{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T05:14:12Z","timestamp":1793423652105,"version":"4.5.0"},"reference-count":45,"publisher":"FapUNIFESP (SciELO)","issue":"6","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cad. Sa\u00fade P\u00fablica"],"abstract":"<jats:p>Resumo: A restri\u00e7\u00e3o do crescimento intrauterino e a prematuridade determinam o baixo peso ao nascer, e a combina\u00e7\u00e3o das tr\u00eas condi\u00e7\u00f5es resulta em diferentes fen\u00f3tipos neonatais que interferem na sobreviv\u00eancia infantil. Foram estimadas a preval\u00eancia, a sobreviv\u00eancia e a mortalidade neonatal, segundo os fen\u00f3tipos neonatais, na coorte de nascidos vivos de 2021 no Rio de Janeiro, Brasil. Foram exclu\u00eddos nascidos vivos de gravidez m\u00faltipla, com anomalia cong\u00eanita, e com inconsist\u00eancias nas informa\u00e7\u00f5es de peso e idade gestacional. Foi utilizada a curva Intergrowth para classificar adequa\u00e7\u00e3o do peso, e estimadas a mortalidade (&lt; 24 horas, 1-6 e 7-27 dias) e sobrevida (Kaplan-Meier). Dos 174.399 nascidos vivos, 6,8%, 5,5% e 9,5% eram, respectivamente, baixo peso ao nascer, pequeno para idade gestacional (PIG) e prematuros. Entre nascidos vivos com baixo peso ao nascer, 39,7% eram PIG e 70%, prematuros. Os fen\u00f3tipos neonatais foram heterog\u00eaneos segundo caracter\u00edsticas maternas, do parto, da gesta\u00e7\u00e3o e do rec\u00e9m-nascido. A taxa de mortalidade por 1.000 nascidos vivos foi elevada para neonatos de baixo peso ao nascer prematuros, tanto PIG (78,1) quanto AIG (adequado para idade gestacional: 61,1), em todas as idades espec\u00edficas. Houve redu\u00e7\u00f5es significantes da sobrevida quando comparados aos nascidos vivos n\u00e3o baixo peso ao nascer, AIG termo. As preval\u00eancias estimadas mostraram menores valores que as de outros estudos, em parte pelos crit\u00e9rios de exclus\u00e3o adotados. Os fen\u00f3tipos neonatais identificaram crian\u00e7as mais vulner\u00e1veis e com maior risco de morte. A prematuridade contribuiu mais para a mortalidade que a condi\u00e7\u00e3o de PIG; sua preven\u00e7\u00e3o \u00e9 necess\u00e1ria para reduzir a mortalidade neonatal no Estado do Rio de Janeiro.<\/jats:p>","DOI":"10.1590\/0102-311xpt231022","type":"journal-article","created":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T07:38:01Z","timestamp":1687765081000},"source":"Crossref","is-referenced-by-count":10,"title":["Restri\u00e7\u00e3o do crescimento intrauterino, prematuridade e baixo peso ao nascer: fen\u00f3tipos de risco de morte neonatal, Estado do Rio de Janeiro, Brasil"],"prefix":"10.1590","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5439-9158","authenticated-orcid":false,"given":"Pauline Lorena","family":"Kale","sequence":"first","affiliation":[{"name":"Universidade Federal do Rio de Janeiro,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5493-494X","authenticated-orcid":false,"given":"Sandra Costa","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Universidade Federal Fluminense,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2023]]},"reference":[{"key":"ref1","series-title":"Every child alive: the urgent need to end newborn deaths.","year":"2018"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1186\/s12884-017-1464-8","article-title":"Quality of perinatal care services from the user&apos;s perspective: a Dutch study applies the World Health Organization's responsiveness concept.","volume":"17","author":"van der Kooy J","year":"2017","journal-title":"BMC Pregnancy Childbirth"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1186\/s12889-020-08925-w","article-title":"Decreasing trend in preterm birth and perinatal mortality, do disparities also decline?","volume":"20","author":"Ravelli ACJ","year":"2020","journal-title":"BMC Public Health"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/S0140-6736(20)31906-1","article-title":"The Lancet small vulnerable newborn series science for a healthy start","volume":"396","author":"Ashorn P","year":"2020","journal-title":"Lancet"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1001\/jamapediatrics.2022.1622","article-title":"Global, regional, and national incidence and mortality of neonatal preterm birth, 1990-2019","volume":"176","author":"Cao G","year":"2022","journal-title":"JAMA Pediatr"},{"key":"ref6","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0172533","article-title":"Infant mortality, and morbidity associated with preterm and small-for-gestational-age births in Southern Mozambique a retrospective cohort study","volume":"12","author":"Garcia-Basteiro AL","year":"2017","journal-title":"PLoS One"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.jpeds.2017.09.007","article-title":"Neonatal and infant mortality risk associated with preterm and small for gestational age births in Tanzania: individual level pooled analysis using the Intergrowth standard.","volume":"192","author":"Sania A","year":"2018","journal-title":"J Pediatr"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"j3677","DOI":"10.1136\/bmj.j3677","article-title":"Estimates of burden and consequences of infants born small for gestational age in low- and middle-income countries with INTERGROWTH-21st standard analysis of CHERG