{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T23:34:56Z","timestamp":1781048096251,"version":"3.54.1"},"reference-count":33,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cad. Sa\u00fade P\u00fablica"],"abstract":"<jats:p>A tafenoquina e a primaquina s\u00e3o medicamentos utilizados no tratamento da mal\u00e1ria por Plasmodium vivax e podem causar hem\u00f3lise em pacientes com defici\u00eancia da enzima glicose-6-fosfato desidrogenase (G6PD). Recomenda-se a testagem da G6PD previamente \u00e0 administra\u00e7\u00e3o dos medicamentos. A tafenoquina e o teste quantitativo point-of-care G6PD est\u00e3o incorporados ao Sistema \u00danico de Sa\u00fade (SUS) para indiv\u00edduos maiores de 16 anos, mas n\u00e3o est\u00e3o dispon\u00edveis para pacientes menores e de certas faixas de peso. A testagem para todos os pacientes eleg\u00edveis ao tratamento com primaquina tamb\u00e9m n\u00e3o \u00e9 oferecida no SUS. O objetivo deste estudo foi calcular o impacto or\u00e7ament\u00e1rio incremental da incorpora\u00e7\u00e3o da tafenoquina seguida da testagem da defici\u00eancia de G6PD para menores de 16 anos e por peso. Incluiu-se tamb\u00e9m a amplia\u00e7\u00e3o da testagem para os pacientes eleg\u00edveis ao tratamento com a primaquina. A perspectiva da an\u00e1lise \u00e9 a do SUS para um horizonte de cinco anos. A popula\u00e7\u00e3o de refer\u00eancia foi a da Amaz\u00f4nia brasileira. Elaborou-se um modelo de impacto or\u00e7ament\u00e1rio que foi validado por gestores e especialistas em mal\u00e1ria e assist\u00eancia farmac\u00eautica no SUS. O impacto or\u00e7ament\u00e1rio incremental foi de R$ 12,5 milh\u00f5es. O modelo previu que a incorpora\u00e7\u00e3o da tafenoquina reduziria os custos de hospitaliza\u00e7\u00e3o e de recorr\u00eancias em cerca de 9% e 11%, respectivamente. O custo e o desperd\u00edcio das tiras reagentes do teste impactaram nos resultados. As tecnologias avaliadas podem contribuir para a tomada de decis\u00f5es mais seguras no tratamento da mal\u00e1ria na Amaz\u00f4nia brasileira e parao planejamento, se as tecnologias em an\u00e1lise forem incorporadas.<\/jats:p>","DOI":"10.1590\/0102-311xpt044925","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T11:14:35Z","timestamp":1773659675000},"source":"Crossref","is-referenced-by-count":1,"title":["Amplia\u00e7\u00e3o do uso de tecnologias para redu\u00e7\u00e3o da mal\u00e1ria por Plasmodium vivax na Amaz\u00f4nia brasileira: uma an\u00e1lise de impacto or\u00e7ament\u00e1rio"],"prefix":"10.1590","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3861-5257","authenticated-orcid":false,"given":"M\u00e1rcia Gisele Santos da","family":"Costa","sequence":"first","affiliation":[{"name":"Instituto Nacional de Cardiologia,  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Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7568-5014","authenticated-orcid":false,"given":"M\u00e1rcia","family":"Pinto","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2026]]},"reference":[{"key":"ref1","series-title":"World malaria report 2020: 20 years of global progress and challenges","year":"2020"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"15","DOI":"10.4269\/ajtmh.16-0141","article-title":"Global epidemiology of Plasmodium vivax","volume":"95","author":"Howes RE","year":"2016","journal-title":"Am J Trop Med Hyg"},{"key":"ref3","series-title":"Guia de tratamento da mal\u00e1ria no Brasil.","year":"2021","edition":"2\u00aa"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/S2352-4642(21)00311-4","article-title":"Global, regional, and 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