{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T07:22:24Z","timestamp":1793949744165,"version":"4.8.0"},"reference-count":43,"publisher":"FapUNIFESP (SciELO)","issue":"3","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ABCD, arq. bras. cir. dig."],"abstract":"<jats:p>ABSTRACT  Introduction: Many published studies have estimated the association of rs2435357 and rs1800858 polymorphisms in the proto-oncogene rearranged during transfection (RET) gene with Hirschsprung disease (HSCR) risk. However, the results remain inconsistent and controversial.  Aim: To perform a meta-analysis get a more accurate estimation of the association of rs2435357 and rs1800858 polymorphisms in the RET proto-oncogene with HSCR risk.  Methods: The eligible literatures were searched by PubMed, Google Scholar, EMBASE, and Chinese National Knowledge Infrastructure (CNKI) up to June 30, 2018. Summary odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the susceptibility to HSCR.  Results: A total of 20 studies, including ten (1,136 cases 2,420 controls) for rs2435357 and ten (917 cases 1,159 controls) for rs1800858 were included. The overall results indicated that the rs2435357 (allele model: OR=0.230, 95% CI 0.178-0.298, p=0.001; homozygote model: OR=0.079, 95% CI 0.048-0.130, p=0.001; heterozygote model: OR=0.149, 95% CI 0.048-0.130, p=0.001; dominant model: OR=0.132, 95% CI 0.098-0.179, p=0.001; and recessive model: OR=0.239, 95% CI 0.161-0.353, p=0.001) and rs1800858 (allele model: OR=5.594, 95% CI 3.653-8.877, p=0.001; homozygote model: OR=8.453, 95% CI 3.783-18.890, p=0.001; dominant model: OR=3.469, 95% CI 1.881-6.396, p=0.001; and recessive model: OR=6.120, 95% CI 3.608-10.381, p=0.001) polymorphisms were associated with the increased risk of HSCR in overall.  Conclusions: The results suggest that the rs2435357 and rs1800858 polymorphisms in the RET proto-oncogene might be associated with HSCR risk.<\/jats:p>","DOI":"10.1590\/0102-672020190001e1448","type":"journal-article","created":{"date-parts":[[2019,10,19]],"date-time":"2019-10-19T15:41:04Z","timestamp":1571499664000},"source":"Crossref","is-referenced-by-count":7,"title":["ASSOCIATION OF RS2435357 AND RS1800858 POLYMORPHISMS IN RET PROTO-ONCOGENE WITH HIRSCHSPRUNG DISEASE: SYSTEMATIC REVIEW AND META-ANALYSIS"],"prefix":"10.1590","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0864-341X","authenticated-orcid":false,"given":"Abdolhamid","family":"AMOOEE","sequence":"first","affiliation":[{"name":"Shahid Sadoughi University of Medical Sciences,  Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad Hosein","family":"LOOKZADEH","sequence":"additional","affiliation":[{"name":"Shahid Sadoughi University of Medical Sciences,  Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Reza","family":"MIRJALILI","sequence":"additional","affiliation":[{"name":"Shahid Sadoughi University of Medical Sciences,  Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Mohsen","family":"MIRESMAEILI","sequence":"additional","affiliation":[{"name":"Science and Art University,  Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazem","family":"AGHILI","sequence":"additional","affiliation":[{"name":"Shahid Sadoughi University of Medical Sciences,  Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masoud","family":"ZARE-SHEHNEH","sequence":"additional","affiliation":[{"name":"Shahid Sadoughi University of Medical Sciences,  Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"NEAMATZADEH","sequence":"additional","affiliation":[{"name":"Shahid Sadoughi University of Medical Sciences,  Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2019]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/jmg.2007.053959","article-title":"Hirschsprung disease, associated syndromes and genetics a review","volume":"45","author":"Amiel J","year":"2007","journal-title":"Journal of Medical Genetics"},{"issue":"4","key":"ref2","article-title":"Association of Tumor Necrosis Factor-a (TNF-a) -308G>A and -238G>A Polymorphisms with Recurrent Pregnancy Loss Risk: A Meta-Analysis","author":"Aslebahar F","year":"2019","journal-title":"International Journal of Fertility & Sterility"},{"issue":"5","key":"ref3","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1002\/humu.20944","article-title":"Interaction between a chromosome 10 RET enhancer and chromosome 21 in the Down syndrome-Hirschsprung disease association","volume":"30","author":"Arnold 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