{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:04:07Z","timestamp":1753887847435,"version":"3.41.2"},"reference-count":24,"publisher":"FapUNIFESP (SciELO)","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ABCD, arq. bras. cir. dig."],"abstract":"<jats:p>ABSTRACT  Background: Hepatectomies promote considerable amount of blood loss and the need to administrate blood products, which are directly linked to higher morbimortality rates. The blood-conserving hepatectomy (BCH) is a modification of the selective vascular occlusion technique. It could be a surgical maneuver in order to avoid or to reduce the blood products utilization in the perioperative period.  Aim: To evaluate in rats the BCH effects on the hematocrit (HT) variation, hemoglobin serum concentration (HB), and on liver regeneration.  Methods: Twelve Wistar rats were divided into two groups: control (n=6) and intervention (n=6). The ones in the control group had their livers partially removed according to the Higgins and Anderson technique, while the rats in the treatment group were submitted to BCH technique. HT and HB levels were measured at day D0, D1 and D7. The rate between the liver and rat weights was calculated in D0 and D7. Liver regeneration was quantitatively and qualitatively evaluated.  Results: The HT and HB levels were lower in the control group as of D1 onwards, reaching an 18% gap at D7 (p=0.01 and p=0.008, respectively); BCH resulted in the preservation of HT and HB levels to the intervention group rats. BCH did not alter liver regeneration in rats.  Conclusion: The BCH led to beneficial effects over the postoperative HT and serum HB levels with no setbacks to liver regeneration. These data are the necessary proof of evidence for translational research into the surgical practice.<\/jats:p>","DOI":"10.1590\/0102-672020190001e1","type":"journal-article","created":{"date-parts":[[2020,3,31]],"date-time":"2020-03-31T12:04:43Z","timestamp":1585656283000},"source":"Crossref","is-referenced-by-count":1,"title":["Conservation of both hematocrit and liver regeneration in hepatectomies: a vascular occlusion approach in rats"],"prefix":"10.1590","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3648-8605","authenticated-orcid":false,"given":"Eduardo Augustus","family":"MALINOWSKI","sequence":"first","affiliation":[{"name":"Federal University of Paran\u00e1,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6377-8870","authenticated-orcid":false,"given":"Jorge Eduardo Fouto","family":"MATIAS","sequence":"additional","affiliation":[{"name":"Federal University of Paran\u00e1,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6325-0195","authenticated-orcid":false,"given":"Ana Paula","family":"PERCICOTE","sequence":"additional","affiliation":[{"name":"Federal University of Paran\u00e1,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tha\u00edsa","family":"NAKADOMARI","sequence":"additional","affiliation":[{"name":"Federal University of Paran\u00e1,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3598-6370","authenticated-orcid":false,"given":"Rog\u00e9rio","family":"ROBES","sequence":"additional","affiliation":[{"name":"Federal University of Paran\u00e1,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7735-1077","authenticated-orcid":false,"given":"Ricardo Rasmussen","family":"PETTERLE","sequence":"additional","affiliation":[{"name":"Federal University of Paran\u00e1,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0310-7164","authenticated-orcid":false,"given":"L\u00facia De","family":"NORONHA","sequence":"additional","affiliation":[{"name":"Federal University of Paran\u00e1,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6703-9546","authenticated-orcid":false,"given":"Jose Luiz De","family":"GODOY","sequence":"additional","affiliation":[{"name":"Federal University of Paran\u00e1,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2020]]},"reference":[{"issue":"4","key":"ref1","first-page":"766","article-title":"Ottawa Criteria for Appropriate Transfusions in Hepatectomy Using the RAND\/UCLA Appropriateness Method.[Article]. Annals of","volume":"267","author":"Bennett SM","year":"2018","journal-title":"Surgery"},{"issue":"1","key":"ref2","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1097\/00000658-198907000-00002","article-title":"Major hepatic resection under total vascular exclusion","volume":"210","author":"Bismuth H","year":"1989","journal-title":"Annals of Surgery"},{"issue":"19","key":"ref3","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1001\/jama.2016.9185","article-title":"Clinical Practice Guidelines From the AABB Red Blood Cell Transfusion Thresholds and Storage","volume":"316","author":"Carson JL","year":"2016","journal-title":"Jama"},{"issue":"41","key":"ref4","first-page":"1416","article-title":"Comparison of continuous versus intermittent hepatic pedicle clamping in an experimental model","volume":"48","author":"Chiappa A","year":"2001","journal-title":"Hepato-Gastroenterology"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.1477-2574.2009.00126.x","article-title":"Predictors of blood transfusion requirement in elective liver resection","volume":"12","author":"Cockbain AJ","year":"2010","journal-title":"Hpb"},{"issue":"10","key":"ref6","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1096\/fasebj.10.10.8751714","article-title":"Liverregeneration 8. Liver regeneration versus direct hyperplasia","volume":"10","author":"Columbano A","year":"1996","journal-title":"FasebJournal"},{"issue":"3","key":"ref7","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1002\/hep.510270310","article-title":"Hepatic