datasets","volume":"358","author":"Lee AC","year":"2017","journal-title":"BMJ"},{"key":"ref9","first-page":"100045","article-title":"Risk of mortality for small newborns in Brazil, 2011-2018: a national birth cohort study of 17.6 million records from routine register-based linked data.","volume":"3","author":"Paix\u00e3o ES","year":"2021","journal-title":"Lancet Reg Health Am"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"e849","DOI":"10.1016\/S2214-109X(18)30565-5","article-title":"National, regional, and worldwide estimates of low birthweight in 2015, with trends from 2000: a systematic analysis.","volume":"7","author":"Blencowe H","year":"2019","journal-title":"Lancet Glob Health"},{"key":"ref11","series-title":"UNICEF-WHO low birthweight estimates: levels and trends 2000-2015","year":"2019"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"e37","DOI":"10.1016\/S2214-109X(18)30451-0","article-title":"Global, regional, and national estimates of levels of preterm birth in 2014: a systematic review and modelling analysis.","volume":"7","author":"Chawanpaiboon S","year":"2019","journal-title":"Lancet Glob Health"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1001\/jamapediatrics.2021.1050","article-title":"Maternal and neonatal morbidity and mortality among pregnant women with and without COVID-19 infection the INTERCOVID Multinational Cohort Study","volume":"175","author":"Villar J","year":"2021","journal-title":"JAMA Pediatr"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1186\/s12884-021-04156-y","article-title":"The impact of COVID-19 first wave national lockdowns on perinatal outcomes a rapid review and meta-analysis","volume":"21","author":"Vaccaro C","year":"2021","journal-title":"BMC Pregnancy Childbirth"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"14725","DOI":"10.1038\/s41598-020-71252-y","article-title":"Risk stratification for small for gestational age for the Brazilian population a secondary analysis of the Birth in Brazil study","volume":"10","author":"Souza RT","year":"2020","journal-title":"Sci Rep"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1093\/ajcn\/nqab033","article-title":"Factors associated with small- and large-for-gestational-age in socioeconomically vulnerable individuals in the 100 Million Brazilian Cohort","volume":"114","author":"Falc\u00e3o IR","year":"2021","journal-title":"Am J Clin Nutr"},{"key":"ref17","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2018-021538","article-title":"Caesarean sections and the prevalence of preterm and early-term births in Brazil secondary analyses of national birth registration","volume":"8","author":"Barros FC","year":"2018","journal-title":"BMJ Open"},{"key":"ref18","article-title":"Mortalidade neonatal espec\u00edfica por idade e fatores associados na coorte de nascidos vivos em 2021, no estado do Rio de Janeiro, Brasil","volume":"25","author":"Kale PL","year":"2022","journal-title":"Rev Bras Epidemiol"},{"key":"ref19","article-title":"Near miss e mortalidade neonatal e fatores associados estudo de coorte de nascimentos do munic\u00edpio do Rio de Janeiro, RJ. 2021","volume":"41","author":"Rocha NM","year":"2023","journal-title":"Rev Paul Pediatr"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"205","DOI":"10.3389\/fendo.2020.00205","article-title":"Editorial causes and consequences of intrauterine growth restriction","volume":"11","author":"Bendix I","year":"2020","journal-title":"Front Endocrinol (Lausanne)"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1007\/s10654-021-00810-z","article-title":"The limits of small-for-gestational-age as a high-risk category","volume":"36","author":"Wilcox AJ","year":"2021","journal-title":"Eur J Epidemiol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/S0140-6736(14)60932-6","article-title":"International standards for newborn weight, length, and head circumference by gestational age and sex the Newborn Cross-Sectional Study of the INTERGROWTH-21st Project","volume":"384","author":"Villar J","year":"2014","journal-title":"Lancet"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/S0140-6736(16)00384-6","article-title":"INTERGROWTH-21st very preterm size at birth reference charts","volume":"387","author":"Villar J","year":"2016","journal-title":"Lancet"},{"key":"ref24","series-title":"Epidemiology.","first-page":"116","volume-title":"The natural history of disease: ways of expressing the prognosis.","author":"Gordis L","year":"2014","edition":"5th Ed"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1038\/s41598-017-00941-y","article-title":"Maternal lipids and leptin concentrations are associated with large-for-gestational-age births: a prospective cohort study.","volume":"7","author":"Farias DR","year":"2017","journal-title":"Sci Rep"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1590\/S0034-89102011005000019","article-title":"How many low birthweight babies in low- and middle-income countries are preterm","volume":"45","author":"Barros FC","year":"2011","journal-title":"Rev Sa\u00fade P\u00fablica"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"2141S","DOI":"10.3945\/jn.117.247767","article-title":"New option in the Lives Saved Tool (LiST) allows for the conversion of prevalence of small-for-gestational-age and