{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T12:26:45Z","timestamp":1784723205750,"version":"3.55.0"},"reference-count":30,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ABCD, arq. bras. cir. dig."],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:p>ABSTRACT  Background:  Although the incidence of gastric (adenocarcinoma) cancer has been decreasing over time, it is still one of the most common malignancies worldwide, and proximal tumours tend to have a worse prognosis.  Aim:  To compare surgical outcomes and prognosis between proximal - excluding tumours of the cardia - and distal gastric cancer.  Methods:  Out of 293 cases reviewed - 209 with distal and 69 with proximal gastric cancer - were compared for clinical and pathological features, stage, surgical outcome, mortality and survival.  Results:  Statistically, there was no significant difference between patients in both groups regarding mortality (p=0.661), adjuvant chemotherapy (p 0.661), and radiation (p=1.000). However, there was significant difference in the degree of lymph node dissection employed (p=0.002) and the number of positive lymph nodes resected (p=0.038) between the two groups. The odds of death at five years for patients who had a D0 dissection was three times greater (odds ratio 2.78; (95%CI 1.33-5.82) than that for patients who had a D2 dissection, while for patients who had a D1 dissection the odds ratio was only 1.41 (95%CI 0.71-2.83) compared to D2-dissected patients.  Conclusion:  Although no significant differences were found between proximal and distal gastric cancer, the increased risk of death in D0- and D1-dissected patients clearly suggests an important role of radical D2 lymph node dissection in survival.<\/jats:p>","DOI":"10.1590\/0102-6720201600040005","type":"journal-article","created":{"date-parts":[[2017,1,7]],"date-time":"2017-01-07T16:24:14Z","timestamp":1483806254000},"page":"232-235","source":"Crossref","is-referenced-by-count":12,"title":["DO PROXIMAL AND DISTAL GASTRIC TUMOURS BEHAVE DIFFERENTLY?"],"prefix":"10.1590","volume":"29","author":[{"given":"Laurence Bedin da","family":"COSTA","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Universidade Federal do Rio Grande do Sul,  Brazil","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo Garcia","family":"TONETO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Fernando","family":"MOREIRA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul,  Brazil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Hospital de Cl\u00ednicas de Porto Alegre,  Brazil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"issue":"1","key":"ref1","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1002\/1096-9098(200005)74:1<33::AID-JSO8>3.0.CO;2-R","article-title":"Clinicopathologic findings and results of surgical treatment in cardiac adenocarcinoma","volume":"74","author":"Bruno L","year":"2000","journal-title":"J Surg Oncol"},{"issue":"2","key":"ref2","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1002\/jso.20244","article-title":"Extended multiorgan resection for T4 gastric carcinoma 25-year experience","volume":"90","author":"Carboni F1","year":"2005","journal-title":"J Surg Oncol"},{"issue":"2","key":"ref3","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1007\/s10120-011-0024-6","article-title":"The effectiveness of the new (7th) UICC N classification in the prognosis evaluation of gastric cancer patients a comparative study between the 5th\/6th and 7th UICC N classification","volume":"14","author":"Chae S","year":"2011","journal-title":"Gastric Cancer"},{"issue":"2","key":"ref4","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1097\/SLA.0b013e3181b13ca2","article-title":"The Clavien-Dindo classification of surgical complications five-year experience","volume":"250","author":"Clavien PA","year":"2009","journal-title":"Ann Surg"},{"issue":"1","key":"ref5","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1056\/NEJMoa055531","article-title":"Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer","volume":"355","author":"Cunningham D","year":"2006","journal-title":"N Engl J Med"},{"issue":"5","key":"ref6","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1245\/s10434-010-0939-x","article-title":"Suitability of 7th UICC N stage for predicting the overall survival of gastric cancer patients after curative resection in China","volume":"17","author":"Deng J","year":"2010","journal-title":"Ann Surg Oncol"},{"key":"ref7","series-title":"AJCC cancer staging manual","author":"Edge SB","year":"2010"},{"key":"ref8","series-title":"GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11","author":"Ferlay J","year":"2013"},{"issue":"4","key":"ref9","first-page":"531","article-title":"Maximum gastric cancer diameter as a prognostic indicator univariate and multivariate analysis","volume":"22","author":"Giuliani A","year":"2003","journal-title":"J Exp Clin Cancer Res"},{"key":"ref10","series-title":"[National Institute of Cancer] 2014 estimates: incidence of cancer in Brazil [Internet]","author":"Gomes da Silva JA","year":"2014"},{"issue":"7","key":"ref11","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1093\/jnci\/djn517","article-title":"The impact of underreported Veterans Affairs data on national cancer statistics analysis using population-based SEER registries","volume":"101","author":"Howlader N","year":"2009","journal-title":"J Natl Cancer Inst"},{"issue":"2","key":"ref12","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1007\/s10120-011-0041-5","article-title":"Japanese classification of gastric carcinoma 3rd English edition","volume":"14","year":"2011","journal-title":"Gastric