{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T18:09:59Z","timestamp":1769623799267,"version":"3.49.0"},"reference-count":42,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cad. Sa\u00fade P\u00fablica"],"abstract":"<jats:p>O estresse cr\u00f4nico est\u00e1 associado a diversas morbidades, mas seus efeitos fisiol\u00f3gicos ainda demandam maior compreens\u00e3o, especialmente em rela\u00e7\u00e3o a biomarcadores inflamat\u00f3rios. Este estudo investigou a associa\u00e7\u00e3o entre eventos estressores e n\u00edveis m\u00e9dios de prote\u00edna-C reativa (PCR) e interleucina-6 (IL-6), transversalmente (aos 18 e 22 anos) e longitudinalmente (exposi\u00e7\u00e3o aos 18 e desfecho aos 22 anos). Foram inclu\u00eddos participantes da coorte de nascimentos de Pelotas, Rio Grande do Sul, Brasil, de 1993, com dados completos nas duas idades (n = 2.871 aos 18 anos; n = 2.444 aos 22 anos). A exposi\u00e7\u00e3o foi avaliada como n\u00famero de eventos estressores (nenhum, 1, \u2265 2) e em grupos de eventos estressores (6 grupos aos 18 anos; 8 grupos aos 22 anos). Modelos de regress\u00e3o linear avaliaram as associa\u00e7\u00f5es, incluindo an\u00e1lise de intera\u00e7\u00e3o por sexo. As associa\u00e7\u00f5es n\u00e3o estratificadas foram nulas ou controversas. Ap\u00f3s estratifica\u00e7\u00e3o por sexo, observaram-se associa\u00e7\u00f5es transversais: aos 22 anos, homens expostos a abuso f\u00edsico apresentaram n\u00edveis mais elevados de PCR (\u03b2 logPCR: 0,41, IC95%: 0,04; 0,78) e IL-6 (\u03b2 logIL-6: 0,26, IC95%: 0,06; 0,46) do que os n\u00e3o expostos; aos 18 anos, mulheres expostas a mudan\u00e7as indesejadas tiveram maiores n\u00edveis de IL-6 (\u03b2: 0,15, IC95%: 0,02; 0,28), enquanto aos 22 anos, aquelas com problemas nas rela\u00e7\u00f5es apresentaram n\u00edveis mais baixos de PCR (\u03b2: -0,15, IC95%: -0,29; -0,01) em compara\u00e7\u00e3o \u00e0s n\u00e3o expostas. Os resultados sugerem que o impacto dos eventos estressores na inflama\u00e7\u00e3o varia conforme o tipo de eventos estressores, idade e sexo, possivelmente refletindo diferen\u00e7as em mecanismos biopsicol\u00f3gicos.<\/jats:p>","DOI":"10.1590\/0102-311xpt043125","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T15:09:16Z","timestamp":1769440156000},"source":"Crossref","is-referenced-by-count":0,"title":["Rela\u00e7\u00e3o entre eventos estressores e marcadores inflamat\u00f3rios em adultos jovens da coorte de nascimentos de Pelotas, Rio Grande do Sul, Brasil, 1993"],"prefix":"10.1590","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5802-0686","authenticated-orcid":false,"given":"Hellena","family":"Vieira","sequence":"first","affiliation":[{"name":"Universidade Federal de Pelotas,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2917-7320","authenticated-orcid":false,"given":"Bruna Gon\u00e7alves C. da","family":"Silva","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pelotas,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7137-1747","authenticated-orcid":false,"given":"Fernando C.","family":"Wehrmeister","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pelotas,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2996-9427","authenticated-orcid":false,"given":"Ana M. B.","family":"Menezes","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pelotas,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0068-0806","authenticated-orcid":false,"given":"Isabel","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pelotas,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6470-3352","authenticated-orcid":false,"given":"Helen","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pelotas,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2026]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1177\/1745691616646305","article-title":"A stage model of stress and disease","volume":"11","author":"Cohen S","year":"2016","journal-title":"Perspect Psychol 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