{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:37:38Z","timestamp":1792687058917,"version":"4.5.0"},"reference-count":28,"publisher":"FapUNIFESP (SciELO)","issue":"9","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cad. Sa\u00fade P\u00fablica"],"abstract":"<jats:p>As perdas na cascata de cuidados do tratamento preventivo da tuberculose (TB) em pessoas vivendo com HIV\/aids (PVHIV) s\u00e3o frequentes, desde a identifica\u00e7\u00e3o de indiv\u00edduos em risco at\u00e9 a conclus\u00e3o do tratamento. Este estudo analisou os fatores associados \u00e0 conclus\u00e3o do tratamento preventivo da TB e o efeito do esquema 3HP na ocorr\u00eancia desse desfecho nas PVHIV entre 2021 e 2023 no Brasil. Conduziu-se uma coorte retrospectiva com dados secund\u00e1rios do Sistema de Informa\u00e7\u00e3o para Notifica\u00e7\u00e3o das Pessoas em Tratamento da Infec\u00e7\u00e3o Latente pelo Mycobacterium tuberculosis (IL-TB). Incluiu\u00ed-se as PVHIV com 18 anos ou mais, independentemente da contagem de c\u00e9lulas linf\u00f3citos T-CD4+, notificadas no IL-TB como caso novo ou reexposi\u00e7\u00e3o. A conclus\u00e3o do tratamento preventivo da TB foi o desfecho. Empregou-se regress\u00e3o de Poisson com vari\u00e2ncia robusta para calcular o risco relativo de completar o tratamento preventivo da TB, com intervalo de 95% de confian\u00e7a. Estimou-se o efeito m\u00e9dio do esquema 3HP na conclus\u00e3o do tratamento preventivo da TB, ponderado por um escore de propens\u00e3o. Incluiu-se 15.171 PVHIV, sendo que 11.546 (76%) completaram o tratamento preventivo da TB. A conclus\u00e3o do tratamento preventivo da TB foi maior em indiv\u00edduos com idade \u2265 60 anos, com prova tubercul\u00ednica \u2265 5mm e que utilizaram o esquema 3HP. O esquema 3HP demonstrou um efeito m\u00e9dio de aumentar em 11% a conclus\u00e3o do tratamento preventivo da TB. Os resultados evidenciam o efeito positivo do 3HP na conclus\u00e3o do tratamento preventivo da TB em PVHIV, em compara\u00e7\u00e3o com os esquemas de monoterapia com rifampicina ou isoniazida, o que sugere o potencial do 3HP para otimizar as estrat\u00e9gias de preven\u00e7\u00e3o da TB em PVHIV.<\/jats:p>","DOI":"10.1590\/0102-311xpt231024","type":"journal-article","created":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T15:07:23Z","timestamp":1759504043000},"source":"Crossref","is-referenced-by-count":1,"title":["Efeito do esquema 3HP na conclus\u00e3o do tratamento preventivo da tuberculose em pessoas que vivem com HIV: uma coorte retrospectiva no Brasil"],"prefix":"10.1590","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4972-4686","authenticated-orcid":false,"given":"Jo\u00e3o Paulo","family":"Cola","sequence":"first","affiliation":[{"name":"Universidade Federal do Esp\u00edrito Santo,  Brazil; Faculdade MULTIVIX de S\u00e3o Mateus,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4057-5908","authenticated-orcid":false,"given":"Gustavo Silva dos","family":"Santos","sequence":"additional","affiliation":[{"name":"Faculdade MULTIVIX de S\u00e3o Mateus,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2093-8816","authenticated-orcid":false,"given":"Fernanda Mattos de","family":"Souza","sequence":"additional","affiliation":[{"name":"Universidade Federal do Esp\u00edrito Santo,  Brazil; Universidade Federal do Rio de Janeiro,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2879-5621","authenticated-orcid":false,"given":"Carolina Maia Martins","family":"Sales","sequence":"additional","affiliation":[{"name":"Universidade Federal do Esp\u00edrito Santo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7654-2402","authenticated-orcid":false,"given":"Heriederson S\u00e1vio Dias","family":"Moura","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4792-8714","authenticated-orcid":false,"given":"Ricardo Alexandre","family":"Arc\u00eancio","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4826-3355","authenticated-orcid":false,"given":"Ethel Leonor Noia","family":"Maciel","sequence":"additional","affiliation":[{"name":"Universidade Federal do Esp\u00edrito Santo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8132-6288","authenticated-orcid":false,"given":"Thiago Nascimento do","family":"Prado","sequence":"additional","affiliation":[{"name":"Universidade Federal do Espirito Santo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2025]]},"reference":[{"key":"ref1","series-title":"Global tuberculosis report 2024","year":"2024"},{"key":"ref2","article-title":"Diagnosis and treatment of tuberculosis in adults with HIV","volume":"101","author":"Yang Q","year":"2022","journal-title":"Medicine"},{"key":"ref3","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1003738","article-title":"Tuberculosis preventive therapy for people living with HIV a systematic review and network meta-analysis","volume":"18","author":"Yanes-Lane