{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:03:30Z","timestamp":1791198210847,"version":"4.1.0"},"reference-count":34,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Minist\u00e9rio da Sa\u00fade","award":["001"],"award-info":[{"award-number":["001"]}]},{"name":"Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","award":["001"],"award-info":[{"award-number":["001"]}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"https:\/\/ror.org\/00x0ma614","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cad. Sa\u00fade P\u00fablica"],"abstract":"<jats:p>Resumo: O desconforto respirat\u00f3rio neonatal constitui condi\u00e7\u00e3o de elevada gravidade cl\u00ednica e carga econ\u00f4mica para o Sistema \u00danico de Sa\u00fade. Este estudo estimou os custos diretos das interna\u00e7\u00f5es entre 2018 e 2021 e descreveu sua distribui\u00e7\u00e3o por diagn\u00f3stico, regi\u00e3o e per\u00edodo. Realizou-se um estudo de custo de doen\u00e7a, abordagem top-down, com autoriza\u00e7\u00f5es de interna\u00e7\u00e3o hospitalar de rec\u00e9m-nascidos de 0 a 27 dias. Os valores foram atualizados para dezembro de 2025 e padronizados por mil nascidos vivos. No per\u00edodo, ocorreram 1.449.694 interna\u00e7\u00f5es neonatais, das quais, 227.130 (15,7%) foram por desconforto respirat\u00f3rio; cerca de metade foi classificada como \u201cn\u00e3o especificada\u201d pela Classifica\u00e7\u00e3o Internacional de Doen\u00e7as, 10\u00aa revis\u00e3o. O gasto total aproximou-se de 1,4 bilh\u00e3o de Reais, sendo 69,6% referentes ao cuidado em unidades de terapia intensiva neonatal. O custo por mil nascidos vivos variou de R$ 111.625 na Regi\u00e3o Norte a R$ 769.847 na Regi\u00e3o Sul. A s\u00edndrome do desconforto respirat\u00f3rio apresentou a maior mediana de custo por interna\u00e7\u00e3o (R$ 8.060). Registrou-se redu\u00e7\u00e3o das admiss\u00f5es por s\u00edndrome do desconforto respirat\u00f3rio e aumento por taquipneia transit\u00f3ria, outros desconfortos e diagn\u00f3sticos n\u00e3o especificados, com queda nas medianas de custo no per\u00edodo. Entre 2020 e 2021, observou-se maior uso de leitos de terapia intensiva neonatal e aumento da mortalidade proporcional nos casos classificados como \u201cn\u00e3o especificados\u201d. A carga econ\u00f4mica \u00e9 elevada e heterog\u00eanea entre as regi\u00f5es. As estimativas por diagn\u00f3stico e regi\u00e3o orientam o planejamento da capacidade de terapia intensiva neonatal e pol\u00edticas de equidade na aten\u00e7\u00e3o perinatal.<\/jats:p>","DOI":"10.1590\/0102-311xpt220625","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:40:22Z","timestamp":1791196822000},"source":"Crossref","is-referenced-by-count":0,"title":["Qual o custo hospitalar do desconforto respirat\u00f3rio neonatal para o Sistema \u00danico de Sa\u00fade? An\u00e1lise nacional dos custos diretos, distribui\u00e7\u00e3o regional e varia\u00e7\u00e3o temporal"],"prefix":"10.1590","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-9768-887X","authenticated-orcid":false,"given":"Let\u00edcia Araujo","family":"Villarinho","sequence":"first","affiliation":[{"name":"Universidade de Bras\u00edlia","place":["Bras\u00edlia, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1592-6004","authenticated-orcid":false,"given":"Julia Raffin","family":"Moura","sequence":"additional","affiliation":[{"name":"Universidade de Bras\u00edlia","place":["Bras\u00edlia, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5736-1729","authenticated-orcid":false,"given":"Mchilanny Bussinguer de","family":"Menezes","sequence":"additional","affiliation":[{"name":"Universidade de Bras\u00edlia","place":["Bras\u00edlia, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0355-9363","authenticated-orcid":false,"given":"Emilie Freire","family":"Batista","sequence":"additional","affiliation":[{"name":"Universidade de Bras\u00edlia","place":["Bras\u00edlia, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6226-2837","authenticated-orcid":false,"given":"Silvana Alves","family":"Pereira","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Norte","place":["Natal, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0041-0750","authenticated-orcid":false,"given":"Aline Martins de","family":"Toledo","sequence":"additional","affiliation":[{"name":"Universidade de Bras\u00edlia","place":["Bras\u00edlia, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2026]]},"reference":[{"key":"ref1","series-title":"Neonatal mortality - 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