{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T17:26:38Z","timestamp":1764350798169,"version":"3.41.2"},"reference-count":41,"publisher":"FapUNIFESP (SciELO)","issue":"suppl 1","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cad. Sa\u00fade P\u00fablica"],"abstract":"<jats:p>This paper analyzed the genesis of the PrEP1519 study and feasibility conditions for its construction. A qualitative-approach study was conducted using the Bourdieusian sociology framework to reconstruct the dynamics of the social environment where PrEP1519 emerged during 2015-2018. A document analysis and ten in-depth interviews were carried out to analyze the trajectory of the project. Pre-exposure prophylaxis (PrEP) was introduced in Brazil as a public policy in 2017. The lack of scientific evidence available among the adolescent population led to the development of a demonstrative cohort study, associated with an intervention, aimed at combining the prevention and treatment of sexually transmitted infections at three sites in Brazil. PrEP1519 sought to generate evidence for global use and to help the Brazilian Ministry of Health apply PrEP among adolescents. The articulation of bureaucratic, scientific, and activist stakeholders enabled this study. The feasibility conditions for developing PrEP1519 included a favorable relationship of national organizations with international organizations, the favorable approach that public administrators had at the time towards new technologies and prevention strategies, the researchers\u2019 previous experience in studies with the target population or with PrEP, articulation efforts with social movements, civil society organizations, and other public agencies, and the integration between scientific institutions, which allowed using international resources and developing a response to the problem. Completing this study at a moment when conservatism advances in Brazil demands that the scientific community and activists closely monitor and take stances on PrEP to ensure its availability for adolescents as a public policy.<\/jats:p>","DOI":"10.1590\/0102-311xen201621","type":"journal-article","created":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T12:24:38Z","timestamp":1679919878000},"source":"Crossref","is-referenced-by-count":7,"title":["The social construction of the PrEP1519 study: conditions of possibility for advances in HIV\/AIDS prevention"],"prefix":"10.1590","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8255-1230","authenticated-orcid":false,"given":"Sandra Garrido de","family":"Barros","sequence":"first","affiliation":[{"name":"Universidade Federal da Bahia,  Brazil; Universidade Federal da Bahia,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1873-4577","authenticated-orcid":false,"given":"Sandra Assis","family":"Brasil","sequence":"additional","affiliation":[{"name":"Universidade do Estado da Bahia,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2561-088X","authenticated-orcid":false,"given":"Thais Regis Aranha","family":"Rossi","sequence":"additional","affiliation":[{"name":"Universidade Federal da Bahia,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2023]]},"reference":[{"year":"2018","series-title":"Pol\u00edtica Nacional de Aids: a constru\u00e7\u00e3o da resposta governamental \u00e0 epidemia de HIV\/aids no Brasil.","author":"Barros SG","key":"ref1"},{"series-title":"Preven\u00e7\u00e3o do HIV e da aids: a hist\u00f3ria que n\u00e3o se conta\/a hist\u00f3ria que n\u00e3o te contam.","author":"Calazans G","key":"ref2"},{"year":"2016","series-title":"Consolidated guidelines on HIV prevention, diagnosis, treatment and care for key populations, 2016 update.","key":"ref3"},{"year":"2016","series-title":"Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection: recommendations for a public health approach.","key":"ref4"},{"year":"2017","series-title":"Preven\u00e7\u00e3o combinada do HIV: bases conceituais para profissionais, trabalhadores(as) e gestores(as) de sa\u00fade.","key":"ref5"},{"key":"ref6","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2015-009021","article-title":"Pre-exposure and postexposure prophylaxes and the combination HIV prevention methods (The Combine! 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