Cancer"},{"issue":"5-6","key":"ref13","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1159\/000097895","article-title":"Clinicopathological characteristics and prognosis of carcinoma of the gastric cardia","volume":"23","author":"Kim DY","year":"2006","journal-title":"Dig Surg"},{"issue":"1","key":"ref14","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.jamcollsurg.2004.09.015","article-title":"Surgical outcomes for early gastric cancer in the upper third of the stomach","volume":"200","author":"Kunisaki C","year":"2005","journal-title":"J Am Coll Surg"},{"issue":"2","key":"ref15","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.jamcollsurg.2005.10.020","article-title":"Surgical outcomes in patients with T4 gastric carcinoma","volume":"202","author":"Kunisaki C","year":"2006","journal-title":"J Am Coll Surg"},{"issue":"7","key":"ref16","doi-asserted-by":"publisher","first-page":"1959","DOI":"10.1245\/s10434-008-9884-3","article-title":"Tumor diameter as a prognostic factor in patients with gastric cancer","volume":"15","author":"Kunisaki C","year":"2008","journal-title":"Ann Surg Oncol"},{"issue":"12","key":"ref17","doi-asserted-by":"publisher","first-page":"1576","DOI":"10.1002\/bjs.9640","article-title":"Impact of extranodal extension on prognosis in lymph node-positive gastric cancer","volume":"101","author":"Lee IS","year":"2014","journal-title":"Br J Surg"},{"issue":"10","key":"ref18","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1056\/NEJMoa010187","article-title":"Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction","volume":"345","author":"Macdonald JS","year":"2001","journal-title":"N Engl J Med"},{"issue":"1","key":"ref19","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.amjsurg.2010.12.007","article-title":"Surgical outcomes and survival after extended multiorgan resection for T4 gastric cancer","volume":"203","author":"Mita K","year":"2012","journal-title":"Am J Surg"},{"issue":"5","key":"ref20","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/0960-7404(92)90034-I","article-title":"Risk factors which predict pattern of recurrence after curative surgery for patients with advanced gastric cancer","volume":"1","author":"Moriguchi S","year":"1992","journal-title":"Surg Oncol"},{"issue":"6","key":"ref21","doi-asserted-by":"publisher","first-page":"478","DOI":"10.5946\/ce.2014.47.6.478","article-title":"Prevention strategies for gastric cancer a global perspective","volume":"47","author":"Park JY","year":"2014","journal-title":"Clin Endosc"},{"key":"ref22","series-title":"Statistics for Windows, Version 18.0","year":"2007"},{"issue":"7","key":"ref23","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1007\/s10434-000-0520-0","article-title":"Proximal versus distal gastric carcinoma - what are the differences","volume":"7","author":"Piso P","year":"2000","journal-title":"Ann Surg Oncol"},{"issue":"1","key":"ref24","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1590\/S0102-67202015000100017","article-title":"Comparison of laparoscopic total gastrectomy and laparotomic total gastrectomy for gastric cancer","volume":"28","author":"Ramagem CAG","year":"2015","journal-title":"ABCD, arq. bras. cir. dig."},{"issue":"2","key":"ref25","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1046\/j.1365-2168.1998.00558.x","article-title":"Prognostic factors in a series of 297 patients with gastric adenocarcinoma undergoing surgical resection","volume":"85","author":"Sanchez-Bueno F","year":"1998","journal-title":"Br J Surg"},{"issue":"5","key":"ref26","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1001\/archsurg.1996.01430170027003","article-title":"Surgical aspects of patients with adenocarcinoma of the stomach operated on for cure","volume":"131","author":"Soreide JA","year":"1996","journal-title":"Arch Surg"},{"issue":"4","key":"ref27","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1016\/S0039-6060(03)00337-4","article-title":"Surgical outcomes of patients with gastric carcinoma the importance of primary tumor location and microvessel invasion","volume":"134","author":"Talamonti MS","year":"2003","journal-title":"Surgery"},{"issue":"9","key":"ref28","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1016\/S1470-2045(07)70246-2","article-title":"Recent cancer survival in Europe a 2000-02 period analysis of EUROCARE-4 data","volume":"8","author":"Verdecchia A","year":"2007","journal-title":"Lancet Oncol"},{"issue":"3","key":"ref29","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1590\/S0102-67202012000300005","article-title":"Resultados da gastrectomia D2 para o c\u00e2ncer g\u00e1strico: dissec\u00e7\u00e3o da cadeia linf\u00e1tica ou ressec\u00e7\u00e3o linfonodal m\u00faltipla?","volume":"25","author":"Zilberstein Bruno","year":"2012","journal-title":"ABCD, arq. bras. cir. dig"},{"issue":"1","key":"ref30","article-title":"Stage-stratified analysis of prognostic significance of tumor size in patients with gastric cancer","volume":"8","author":"Zu H","year":"2013","journal-title":"PLoS One"}],"container-title":["ABCD. Arquivos Brasileiros de Cirurgia Digestiva (S\u00e3o Paulo)"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/abcd\/v29n4\/0102-6720-abcd-29-04-00232.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,4,28]],"date-time":"2017-04-28T16:25:14Z","timestamp":1493396714000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0102-67202016000400232&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["S0102-67202016000400232"],"URL":"https:\/\/doi.org\/10.1590\/0102-6720201600040005","relation":{},"ISSN":["0102-6720"],"issn-type":[{"value":"0102-6720","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12]]}}}