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Sa\u00fade P\u00fablica"],"abstract":"<jats:p>A imunossenesc\u00eancia refere-se \u00e0s altera\u00e7\u00f5es do sistema imunol\u00f3gico com o envelhecimento, incluindo o aumento dos biomarcadores inflamat\u00f3rios, fen\u00f4meno conhecido como inflammaging, que est\u00e1 relacionado ao surgimento de doen\u00e7as associadas ao envelhecimento. O objetivo deste estudo foi descrever a distribui\u00e7\u00e3o de biomarcadores imunol\u00f3gicos nas cinco regi\u00f5es brasileiras e estimar as probabilidades preditas de suas concentra\u00e7\u00f5es nos tercis da distribui\u00e7\u00e3o, segundo as regi\u00f5es geogr\u00e1ficas. Amostras sorol\u00f3gicas de 2.111 participantes (\u2265 50 anos) coletadas na linha de base (2015\/2016) do ELSI-Brasil foram analisadas. As regi\u00f5es geogr\u00e1ficas (Norte, Nordeste, Centro-oeste, Sudeste e Sul) foram a exposi\u00e7\u00e3o de interesse do estudo, e os potenciais fatores de confus\u00e3o inclu\u00edram idade, sexo, n\u00edvel educacional, \u00e1rea de resid\u00eancia, consumo de \u00e1lcool e tabaco, atividade f\u00edsica e autodeclara\u00e7\u00e3o de diagn\u00f3sticos m\u00e9dicos de hipertens\u00e3o, diabetes, asma, artrite e c\u00e2ncer. As probabilidades preditas das concentra\u00e7\u00f5es dos biomarcadores em cada tercil foram estimadas a partir de modelos de regress\u00e3o log\u00edstica multinomial, ajustados pelos confundidores. Notou-se uma maior probabilidade de as regi\u00f5es Norte e Nordeste apresentarem n\u00edveis s\u00e9ricos mais altos, enquanto a Regi\u00e3o Centro-oeste n\u00edveis mais baixos, sugerindo diferen\u00e7as na imunobiografia que podem ser resultado de exposi\u00e7\u00f5es ambientais, socioecon\u00f4micas e infecciosas distintas ao longo da vida. No entanto, as raz\u00f5es para essas diferen\u00e7as ainda n\u00e3o foram elucidadas e precisam ser investigadas em estudos posteriores.<\/jats:p>","DOI":"10.1590\/0102-311xpt172124","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T11:33:01Z","timestamp":1780054381000},"source":"Crossref","is-referenced-by-count":0,"title":["Avalia\u00e7\u00e3o do perfil imunol\u00f3gico de adultos mais velhos segundo as regi\u00f5es brasileiras: resultados do ELSI-Brasil"],"prefix":"10.1590","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1752-6266","authenticated-orcid":false,"given":"Maria Luiza","family":"Lima-Silva","sequence":"first","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz,  Brazil; Universidade Federal de Minas Gerais,  Brazil; Funda\u00e7\u00e3o Oswaldo Cruz,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0420-3062","authenticated-orcid":false,"given":"Juliana Vaz de Melo","family":"Mambrini","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz,  Brazil; Universidade Federal de Minas Gerais,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2943-4350","authenticated-orcid":false,"given":"Karen Cec\u00edlia de Lima","family":"Torres","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz,  Brazil; Universidade Federal de Minas Gerais,  Brazil; Funda\u00e7\u00e3o Oswaldo Cruz,  Brazil; Universidade Edson Ant\u00f4nio Velano,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5494-4889","authenticated-orcid":false,"given":"Olindo Assis","family":"Martins-Filho","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz,  Brazil; Funda\u00e7\u00e3o Oswaldo Cruz,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2814-5183","authenticated-orcid":false,"given":"Andr\u00e9a","family":"Teixeira-Carvalho","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz,  Brazil; Funda\u00e7\u00e3o Oswaldo Cruz,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1077-1381","authenticated-orcid":false,"given":"Maria Fernanda","family":"Lima-Costa","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz,  Brazil; Universidade Federal de Minas Gerais,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9431-2280","authenticated-orcid":false,"given":"S\u00e9rgio Viana","family":"Peixoto","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz,  Brazil; Universidade Federal de Minas Gerais,  Brazil; Universidade Federal de Minas Gerais,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2026]]},"reference":[{"key":"ref1","first-page":"4","article-title":"Age and immunity what is \"immunosenescence\"? 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