{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:04:48Z","timestamp":1753887888383,"version":"3.41.2"},"reference-count":32,"publisher":"FapUNIFESP (SciELO)","issue":"3","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cad. Sa\u00fade P\u00fablica"],"abstract":"<jats:p>Resumo: Este estudo avaliou a associa\u00e7\u00e3o do peso ao nascer, idade gestacional e crescimento intrauterino com a densidade mineral \u00f3ssea (DMO) aos 22 e 30 anos, nas coortes de nascimentos de 1982 e 1993 de Pelotas, Rio Grande do Sul, Brasil. A DMO foi medida por absorciometria por raios X com dupla energia (DXA), a associa\u00e7\u00e3o foi avaliada usando an\u00e1lise de vari\u00e2ncia e a regress\u00e3o linear m\u00faltipla para o controle de confundimento por: sexo, renda familiar ao nascer, tabagismo materno na gesta\u00e7\u00e3o, escolaridade materna, cor da pele materna e \u00edndice de massa corporal pr\u00e9-gestacional. Foi testado se a gordura corporal na vida adulta era mediadora da associa\u00e7\u00e3o analisada, por meio da G-computation Formula. Foram avaliados 6.803 participantes das coortes de 1982 e 1993, aos 30 e 22 anos, respectivamente. O peso ao nascer teve associa\u00e7\u00e3o com a DMO em todos os s\u00edtios, com maior diferen\u00e7a no colo femoral. Os nascidos com menos de 2.000g apresentaram, em m\u00e9dia, -0,036g\/cm2 (IC95%: -0,064; -0,008) de DMO no colo femoral em compara\u00e7\u00e3o \u00e0queles com mais de 3.500g. Aqueles com escore-z de crescimento intrauterino com pelo menos 1,28 desvio padr\u00e3o abaixo da m\u00e9dia apresentaram, em m\u00e9dia, -0,013g\/cm2 (IC95%: -0,024; -0,002) de DMO na coluna lombar, em rela\u00e7\u00e3o aos com escore-z acima da m\u00e9dia. A an\u00e1lise de media\u00e7\u00e3o mostrou que gordura corporal na idade adulta n\u00e3o mediou a associa\u00e7\u00e3o. As condi\u00e7\u00f5es de nascimento foram associadas com a densidade mineral \u00f3ssea na vida adulta, e a identifica\u00e7\u00e3o dos fatores precoces relacionados \u00e0 perda de DMO \u00e9 essencial devido \u00e0 invers\u00e3o demogr\u00e1fica em progresso em pa\u00edses de m\u00e9dia e baixa renda.<\/jats:p>","DOI":"10.1590\/0102-311xpt085523","type":"journal-article","created":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T18:33:40Z","timestamp":1710268420000},"source":"Crossref","is-referenced-by-count":0,"title":["Associa\u00e7\u00e3o entre as condi\u00e7\u00f5es de nascimento e a densidade mineral \u00f3ssea de adultos das coortes de nascimentos de 1982 e 1993 de Pelotas, Rio Grande do Sul, Brasil"],"prefix":"10.1590","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6083-3678","authenticated-orcid":false,"given":"Lu\u00edsa Silveira da","family":"Silva","sequence":"first","affiliation":[{"name":"Universidade Federal de Pelotas,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4129-0898","authenticated-orcid":false,"given":"Ana Maria Baptista","family":"Menezes","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pelotas,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5973-1746","authenticated-orcid":false,"given":"Fernando C.","family":"Barros","sequence":"additional","affiliation":[{"name":"Universidade Cat\u00f3lica de Pelotas,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7137-1747","authenticated-orcid":false,"given":"Fernando C.","family":"Wehrmeister","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pelotas,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6470-3352","authenticated-orcid":false,"given":"Helen Denise Gon\u00e7alves da","family":"Silva","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pelotas,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9843-412X","authenticated-orcid":false,"given":"Bernardo Lessa","family":"Horta","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pelotas,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2024]]},"reference":[{"year":"2016","series-title":"Corpo humano: fundamentos de anatomia e fisiologia","author":"Tortora GJ","key":"ref1"},{"year":"2020","series-title":"Epidemiology of osteoporosis and fragility fractures","key":"ref2"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1002\/jbmr.2269","article-title":"The recent prevalence of osteoporosis and low bone mass in the United States based on bone mineral density at the femoral neck or lumbar 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