M","year":"2021","journal-title":"PLoS Med"},{"key":"ref4","series-title":"Protocolo de vigil\u00e2ncia da infec\u00e7\u00e3o latente pelo Mycobacterium tuberculosis no Brasil.","year":"2022","edition":"2\u00aa"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1289298","DOI":"10.3389\/fmed.2023.1289298","article-title":"The incorporation of the 3HP regimen for tuberculosis preventive treatment in the Brazilian health system a secondary-database nationwide analysis","volume":"5","author":"Mendes LVP","year":"2024","journal-title":"Front Med"},{"issue":"n\u00famero especial","key":"ref6","article-title":"Tuberculose 2024.","year":"2024","journal-title":"Boletim Epidemiol\u00f3gico"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"215","DOI":"10.5588\/ijtld.22.0571","article-title":"Factors associated with non-completion of TB preventive treatment in Brazil.","volume":"27","author":"Cola JP","year":"2023","journal-title":"Int J Tuberc Lung Dis"},{"key":"ref8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1003703","article-title":"The latent tuberculosis cascade-of-care among people living with HIV a systematic review and meta-analysis","volume":"18","author":"Bastos ML","year":"2021","journal-title":"PLoS Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1080\/00273171.2011.568786","article-title":"An introduction to propensity score methods for reducing the effects of confounding in observational studies","volume":"46","author":"Austin PC","year":"2011","journal-title":"Multivariate Behav Res"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1080\/01621459.2016.1260466","article-title":"Balancing covariates via propensity score weighting","volume":"113","author":"Li F","year":"2018","journal-title":"J Am Stat Assoc"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1177\/0193841X08317586","article-title":"Weighting regressions by propensity scores","volume":"32","author":"Freedman D","year":"2008","journal-title":"Eval Rev"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1056\/NEJMoa1806808","article-title":"One month of rifapentine plus isoniazid to prevent HIV-related tuberculosis","volume":"380","author":"Swindells S","year":"2019","journal-title":"N Engl J Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"404","DOI":"10.5588\/ijtldopen.23.0609","article-title":"Three months of weekly rifapentine plus isoniazid for TB prevention among people with HIV","volume":"1","author":"Borse R","year":"2024","journal-title":"IJTLD Open"},{"key":"ref14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1003875","article-title":"Completion of isoniazid-rifapentine (3HP) for tuberculosis prevention among people living with HIV interim analysis of a hybrid type 3 effectiveness-implementation randomized trial","volume":"18","author":"Semitala FC","year":"2021","journal-title":"PLoS 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Resp Med"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/S2214-109X(23)00251-6","article-title":"Impact and cost-effectiveness of short-course tuberculosis preventive treatment for household contacts and people with HIV in 29 high-incidence countries a modelling analysis","volume":"11","author":"Ryckman T","year":"2023","journal-title":"Lancet Glob Health"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1016\/S2214-109X(24)00221-3","article-title":"Cost-effectiveness and health impact of screening and treatment of Mycobacterium tuberculosis infection among formerly incarcerated individuals in Brazil: a Markov modelling study.","volume":"12","author":"Titan AVL","year":"2024","journal-title":"Lancet Glob Health"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1186\/s12879-017-2377-x","article-title":"Efficacy and completion rates of rifapentine and isoniazid (3HP) compared to other treatment regimens 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Infect"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41533-020-0179-x","article-title":"Interventions to improve medication adherence in tuberculosis patients a systematic review of randomized controlled studies","volume":"30","author":"Pradipta IS","year":"2020","journal-title":"NPJ Prim Care Respir Med"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1186\/s12879-024-09417-7","article-title":"Predictors of unsuccessful tuberculosis treatment outcomes in Brazil: an analysis of 259,484 patient records.","volume":"24","author":"Ryuk DK","year":"2024","journal-title":"BMC Infec Dis"},{"key":"ref25","article-title":"Factors associated with unsuccessful tuberculosis treatment among homeless persons in Brazil a retrospective cohort study from 2015 to 2020","volume":"17","author":"Rodrigues OAS","year":"2023","journal-title":"PLoS Negl Trop Dis"},{"key":"ref26","article-title":"Fatores associados aos desfechos desfavor\u00e1veis de 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