preterm births to prevalence of low birth weight","volume":"147","author":"Kozuki N","year":"2017","journal-title":"J Nutr"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/s12884-023-05411-0","article-title":"Influence of different methods for calculating gestational age at birth on prematurity and small for gestational age proportions a systematic review with meta-analysis","volume":"23","author":"Vitral GLN","year":"2023","journal-title":"BMC Pregnancy Childbirth"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.bpobgyn.2018.02.002","article-title":"Building consensus and standards in fetal growth restriction studies","volume":"49","author":"Gordijn SJ","year":"2018","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"ref30","article-title":"Differences when classifying small for gestational age preterm infants according to the growth chart applied.","author":"Esta\u00f1-Capell J","year":"2023","journal-title":"Am J Perinatol"},{"key":"ref31","article-title":"Congenital anomalies in Rio Grande do Sul State a time series analysis","volume":"22","author":"Luz GDS","year":"2019","journal-title":"Rev Bras Epidemiol"},{"key":"ref32","article-title":"Congenital anomalies in Santa Catarina case distribution and trends in 2010-2018","volume":"40","author":"Vanassi BM","year":"2021","journal-title":"Rev Paul Pediatr"},{"key":"ref33","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0245152","article-title":"Twin pregnancy and perinatal outcomes: data from \"Birth in Brazil Study\".","volume":"16","author":"Esteves-Pereira AP","year":"2021","journal-title":"PLoS One"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.siny.2018.09.001","article-title":"Epidemiology of late preterm and early term births an international perspective","volume":"24","author":"Delnord M","year":"2019","journal-title":"Semin Fetal Neonatal Med"},{"key":"ref35","article-title":"Mediating roles of preterm birth and restricted fetal growth in the relationship between maternal education and infant mortality a Danish population-based cohort study","volume":"16","author":"Yu Y","year":"2019","journal-title":"PLoS Med"},{"key":"ref36","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0276291","article-title":"Survival status and predictors of mortality among low-birthweight neonates admitted to KMC units of five public hospitals in Ethiopia frailty survival regression model","volume":"17","author":"Debere MK","year":"2022","journal-title":"PLoS One"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/s12884-016-0900-5","article-title":"Risk factors for small-for-gestational-age and preterm births among 19,269 Tanzanian newborns","volume":"16","author":"Muhihi A","year":"2016","journal-title":"BMC Pregnancy Childbirth"},{"key":"ref38","article-title":"Risk factors and adverse perinatal outcomes among term and preterm infants born small-for-gestational-age secondary analyses of the WHO Multi-Country Survey on Maternal and Newborn Health","volume":"9","author":"Ota E","year":"2014","journal-title":"PLoS One"},{"key":"ref39","doi-asserted-by":"crossref","DOI":"10.1590\/0102-311x00214918","article-title":"Avalia\u00e7\u00e3o das informa\u00e7\u00f5es do Sistema de Informa\u00e7\u00f5es sobre Nascidos Vivos (SINASC), Brasil","volume":"35","author":"Szwarcwald CL","year":"2019","journal-title":"Cad Sa\u00fade P\u00fablica"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1590\/1414-462x201800040400","article-title":"Adequa\u00e7\u00e3o do peso ao nascer para idade gestacional de acordo com a curva INTERGROWTH-21ste fatores associados ao pequeno para idade gestacional","volume":"26","author":"Kale PL","year":"2018","journal-title":"Cad Sa\u00fade Colet (Rio J.)"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"100167","DOI":"10.1016\/j.lanepe.2021.100167","article-title":"International versus national growth charts for identifying small and large-for-gestational age newborns a population-based study in 15 European countries","volume":"8","author":"Hocquette A","year":"2021","journal-title":"Lancet Reg Health Eur"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1002\/uog.22151","article-title":"Performance of six birthweight and estimated-fetal-weight standards for predicting adverse perinatal outcome a 10-year nationwide population-based study","volume":"58","author":"Choi SKY","year":"2021","journal-title":"Ultrasound Obstet Gynecol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.jped.2022.07.007","article-title":"Growth phenotypes of very low birth weight infants for prediction of neonatal outcomes from a Brazilian cohort comparison with INTERGROWTH","volume":"99","author":"Cardoso VC","year":"2023","journal-title":"J Pediatr (Rio J.)"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"179","DOI":"10.3389\/fendo.2019.00179","article-title":"Hormonal changes associated with intra-uterine growth restriction impact on the developing brain and future neurodevelopment","volume":"10","author":"Baud O","year":"2019","journal-title":"Front Endocrinol (Lausanne)"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1015622","DOI":"10.3389\/fendo.2022.1015622","article-title":"Spontaneous preterm birth: Involvement of multiple feto-maternal tissues and organ 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