regeneration in the isolated perfused rat liver followed by liver transplantation","volume":"27","author":"De Godoy JL","year":"1998","journal-title":"Hepatology"},{"issue":"4","key":"ref8","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1067\/msy.1998.91225","article-title":"Liver resection using total vascular exclusion","volume":"124","author":"Evans PM","year":"1998","journal-title":"Surgery"},{"issue":"1","key":"ref9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4254\/wjh.v5.i1.1","article-title":"Blood loss, predictors of bleeding, transfusion practice and strategies of blood cell salvaging during liver transplantation","volume":"5","author":"Feltracco P","year":"2013","journal-title":"World Journal of Hepatology"},{"issue":"4","key":"ref10","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1097\/01.sla.0000157168.26021.b8","article-title":"Complete versus selective portal triad clamping for minor liver resections a prospective randomized trial","volume":"241","author":"Figueras J","year":"2005","journal-title":"Ann Surg"},{"issue":"1","key":"ref11","article-title":"Liver resection in Brazil a national survey","volume":"31","author":"Fonseca GM","year":"2018","journal-title":"ArqBrasCirDig"},{"issue":"1","key":"ref12","article-title":"Percutaneousradiofrequencyassistedliverpartitionwith portal veinembolization for stagedhepatectomy (PRALPPS)","volume":"31","author":"Gim\u00e9nez ME","year":"2018","journal-title":"ArqBrasCirDig"},{"issue":"9880","key":"ref13","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1016\/S0140-6736(13)60673-X","article-title":"Blood management: transfusion medicine comes of age","volume":"381","author":"Goodnough LT","journal-title":"The Lancet"},{"issue":"7","key":"ref14","first-page":"842","article-title":"A Morphologic Study of Deoxyribonucleic Acid Synthesis and Cell Proliferation in Regenerating Rat Liver; Autoradiography with Thymidine-H3","volume":"22","author":"Grisham JW","year":"1962","journal-title":"Cancer Research"},{"key":"ref15","first-page":"Cd007632","article-title":"Methods of vascular occlusion for elective liver resections","volume":"1","author":"Gurusamy KS","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"issue":"2","key":"ref16","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.ejso.2014.10.057","article-title":"A prospective randomized controlled trial comparison of two different methods of hepatectomy","volume":"41","author":"Hanyong S","year":"2015","journal-title":"Eur J SurgOncol"},{"key":"ref17","first-page":"186","article-title":"Arch Experimental pathology of the liver. I. Restoration of the liver of the white rat following partial surgical removal","volume":"12","author":"Higgins GM","year":"1931","journal-title":"Arch Pathol"},{"issue":"1","key":"ref18","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1159\/000335724","article-title":"Vascular Occlusion or Not during Liver Resection The Continuing Story","volume":"29","author":"Hoekstra LT","year":"2012","journal-title":"Digestive Surgery"},{"issue":"4","key":"ref19","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1097\/00000658-200210000-00001","article-title":"Improvement in Perioperative Outcome After Hepatic Resection Analysis of 1,803 Consecutive Cases Over the Past Decade","volume":"236","author":"Jarnagin WR","year":"2002","journal-title":"Annals of Surgery"},{"issue":"4","key":"ref20","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1002\/bjs.10416","article-title":"Three-point transfusion risk score in hepatectomy","volume":"104","author":"Lemke M","year":"2017","journal-title":"British Journal of Surgery"},{"issue":"7","key":"ref21","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1002\/bjs.5731","article-title":"A risk score for predicting perioperative blood transfusion in liver surgery","volume":"94","author":"Pulitano C","year":"2007","journal-title":"British Journal of Surgery"},{"issue":"4","key":"ref22","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1111\/j.1537-2995.2009.02518.x","article-title":"Activity-based costs of blood transfusions in surgical patients at four hospitals","volume":"50","author":"Shander A","year":"2010","journal-title":"Transfusion"},{"issue":"6","key":"ref23","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1097\/SLA.0b013e3181b7fad3","article-title":"Predicting the Risk of Perioperative Transfusion for Patients Undergoing Elective Hepatectomy","volume":"250","author":"Sima CS","year":"2009","journal-title":"Annals of Surgery"},{"issue":"5","key":"ref24","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1111\/trf.12958","article-title":"Increased hospital costs associated with red blood cell transfusion","volume":"55","author":"Trentino KM","year":"2015","journal-title":"Transfusion"}],"container-title":["ABCD. Arquivos Brasileiros de Cirurgia Digestiva (S\u00e3o Paulo)"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/abcd\/v33n1\/0102-6720-abcd-33-01-e1484.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,23]],"date-time":"2021-01-23T14:51:31Z","timestamp":1611413491000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0102-67202020000100301&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":24,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020]]}},"alternative-id":["S0102-67202020000100301"],"URL":"https:\/\/doi.org\/10.1590\/0102-672020190001e1","relation":{},"ISSN":["2317-6326","0102-6720"],"issn-type":[{"type":"electronic","value":"2317-6326"},{"type":"print","value":"0102-6720"}],"subject":[],"published":{"date-parts":[[2020]]},"article-number":"e1484"}}