{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T06:41:56Z","timestamp":1722840116826},"reference-count":20,"publisher":"FapUNIFESP (SciELO)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ABCD, arq. bras. cir. dig."],"abstract":"<jats:p>ABSTRACT Background: The role of autonomic nervous system in the development and maintenance of portal hypertension is not fully elucidated. It is known that the gene expression of norepinephrine in the superior mesenteric artery varies with time, and it may contribute for splanchnic vasodilation and its consequent hemodynamic repercussions. It is still not known exactly how the adrenergic expression behaves at the heart level in the initial stages of this process. Aim: To evaluate the immunohistochemical expression of the enzyme tyrosine hydroxylase (tyrosine 3-monooxygenase), involved in the synthesis of norepinephrine, in the myocardium of rats submitted to partial ligation of the portal vein. Methods: Twenty-four Wistar rats were divided into two groups: Sham Operated and Portal Hypertension. The partial ligation was performed in the Portal Hypertension group, and after 1\/6\/24 h and 3\/5\/14 days the animals were euthanized. Immunohistochemical analysis was performed to quantify the expression of the stained enzyme using the ImageJ program. Results: The Portal Hypertension group expressed percentages between 4.6-6% of the marked area, while the Sham Operated group varied between 4-5%. Although there was no statistical significance, the percentage stained in the Portal Hypertension group followed an increasing pattern in the first 6 h and a decreasing pattern after 24 h, which was not observed in the Sham Operated group. Conclusion: The expression of noradrenaline in rat myocardium during the first two weeks after partial ligation of the portal vein, with tyrosine hydroxylase as marker, did not show differences between groups over time.<\/jats:p>","DOI":"10.1590\/0102-672020180001e1383","type":"journal-article","created":{"date-parts":[[2018,8,15]],"date-time":"2018-08-15T19:49:40Z","timestamp":1534362580000},"source":"Crossref","is-referenced-by-count":2,"title":["INVOLVEMENT OF CATECHOLAMINES IN THE MYOCARDIUM OF RATS SUBMITTED TO EXPERIMENTAL MODEL OF PORTAL HYPERTENSION"],"prefix":"10.1590","volume":"31","author":[{"given":"Antonella","family":"VINHOLI","sequence":"first","affiliation":[{"name":"Faculdade Evang\u00e9lica do Paran\u00e1, Brazil; Denton Cooley Institute, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00edlia Da Cruz","family":"FAGUNDES","sequence":"additional","affiliation":[{"name":"Faculdade Evang\u00e9lica do Paran\u00e1, Brazil; Denton Cooley Institute, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danieli Cristina","family":"PIGOZZO","sequence":"additional","affiliation":[{"name":"Faculdade Evang\u00e9lica do Paran\u00e1, Brazil; Denton Cooley Institute, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando Bermudez","family":"KUBRUSLY","sequence":"additional","affiliation":[{"name":"Denton Cooley Institute, USA; Universidade Federal do Paran\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz Fernando","family":"KUBRUSLY","sequence":"additional","affiliation":[{"name":"Faculdade Evang\u00e9lica do Paran\u00e1, Brazil; Denton Cooley Institute, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camila Aparecida Moraes","family":"MARQUES","sequence":"additional","affiliation":[{"name":"Universidade Federal do Paran\u00e1, Brazil; Denton Cooley Institute, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2018,8,16]]},"reference":[{"issue":"41","key":"ref1","doi-asserted-by":"crossref","first-page":"6577","DOI":"10.3748\/wjg.v12.i41.6577","article-title":"G, Pasarin M, Garc\u00eda-Pag\u00e1n JC Animal models of portal hypertension","volume":"12","author":"Abraldes J","year":"2006","journal-title":"World J Gastroenterol"},{"issue":"4","key":"ref2","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0168-8278(85)80770-4","article-title":"Reduction of the increased portal vascular resistance of the isolated perfused cirrhotic rat liver by vasodilators","volume":"1","author":"Bhathal PS","year":"1985","journal-title":"J Hepatol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/S0168-8278(02)00430-0","article-title":"Current management of portal hypertension","volume":"38","author":"Bosch J","year":"2003","journal-title":"J 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