{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T03:35:45Z","timestamp":1793504145643,"version":"4.5.0"},"reference-count":62,"publisher":"FapUNIFESP (SciELO)","issue":"7","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cad. Sa\u00fade P\u00fablica"],"abstract":"<jats:p>Resumen: La ciprofloxacina es un antibi\u00f3tico de importancia cr\u00edtica para la salud humana. El aumento de la resistencia de Escherichia coli a ciprofloxacina es un problema de salud p\u00fablica global por su importancia en el tratamiento de infecciones urinarias complicadas y otras infecciones graves; sin embargo, su prescripci\u00f3n es alta en el caribe colombiano. El objetivo fue determinar la tendencia de resistencia de E. coli a ciprofloxacina en un hospital colombiano de alta complejidad. A partir de reportes de antibiogramas, los aislados fueron categorizados seg\u00fan los criterios del Instituto de Normas Cl\u00ednicas y de Laboratorio de los Estados Unidos para cada a\u00f1o estudiado; se calcularon proporciones y se exploraron diferencias en la sensibilidad con pruebas \u03c72. Se utiliz\u00f3 la prueba de Cochran-Armitage para evaluar la tendencia de la resistencia. Valores de p \u2264 0,05 se consideraron significativos. Se analizaron 6.848 aislados, encontr\u00e1ndose una resistencia de 49,31%. Seg\u00fan el origen, la resistencia m\u00e1s alta fue en muestras comunitarias (51,96% - IC95%: 50,51; 53,41), y por tipo de muestra, en piel y tejidos (61,76% - IC95%: 56,96; 66,35) y orina (48,97% - IC95%: 47,71; 50,23). Se hall\u00f3 una tendencia al aumento en la resistencia por a\u00f1o (p &lt; 0,0001), en muestras comunitarias (p = 0,0002) y en orina (p &lt; 0,0001). La resistencia a ciprofloxacina es alta y tiende al aumento en comunidad y en orina, superando el l\u00edmite establecido para su uso a nivel ambulatorio, lo que es preocupante por la alta prescripci\u00f3n de fluoroquinolonas en la localidad.<\/jats:p>","DOI":"10.1590\/0102-311xes031723","type":"journal-article","created":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T11:35:04Z","timestamp":1724412904000},"source":"Crossref","is-referenced-by-count":7,"title":["Nueve a\u00f1os de tendencia en la resistencia a ciprofloxacina por Escherichia coli: estudio transversal en un hospital de Colombia"],"prefix":"10.1590","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5314-0216","authenticated-orcid":false,"given":"Emy Shilena Torres","family":"Villalobos","sequence":"first","affiliation":[{"name":"Universidad Cooperativa de Colombia,  Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9006-8866","authenticated-orcid":false,"given":"Jos\u00e9 Alberto Mendivil De la","family":"Ossa","sequence":"additional","affiliation":[{"name":"Universidad Cooperativa de Colombia,  Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6928-4249","authenticated-orcid":false,"given":"Yolima Pertuz","family":"Meza","sequence":"additional","affiliation":[{"name":"Universidad Cooperativa de Colombia,  Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0445-5814","authenticated-orcid":false,"given":"Andres Camilo Rojas","family":"Gulloso","sequence":"additional","affiliation":[{"name":"Universidad Cooperativa de Colombia,  Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2024]]},"reference":[{"key":"ref1","series-title":"Critically important antimicrobials for human medicine","year":"2019"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1086\/520427","article-title":"Guidelines for antimicrobial treatment of uncomplicated acute bacterial cystitis and acute pyelonephritis in women","volume":"29","author":"Warren JW","year":"1999","journal-title":"Clin Infect Dis"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1025633","DOI":"10.3389\/fpubh.2022.1025633","article-title":"The resistance mechanisms of bacteria against ciprofloxacin and new approaches for enhancing the efficacy of this antibiotic","volume":"10","author":"Shariati A","year":"2022","journal-title":"Front Public Health"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1093\/jac\/43.suppl_1.31","article-title":"The global 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