{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:17:33Z","timestamp":1787023053727,"version":"build-2736575974"},"reference-count":35,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cad. Sa\u00fade P\u00fablica"],"abstract":"<jats:p>Resumo: O objetivo foi analisar a tend\u00eancia temporal e o perfil cl\u00ednico-epidemiol\u00f3gico da coinfec\u00e7\u00e3o por leishmaniose visceral (LV) e HIV no Brasil entre 2009 e 2024. Estudo ecol\u00f3gico de s\u00e9rie temporal e transversal descritivo, baseado em dados do Sistema de Informa\u00e7\u00e3o de Agravos de Notifica\u00e7\u00e3o (SINAN) de oito estados com maior incid\u00eancia de LV: Bahia, Cear\u00e1, Maranh\u00e3o, Minas Gerais, Mato Grosso do Sul, Par\u00e1, S\u00e3o Paulo e Tocantins. As taxas anuais de coinfec\u00e7\u00e3o foram calculadas pela raz\u00e3o entre o n\u00famero de casos notificados de coinfec\u00e7\u00e3o LV\/HIV e a popula\u00e7\u00e3o residente no respectivo estado no mesmo ano, multiplicada por 100 mil. A tend\u00eancia temporal foi avaliada por regress\u00e3o segmentada, estimando a varia\u00e7\u00e3o percentual anual (APC, acr\u00f4nimo em ingl\u00eas). Realizaram-se an\u00e1lises de correla\u00e7\u00e3o (Spearman), associa\u00e7\u00f5es categ\u00f3ricas (qui-quadrado de Pearson), diferen\u00e7as de m\u00e9dias (t de Student) e regress\u00e3o log\u00edstica bin\u00e1ria (odds ratio - OR) para sintomas. Verificou-se tend\u00eancia crescente da taxa de coinfec\u00e7\u00e3o na Bahia (APC = 4,2), Mato Grosso do Sul (APC = 19,7), Par\u00e1 (APC = 10,4) e Tocantins (APC = 8,4). Cear\u00e1 e Minas Gerais apresentaram crescimento seguido de queda. Observou-se correla\u00e7\u00e3o positiva moderada entre casos de LV e coinfec\u00e7\u00e3o (\u03c1 = 0,313; p &lt; 0,001). Coinfectados tinham maior m\u00e9dia de idade (37,9 vs. 27,3 anos; p &lt; 0,001) e predom\u00ednio masculino (72,4% vs. 59,8%). A ra\u00e7a parda foi prevalente, com maior propor\u00e7\u00e3o de pretos entre os coinfectados. Sintomas associados \u00e0 coinfec\u00e7\u00e3o inclu\u00edram febre (OR = 2,44), icter\u00edcia (OR = 1,69) e edema (OR = 1,56); emagrecimento, hepatomegalia e infec\u00e7\u00e3o associada reduziram a chance. A coinfec\u00e7\u00e3o LV\/HIV apresenta padr\u00f5es heterog\u00eaneos, com tend\u00eancias crescentes nos estados end\u00eamicos e segmentos temporais distintos entre Unidades Federativas. Os achados refor\u00e7am a necessidade de estrat\u00e9gias integradas de vigil\u00e2ncia, diagn\u00f3stico e tratamento.<\/jats:p>","DOI":"10.1590\/0102-311xpt163425","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T11:01:04Z","timestamp":1783335664000},"source":"Crossref","is-referenced-by-count":1,"title":["Tend\u00eancia temporal e perfil cl\u00ednico-epidemiol\u00f3gico da coinfec\u00e7\u00e3o por leishmaniose visceral e HIV em estados brasileiros entre 2009 e 2024"],"prefix":"10.1590","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-2504-4702","authenticated-orcid":false,"given":"Marina","family":"Fran\u00e7a","sequence":"first","affiliation":[{"name":"Universidade Estadual do Mato Grosso do Sul,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9126-7162","authenticated-orcid":false,"given":"Mirella Ferreira da Cunha","family":"Santos","sequence":"additional","affiliation":[{"name":"Universidade Estadual do Mato Grosso do Sul,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4117-8030","authenticated-orcid":false,"given":"Juceli Gonzalez","family":"Gouveia","sequence":"additional","affiliation":[{"name":"Universidade Estadual do Mato Grosso do Sul,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9367-3893","authenticated-orcid":false,"given":"Leandro","family":"Antero","sequence":"additional","affiliation":[{"name":"Universidade Estadual do Mato Grosso do Sul,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2026]]},"reference":[{"key":"ref1","article-title":"Predictors of visceral leishmaniasis relapse in HIV-infected patients a systematic review","volume":"5","author":"Cota GF","year":"2011","journal-title":"PLOS Negl 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