{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T11:20:44Z","timestamp":1764588044724,"version":"3.41.2"},"reference-count":32,"publisher":"FapUNIFESP (SciELO)","issue":"4","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ABCD, arq. bras. cir. dig."],"abstract":"<jats:p>ABSTRACT  Background: Crohn\u2019s disease is a pathological condition that has different options of treatment, but there are patients who need other therapeutic approach, such as the use of adipose-derived mesenchymal stem cells.  Aim: Systematic literature review to determine the different ways of adipose-derived mesenchymal stem cells administration in humans with luminal refractory and perianal fistulizing Crohn\u2019s disease.  Methods: It was conducted a search for articles (from 2008 to 2018) on PubMed and ScienceDirect databases using the keywords Crohn\u2019s disease, fistulizing Crohn\u2019s disease, luminal Crohn\u2019s disease and transplantation of mesenchymal stem cells or mesenchymal stem cells or stromal cells. Thirteen publications were selected for analysis.  Results: Only one study referred to the luminal Crohn\u00b4s disease. The number of cells administered was variable, occurring mainly through subcutaneous adipose tissue by liposuction. It could be highlighted the autologous transplant with exclusive infusion of mesenchymal stem cells. The procedures involved in pre-transplant were mainly curettage, setons placement and stitching with absorbable suture, and conducting tests and drug treatment for luminal Crohn\u00b4s disease. During transplant, the injection of mesenchymal stem cells across the fistula path during the transplant was mainly on the intestinal tract wall.  Conclusion: Although the use of mesenchymal stem cells is promising, the transplant on the luminal region should be more investigated. The injection of mesenchymal stem cells, exclusively, is more explored when compared to treatment with other products. The preparation of the fistulizing tract and the location of cell transplantation involve standardized health care in most studies.<\/jats:p>","DOI":"10.1590\/0102-672020190001e1465","type":"journal-article","created":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T12:58:07Z","timestamp":1576846687000},"source":"Crossref","is-referenced-by-count":13,"title":["TRANSPLANTATION OF ADIPOSE-DERIVED MESENCHYMAL STEM CELLS IN REFRACTORY CROHN\u2019S DISEASE: SYSTEMATIC REVIEW"],"prefix":"10.1590","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8650-3105","authenticated-orcid":false,"given":"Luana","family":"BERNARDI","sequence":"first","affiliation":[{"name":"Faculty of Medicine,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5226-0355","authenticated-orcid":false,"given":"Carlos Henrique Marques dos","family":"SANTOS","sequence":"additional","affiliation":[{"name":"Federal University of Mato Grosso do Sul,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8898-4216","authenticated-orcid":false,"given":"Ver\u00f4nica Assalin Zorgetto","family":"PINHEIRO","sequence":"additional","affiliation":[{"name":"Faculty of Medicine,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3514-3346","authenticated-orcid":false,"given":"Rodrigo Juliano","family":"OLIVEIRA","sequence":"additional","affiliation":[{"name":"Faculty of Medicine,  Brazil; Maria Aparecida Pedrossian University Hospital,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2525-7019","authenticated-orcid":false,"given":"Andreia Concei\u00e7\u00e3o Milan Brochado","family":"ANTONIOLLI-SILVA","sequence":"additional","affiliation":[{"name":"Faculty of Medicine,  Brazil; Maria Aparecida Pedrossian University Hospital,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2019]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1016\/S0140-6736(12)60026-9","article-title":"Crohn&apos;s disease","volume":"380","author":"Baumgart DC","year":"2012","journal-title":"Lancet"},{"issue":"2","key":"ref2","first-page":"1","article-title":"The Incidence and Prevalence of Crohn&apos;s Disease in Global Scale","volume":"3","author":"Behzadi P","year":"2015","journal-title":"SOJ Immunol"},{"issue":"7","key":"ref3","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1080\/14712598.2018.1492543","article-title":"Human mesenchymal stem cell therapy in the management of luminal and perianal fistulizing Crohn&apos;s disease - review of pathomechanism and existing clinical data","volume":"18","author":"Bor R","year":"2018","journal-title":"Expert Opin Biol 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Arquivos Brasileiros de Cirurgia Digestiva (S\u00e3o Paulo)"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/abcd\/v32n4\/0102-6720-abcd-32-04-e1465.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T23:37:06Z","timestamp":1596238626000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0102-67202019000400500&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":32,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019]]}},"alternative-id":["S0102-67202019000400500"],"URL":"https:\/\/doi.org\/10.1590\/0102-672020190001e1465","relation":{},"ISSN":["2317-6326","0102-6720"],"issn-type":[{"type":"electronic","value":"2317-6326"},{"type":"print","value":"0102-6720"}],"subject":[],"published":{"date-parts":[[2019]]},"article-number":"e1465"}}