e3o"},{"key":"ref10","series-title":"Plano de a\u00e7\u00f5es estrat\u00e9gicas para o enfrentamento das doen\u00e7as cr\u00f4nicas n\u00e3o transmiss\u00edveis no Brasil 2021-2030","year":"2021"},{"key":"ref11","series-title":"Mortalidade - desde 1996 pela CID-10."},{"key":"ref12","series-title":"Proje\u00e7\u00e3o da popula\u00e7\u00e3o."},{"key":"ref13","series-title":"Classifica\u00e7\u00e3o estat\u00edstica internacional de doen\u00e7as e problemas relacionados \u00e0 sa\u00fade - CID-10.","volume":"1","year":"1997","edition":"10\u00aa rev."},{"key":"ref14","series-title":"Cancer mortality for selected sites in 24 countries (1950-1957)","author":"Segi M","year":"1960"},{"key":"ref15","series-title":"Cancer incidence in five continents.","volume":"I","author":"Doll R","year":"1966"},{"key":"ref16","first-page":"1418","article-title":"Impact of screening on cervical cancer incidence and mortality in a Northern Brazilian city","volume":"16","author":"Formigosa LAC","year":"2022","journal-title":"Ecancermedicalscience"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/s12885-021-07853-1","article-title":"Colorectal cancer incidence and mortality trends by sex and population group in South Africa 2002-2014","volume":"21","author":"Motsuku L","year":"2021","journal-title":"BMC Cancer"},{"key":"ref18","series-title":"Nordpred: fit power5 and Poisson age-period-cohort models to calculate prediction of cancer incidence and mortality.","author":"Fekjaer H"},{"key":"ref19","first-page":"589","article-title":"Prediction of cancer incidence in the Nordic countries up to the year 2020","volume":"38","author":"M\u00f8ller B","year":"2002","journal-title":"Eur J Cancer"},{"key":"ref20","series-title":"Age-period-cohort analysis: new models, methods, and empirical applications","author":"Yang Y","year":"2013"},{"key":"ref21","series-title":"Global burden of disease in 2002: data sources, methods and results","author":"Mathers C","year":"2003"},{"key":"ref22","series-title":"Sa\u00fade Brasil 2010: uma an\u00e1lise da situa\u00e7\u00e3o de sa\u00fade e de evid\u00eancias selecionadas de impacto de a\u00e7\u00f5es de vigil\u00e2ncia em sa\u00fade.","year":"2011"},{"key":"ref23","series-title":"Pesquisa Nacional por Amostra de Domic\u00edlios: um panorama da sa\u00fade no Brasil - acesso e utiliza\u00e7\u00e3o dos servi\u00e7os, condi\u00e7\u00f5es de sa\u00fade e fatores de risco e prote\u00e7\u00e3o \u00e0 sa\u00fade 2008","year":"2010"},{"key":"ref24","series-title":"Pesquisa Nacional de Sa\u00fade 2013: percep\u00e7\u00e3o do estado de sa\u00fade, estilos de vida e doen\u00e7as cr\u00f4nicas. 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Pro\u00edbe a comercializa\u00e7\u00e3o, a importa\u00e7\u00e3o e a propaganda de quaisquer dispositivos eletr\u00f4nicos para fumar, conhecidos como cigarro eletr\u00f4nico.","year":"2009","journal-title":"Di\u00e1rio Oficial da Uni\u00e3o"},{"key":"ref33","article-title":"Resolu\u00e7\u00e3o da Diretoria Colegiada - RDC n\u00ba 855, de 23 de abril de 2024. 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